Neurology

Latest AI and machine learning research in neurology for healthcare professionals.

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Is it possible to vaccinate AI against bias? An exploratory study in epilepsy

Large language models are increasingly used for clinical decision support yet may perpetuate socioeconomic biases. Whether simple prompt-based interventions can mitigate such biases remains unknown. To determine whether a prompt-based ‘inoculation’ instructing large-language-models (LLMs) to disregard clinically irrelevant information can reduce bias and improve accuracy in recommendations. Experi...

Surface EEG to identify cognitive motor dissociation after acute brain injury

Cognitive motor dissociation (CMD) is associated with long-term recovery in acute brain injury, but CMD testing is only available in few centers. Our objective was to identify surface EEG patterns with high sensitivity or positive predictive value (PPV) for CMD in patients with acute disorders of consciousness to refine allocation of this resource-intensive test. In this observational cohort study...

Evaluation of SSI risk prediction model after spinal surgery: A systematic review and critical appraisal

This study aimed to systematically review and critically evaluate the risk of bias and applicability of surgical site infection (SSI) risk prediction ...

Data-augmented machine learning redefines the effective concentration of eculizumab in complement blood disorders

Eculizumab, a humanized monoclonal antibody targeting the complement lytic pathway protein C5, has demonstrated high efficacy in the treatment of paro...

A Comprehensive Investigation of Machine Learning Practices in Predictive Modeling of Alzheimer’s Disease and Related Dementias using Multisite Real-world Electronic Health Records

The irreversible progression and profound societal impact of Alzheimer’s disease and related dementias (AD/ADRD) underscore the pressing need for earl...

Brain Region-Centered MultiModal Hypergraph Fusion for MCI Conversion Prediction

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, with mild cognitive impairment (MCI) as its prodromal stage. Accurate MCI conver...

Dementia etiology classification using NULISA plasma biomarkers and machine learning

Accurate antemortem differentiation among dementia etiologies remains challenging, particularly for atypical or mixed clinical presentations. Multiple...

Alzheimer's disease detection based on large language model prompt engineering

In light of the growing proportion of older individuals in our society, the timely diagnosis of Alzheimer's disease has become a crucial aspect of h...

The translational power of Alzheimer's-based organoid models in personalized medicine: an integrated biological and digital approach embodying patient clinical history.

Alzheimer's disease (AD) is a complex neurodegenerative condition characterized by a multifaceted interplay of genetic, environmental, and pathologica...

Jan 1 2025 40443709
Predicting brain age for veterans with traumatic brain injuries and healthy controls: an exploratory analysis.

BACKGROUND: Traumatic brain injury (TBI) is associated with increased dementia risk. This may be driven by underlying biological changes resulting fro...

Jan 1 2025 40443792
Closing the diagnostic gap: A narrative review of recent advances in functional MRI diagnostics in spinal cord injury.

INTRODUCTION: Conventional MRI (T1 and T2-weighted sequences) is the standard for diagnosing spinal cord injuries but often lacks specificity, showing...

Jan 1 2025 40497019
The Hypothalamic Medial Preoptic Area-Paraventricular Nucleus Circuit Modulates Depressive-Like Behaviors in a Mouse Model of Postpartum Depression.

Estrogen fluctuations have been implicated in various mood disorders, including perimenopausal and postpartum depression (PPD), likely through complex...

Jan 1 2025 40370500
Knowledge map of artificial intelligence in neurodegenerative diseases: a decade-long bibliometric and visualization study.

BACKGROUND: As the incidence of neurodegenerative diseases increases, the related AI research is getting more and more advanced. In this study, we ana...

Jan 1 2025 40438502
Identification and validation of pyroptosis-related genes in Alzheimer's disease based on multi-transcriptome and machine learning.

BACKGROUND: Alzheimer's disease (AD) progression is characterized by persistent neuroinflammation, where pyroptosis-an inflammatory programmed cell de...

Jan 1 2025 40438507
Nanocarrier-based targeted drug delivery for Alzheimer's disease: addressing neuroinflammation and enhancing clinical translation.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, amyloid-beta (Aβ) aggregation, tau pathology,...

Jan 1 2025 40438598
Artificial intelligence based advancements in nanomedicine for brain disorder management: an updated narrative review.

Nanomedicines are nanoscale, biocompatible materials that offer promising alternatives to conventional treatment options for brain disorders. The rece...

Jan 1 2025 40432717
Machine learning identifies genes linked to neurological disorders induced by equine encephalitis viruses, traumatic brain injuries, and organophosphorus nerve agents.

Venezuelan, eastern, and western equine encephalitis viruses (collectively referred to as equine encephalitis viruses---EEV) cause serious neurologica...

Jan 1 2025 40433315
Fully automated MRI-based analysis of the locus coeruleus in aging and Alzheimer's disease dementia using ELSI-Net.

INTRODUCTION: The locus coeruleus (LC) is linked to the development and pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD)...

Jan 1 2025 40365469
Identifying EEG biomarkers of sense of embodiment in virtual reality: insights from spatio-spectral features.

The Sense of Embodiment (SoE) refers to the subjective experience of perceiving a non-biological body part as one's own. Virtual Reality (VR) provides...

Jan 1 2025 40420994
Significance and mechanisms of perineural invasion in malignant tumors.

Cancer remains the second leading cause of death worldwide. Tumor invasion and metastasis pose significant challenges for clinical management. In addi...

Jan 1 2025 40421086
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