Nephrology

Latest AI and machine learning research in nephrology for healthcare professionals.

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Sleep Duration and Diabetic Kidney Disease.

Abnormally short or long durations of sleep have been proposed as a risk factors for diabetes and its micro- and macro-vascular complications. However, the relationship between sleep duration and diabetic kidney disease (DKD) has not been well-characterized. Thus, we aimed to examine the association of sleep duration with DKD in two Asian populations. We included 1,258 persons (Malay, = 403; In...

Jan 14 2019 30692966

Using machine learning and an ensemble of methods to predict kidney transplant survival.

We used an ensemble of statistical methods to build a model that predicts kidney transplant survival and identifies important predictive variables. The proposed model achieved better performance, measured by Harrell's concordance index, than the Estimated Post Transplant Survival model used in the kidney allocation system in the U.S., and other models published recently in the literature. The mode...

Jan 9 2019 30625130
A Large Animal Model of Right Ventricular Failure due to Chronic Thromboembolic Pulmonary Hypertension: A Focus on Function.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a debilitating disease that progresses to right ventricular (RV) failure and death if left un...

Jan 9 2019 30687717
A clinical, proteomics, and artificial intelligence-driven model to predict acute kidney injury in patients undergoing coronary angiography.

BACKGROUND: Standard measures of kidney function are only modestly useful for accurate prediction of risk for acute kidney injury (AKI).

Jan 8 2019 30582197
Radiogenomics in Clear Cell Renal Cell Carcinoma: Machine Learning-Based High-Dimensional Quantitative CT Texture Analysis in Predicting PBRM1 Mutation Status.

OBJECTIVE: The purpose of this study is to evaluate the potential value of machine learning (ML)-based high-dimensional quantitative CT texture analys...

Jan 2 2019 30601030
Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma.

Searching for new leads in the battle of cancer will never ends, we herein disclose the design and synthesis of new phthalazine derivatives and their ...

Dec 31 2018 30654221
Adult Idiopathic Renal Fanconi Syndrome: A Case Report.

Renal Fanconi syndrome (RFS) is caused by generalized proximal tubular dysfunction and can be divided into hereditary and acquired form. Adult-onset R...

Dec 31 2018 30899310
Renal Function Impairment in Kidney Transplantation: Importance of Early BK Virus Detection.

BACKGROUND: BK virus allograft nephropathy is a major complication of kidney transplantation that markedly reduces graft survival (50% graft failure 2...

Dec 30 2018 30879539
Neutrophil gelatinase-associated lipocalin: An early biomarker for predicting acute kidney injury and severity in patients with acute pancreatitis.

BACKGROUND AND AIM: Acute kidney injury (AKI) in severe acute pancreatitis (SAP) has a high mortality rate. Traditionally used serum creatinine is an ...

Dec 27 2018 31061884
Treatment With Grazoprevir/Elbasvir for Renal Transplant Recipients With Chronic Hepatitis C Virus Infection and Impaired Allograft Function.

BACKGROUND: Direct-acing antiviral agents are highly efficient treatment options for chronic hepatitis C virus (HCV) infection after renal allograft t...

Dec 27 2018 30656217
The Role of GDF-15 in Heart Failure Patients With Chronic Kidney Disease.

BACKGROUND: Growth differentiation factor-15 (GDF-15) is a stress-inducible cytokine and member of the transforming growth factor-β cytokine superfami...

Dec 26 2018 30935637
Ceftaroline Fosamil as an Alternative for a Severe Methicillin-resistant Staphylococcus aureus Infection: A Case Report.

Bacteremia secondary to methicillin-resistant Staphylococcus aureus (MRSA) is a dreaded medical condition that is not only associated with a significa...

Dec 25 2018 30820395
Early Versus Late Conversion From Immediate to Prolonged-Release Tacrolimus After Renal Transplantation: Clinical Effects and Treatment Costs.

INTRODUCTION: Prolonged-release tacrolimus (PR-TAC) was associated with improved renal function after transplantation when compared to immediate-relea...

Dec 20 2018 30656215
Capillary electrophoresis with preparative isoelectric focusing preconcentration for sensitive determination of amphotericin B in human blood serum.

Amphotericin B (AmB) is still, despite its severe nephrotoxicity, the first-line agent in the management of serious systemic fungal infections. A sens...

Dec 18 2018 30712562
MYH9-related disorders display heterogeneous kidney involvement and outcome.

BACKGROUND: MYH9-related diseases (MYH9-RD) are autosomal dominant disorders caused by mutations of the gene encoding the non-muscle myosin heavy cha...

Dec 17 2018 31384440
Colorimetric sensing of palladium ions based on in situ generation of palladium nanoparticles as an activator for the thionine-hydrazine reaction.

In this article, a simple and rapid colorimetric sensing method was developed for the determination of palladium ions. The method is based on in situ ...

Dec 17 2018 30683353
Age-Dependent Progression of Renal Dysfunction After Adrenalectomy for Aldosterone-Producing Adenomas in Japan.

CONTEXT: In patients with aldosterone-producing adenomas (APAs), adrenalectomy causes a rapid decrease in blood pressure and increase in blood potassi...

Dec 17 2018 30805569
Factors involved in phenoconversion of CYP3A using 4β-hydroxycholesterol in stable kidney transplant recipients.

BACKGROUND: Phenoconversion is a phenomenon whereby some genotypic extensive metabolizers transiently exhibit drug metabolizing enzyme activity at sim...

Dec 15 2018 30826567
Prediction of Hemodialysis Timing Based on LVW Feature Selection and Ensemble Learning.

We propose an improved model based on LVW embedded model feature extractor and ensemble learning for improving prediction accuracy of hemodialysis tim...

Dec 13 2018 30547238
ShenShuai II Recipe Attenuates Apoptosis and Renal Fibrosis in Chronic Kidney Disease by Increasing Renal Blood Flow and Improving Oxygen Consumption.

. Hypoxia plays a significant role in the progression of chronic kidney disease (CKD) and renal fibrosis. In China, Chinese herbal medicine has been w...

Dec 13 2018 30643536
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