Oncology/Hematology

Latest AI and machine learning research in oncology/hematology for healthcare professionals.

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Transforming Gynecologic Cancer Care Through Artificial Intelligence: A Clinician's Guide to the Evolving Landscape.

Artificial intelligence (AI) is rapidly reshaping gynecologic oncology across the continuum of care. This clinician-focused review synthesizes current evidence for AI-enabled prevention and screening (HPV-informed risk models, AI-assisted colposcopy), early detection and diagnosis (radiomics, liquid biopsy, and digital pathology), prognosis and risk prediction (multimodal models integrating clinic...

Dec 9 2025 41363042

An Exosome-Based Liquid Biopsy for the Detection of Early-Onset Colorectal Cancer: The ENCODER Multicenter Study.

BACKGROUND & AIMS: The incidence of early-onset colorectal cancer (EOCRC; diagnosed before age 50 years) continues to increase, now standing as the leading cause of cancer-related deaths in young men. Screening participation in young adults remains low, but a noninvasive test may help. METHODS: Early Onset Colorectal Cancer Detection (ENCODER) was an international, multicentric cohort study involv...

Dec 9 2025 41364052
CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.

Epigenetic macromolecular enzyme complexes tightly regulate gene expression at the chromatin level and have recently been found to colocalize with RNA...

Dec 9 2025 41364533
Multimodal AI generates virtual population for tumor microenvironment modeling.

The tumor immune microenvironment (TIME) critically impacts cancer progression and immunotherapy response. Multiplex immunofluorescence (mIF) is a pow...

Dec 9 2025 41371214
Advancements in the study of exosomes in disease diagnosis and treatment.

Exosomes are small, membrane-enclosed vesicles that can originate from a variety of sources and contain a wealth of material. They are involved in phy...

Dec 9 2025 41380924
Deep learning algorithm assisting diagnosis of prostate cancer extracapsular extension based on [18F]PSMA-1007 PET/CT and multiparametric MRI: A multicenter study.

BACKGROUND: This study aimed to develop and validate deep learning (DL) models based on multiparametric MRI (mpMRI) and [18F]PSMA-1007 PET/CT to predi...

Dec 8 2025 41361534
Establishment of CT diagnostic reference levels (DRLs) in Tokyo.

OBJECTIVE: Diagnostic reference levels (DRLs) are essential for optimizing radiation dose in CT examinations. However, current DRLs may not reflect th...

Dec 8 2025 41359161
ChatGPT-4o as a diagnostic tool for skin cancer: Diagnostic accuracy in melanoma and non-melanoma detection.

INTRODUCTION: The global incidence of skin cancer is rising, emphasizing the need for early detection tools. Artificial intelligence (AI) models, incl...

Dec 8 2025 41355746
Transcriptome-wide RNA Stability Across Cancers Reveals Therapeutic Vulnerabilities.

The steady-state abundance of mRNA is governed by the interplay between transcription and degradation, yet the contribution of RNA stability to cancer...

Dec 8 2025 41371605
Mri-based habitat and peritumoral radiomics for predicting the proliferative activity of stromal cells in giant cell tumor of bone.

PURPOSE: This study aims to explore the feasibility of MRI-based habitat and peritumoral radiomics for predicting the proliferative activity of stroma...

Dec 8 2025 41479686
Immunocto: A massive immune cell database auto-generated for histopathology.

With the advent of novel cancer treatment options such as immunotherapy, studying the tumour immune micro-environment (TIME) is crucial to inform on p...

Dec 7 2025 41401636
Design of the first national lung cancer screening program in the European Union: the Croatian Model.

OBJECTIVES: To address Croatia's high lung cancer mortality and late-stage diagnoses, the Ministry of Health initiated a multidisciplinary effort to d...

Dec 6 2025 41351704
Stability control of metastable states as a unified mechanism for flexible temporal modulation in cognitive processing.

Flexible modulation of temporal dynamics in neural sequences underlies many cognitive processes. For instance, we can adaptively change the speed of m...

Dec 6 2025 41401600
Profiling the Braak progression in Parkinson's disease: a transcriptomics and ML driven identification of progressive biomarker and prognostic ceRNA signature.

Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is marked by dopaminergic neuron loss and α-synuclein aggregation. Alt...

Dec 6 2025 41360364
Attention-Guided Deep Learning of Chemical Exchange Saturation Transfer Magnetic Resonance Imaging to Differentiate Between Tumor Progression and Radiation Necrosis in Brain Metastasis.

PURPOSE: Stereotactic radiosurgery (SRS) is a standard treatment for brain metastases; however, it may lead to radiation necrosis (RN). RN can be virt...

Dec 5 2025 41348074
Deep Learning for Differentiating Benign From Malignant Bile Duct Dilation on MRCP: Development and Prospective Evaluation of an Xception-Logistic Regression Ensemble Model.

BACKGROUND: Accurate identification of benign and malignant bile duct dilatation (BDD) is needed to determine its management plan. Conventional imagin...

Dec 5 2025 41348562
Application of Machine learning in predicting cancer complications using longitudinal Data: A systematic review and Meta-Analysis.

Cancer prognosis of complications like metastasis, recurrence, and side effects of treatments is important to enhance patient prognosis. There is grea...

Dec 5 2025 41422795
Low-dose CBCT image reconstruction: a review.

Cone-beam computed tomography (CBCT) is a critical imaging modality in various medical fields, yet its repeated use poses radiation risks to patients....

Dec 5 2025 41348234
Artificial Intelligence in Prostate MRI: Addressing Current Limitations Through Emerging Technologies.

Prostate MRI has transformed lesion detection and risk stratification in prostate cancer, but its impact is constrained by the high cost of the exam, ...

Dec 5 2025 41348934
Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review).

Prostate cancer remains one of the most prevalent malignancies and a major cause of cancer‑related mortality among men worldwide. Despite widespread u...

Dec 5 2025 41347816
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