Nephrology

Latest AI and machine learning research in nephrology for healthcare professionals.

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Morphometric analysis and its application in lupus nephritis: a systematic review.

Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE), characterized by marked histological heterogeneity and high interobserver variability in the evaluation of renal biopsies. Digital morphometry has emerged as an objective and reproducible tool that enables precise quantification of tissuelesions, thereby enhancing diagnostic accuracy and prognostic assessment. To...

Jan 19 2026 41553994

OLink proteomic biomarker to predict clinical efficacy of Macaranga sinensis Müll.Arg: A nested case-control study.

ETHNOPHARMACOLOGICAL RELEVANCE: Despite the fact that herbal medicine has been used for a long time, their clinical application is challenged by unclear active ingredients and poorly understood mechanisms of action, resulting in considerable heterogeneity in therapeutic outcomes among patients. AIM OF THE STUDY: To explore the use of OLink-based biomarkers to predict the efficacy of Macaranga sine...

Jan 18 2026 41558579
Machine learning and SHAP values for predicting coronary artery disease risk in Xinjiang, China.

BACKGROUND: Accurate individual risk assessment is crucial for guiding and improving the prevention of atherosclerotic cardiovascular disease (ASCVD)....

Jan 17 2026 41545835
Gene Modification: Exploring the potential in treating kidney diseases.

Chronic kidney disease (CKD) is a leading cause of death worldwide. Currently available drugs slow but do not cure or prevent progression to end-stage...

Jan 17 2026 41554351
Using Latent Dirichlet Allocation Topic Modeling to Uncover Latent Research Topics and Trends in Renal Cell Carcinoma: Bibliometric Review.

BACKGROUND: Renal cell carcinoma (RCC) is a common, often lethal kidney cancer that originates in the renal cortex. Its incidence is rising, and major...

Jan 16 2026 41544251
AI-assisted multimodal assessment for right ventricular function from echocardiography predicts mortality in patients with pulmonary hypertension and right heart failure.

Right ventricular (RV) strain is an important factor in evaluating RV function. This study aimed to predict mortality in patients with pulmonary hyper...

Jan 16 2026 41545551
A Deep Learning Model for Dynamic Prediction of Acute Kidney Injury in Heart Failure Patientss.

BACKGROUND: This study aimed to develop and validate a dynamic prediction model for acute kidney injury (AKI) in heart failure (HF) patients. METHODS:...

Jan 16 2026 41548653
Development of a Patient-Specific Fontan Failure Risk Calculator Using Machine Learning - A Step Towards Personalized Medicine.

OBJECTIVE: The Fontan operation is the final step in staged palliation for patients with single ventricle physiology. It has extended their life expec...

Jan 16 2026 41548840
LGDUnet: A dual-branch network for weakly supervised gland segmentation in H&E stained histopathological images.

Glandular segmentation holds significant importance in the pathological analysis of hematoxylin and eosin (H&E) stained images, particularly in the di...

Jan 16 2026 41549958
[Toe-to-hand transplantation for thumb and finger reconstruction].

Reconstruction of missing thumbs or fingers remains one of the most demanding challenges in hand surgery. Over the past century, toe-to-hand transplan...

Jan 15 2026 41539703
Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches.

BACKGROUND: Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is ste...

Jan 15 2026 41540661
Medicinal chemistry meets nanotechnology: machine learning assisted colorimetric sensing platform for oxalic acid based on drug mediated copper oxide nanoparticles.

Increased levels of oxalic acid are associated with an increased risk of kidney stone formation, which can lead to renal failure. In addition, its hig...

Jan 15 2026 41550798
Peak strain dispersion as a nonlinear mediator in HFpEF: Unraveling subtype-specific pathways via SHAP-augmented ensemble modeling.

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) represents a heterogeneous syndrome with diverse pathophysiological mechanisms and ...

Jan 14 2026 41533691
Old Criteria, New Intelligence: The Evolution of ECG in Pulmonary Hypertension Diagnosis.

BACKGROUND: Pulmonary hypertension (PH) carries a significant mortality risk, highlighting the need for improved early detection strategies. This revi...

Jan 14 2026 41544985
Assessment of Correlation Between Diabetic Retinopathy and Metabolic Biomarkers Using Artificial Intelligence.

BACKGROUND: One of the main causes of blindness in the world, diabetic retinopathy (DR) is a dangerous condition that impairs vision in diabetics. Pre...

Jan 14 2026 41541002
Mechanism-informed machine learning for individualized tacrolimus dose adjustment in the early post-kidney transplant period.

AIM: Tacrolimus dosing in the early post-kidney transplant period is challenging due to a narrow therapeutic index and substantial interindividual pha...

Jan 13 2026 41531243
A nomogram model for challenging cases: differentiating fat-poor angiomyolipoma from clear cell renal cell carcinoma in uncertain or misdiagnosed tumors.

PURPOSE: To develop and validate a nomogram model that can accurately differentiate fat-poor angiomyolipoma (fp-AML) from clear cell renal cell carcin...

Jan 12 2026 41524985
Predicting cardiovascular diseases using imbalanced data: An XGBoost-based analysis of the 2022 BRFSS dataset.

BACKGROUND: Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, arising from complex interactions among demographic, clini...

Jan 10 2026 41631000
Beyond the Cell Atlas: Functional Communities as the Essential Pathologic Units Driving Kidney Disease.

Kidney disease represents a growing global health crisis, demanding a deeper understanding of its underlying pathophysiology. Current mechanistic effo...

Jan 9 2026 41563353
Impact of continuing renin-angiotensin-aldosterone system inhibitors before surgery on intraoperative hypotensive events: a secondary analysis of the STOP-or-NOT Trial.

BACKGROUND: The multicentre STOP-or-NOT trial has shown that continuation of renin-angiotensin-aldosterone inhibitors (RAASis) before major noncardiac...

Jan 9 2026 41513520
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