Oncology/Hematology

Latest AI and machine learning research in oncology/hematology for healthcare professionals.

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Prediction of pathological grade of oral squamous cell carcinoma and construction of prognostic model based on deep learning algorithm.

The aim of this study is to establish a deep learning model for predicting the pathological grade of oral squamous cell carcinoma(OSCC) based on whole slide images (WSIs). The histopathological images of 257 patients with OSCC were downloaded from TCGA database and randomly divided into training set, validation set and test set at a ratio of 7:2:1. The CPTAC-OSCC dataset, which contains 165 pathol...

Jun 1 2025 40450613

Global trends and characteristics of metal-organic frameworks in cancer research: a machine-learning-based bibliometric analysis.

BACKGROUND: Cancer poses a significant health threat, causing millions of deaths annually. Although chemotherapy-based comprehensive therapies are common, their low accuracy and severe side effects limit effectiveness. Metal-organic frameworks (MOFs), with their superior biocompatibility and stability, show great promise for drug delivery and cancer treatment. This study aims to explore the potent...

Jun 1 2025 40450655
Targeting INF2 with DiosMetin 7-O-β-D-Glucuronide: a new stratagem for colorectal cancer therapy.

BACKGROUND AND PURPOSE: Colorectal cancer (CRC) is the third most prevalent malignancy in the gastrointestinal tract and the second leading cause of c...

Jun 1 2025 40452021
Performance of AI methods in PET-based imaging for outcome prediction in lymphoma: A systematic review and meta-analysis.

OBJECTIVES: To evaluate the predictive performance of artificial intelligence (AI) methods using pre-treatment PET-based imaging for outcome predictio...

Jun 1 2025 40466216
Tumor-specific draining lymph node CD8 T cells orchestrate an anti-tumor response to neoadjuvant PD-1 immune checkpoint blockade.

Elucidating the anti-tumor role of tumor-draining lymph nodes (tdLNs) in patients could offer critical mechanistic insight and shift therapeutic strat...

Jun 1 2025 40501950
From Molecular Precision to Clinical Practice: A Comprehensive Review of Bispecific and Trispecific Antibodies in Hematologic Malignancies.

Multispecific antibodies have redefined the immunotherapeutic landscape in hematologic malignancies. Bispecific antibodies (BsAbs), which redirect cyt...

Jun 1 2025 40508128
Multi-omics identifies OSM-OSMR as a key receptor-ligand in the tumor environment of endometrial adenocarcinoma.

Endometrial adenocarcinoma carries a bleak prognosis, and the molecular markers that evaluate the progression of endometrial adenocarcinoma to advance...

May 31 2025 40450916
Anoikis in hepatocellular carcinoma: genetic alterations and immune microenvironment insights from single-cell and computational analysis.

BACKGROUND: Hepatocellular carcinoma (HCC) is characterized by high heterogeneity, and its molecular features and microenvironment complexity contribu...

May 31 2025 40447878
Relationship between spleen volume and diameter for assessment of response to treatment on CT in patients with hematologic malignancies enrolled in clinical trials.

PURPOSE: Investigate spleen diameter (d) and volume (v) relationship in patients with hematologic malignancies (HM) by determining volumetric threshol...

May 31 2025 40448843
NeoPred: dual-phase CT AI forecasts pathologic response to neoadjuvant chemo-immunotherapy in NSCLC.

BACKGROUND: Accurate preoperative prediction of major pathological response or pathological complete response after neoadjuvant chemo-immunotherapy re...

May 31 2025 40449955
Identification of multiomics and immune infiltration-associated biomarkers for early gastric cancer: a machine learning-based diagnostic model development study.

BACKGROUND: Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, with early diagnosis remaining a significant challenge. Availab...

May 31 2025 40450287
Development and interpretation of a pathomics-based model for the prediction of immune therapy response in colorectal cancer.

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide, with a 5-year survival ra...

May 31 2025 40456461
Discriminating Clear Cell From Non-Clear Cell Renal Cell Carcinoma: A Machine Learning Approach Using Contrast-enhanced Ultrasound Radiomics.

OBJECTIVE: The aim of this investigation is to assess the clinical usefulness of a machine learning model using contrast-enhanced ultrasound (CEUS) ra...

May 31 2025 40450509
A NOVEL MACHINE LEARNING APPROACH FOR TUMOR DETECTION BASED ON TELOMERIC SIGNATURES.

Cancer remains one of the most complex diseases faced by humanity, with over 200 distinct types, each characterized by unique molecular profiles that ...

May 31 2025 40502195
Development and Validation of a Lifestyle-Based 10-Year Risk Prediction Model of Colorectal Cancer for Early Stratification: Evidence from a Longitudinal Screening Cohort in China.

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with growing evidence linking risk to lifestyle and ...

May 31 2025 40507167
Mechanical Modulation, Physiological Roles, and Imaging Innovations of Intercellular Calcium Waves in Living Systems.

Long-range intercellular communication is essential for multicellular biological systems to regulate multiscale cell-cell interactions and maintain li...

May 31 2025 40507332
Monte Carlo and Machine Learning-Based Evaluation of Fe-Enriched Al Alloys for Nuclear Radiation Shielding Applications.

This study presents a hybrid computational investigation into the radiation shielding behavior of Fe-enriched Al-based alloys (Al-Fe-Mo-Si-Zr) for pot...

May 31 2025 40508579
Predicting Resistance and Survival of HCC Patients Post-HAIC: Based on Shapley Additive exPlanations and Machine Learning.

PURPOSE: To establish prediction models using Shapley Additive exPlanations (SHAP) and multiple machine learning (ML) algorithms to identify clinical ...

May 31 2025 40475092
Prediction of Ligand-Receptor Interactions Based on CatBoost and Deep Forest and Their Application in Cell-Cell Communication Analysis.

Cell-to-cell communication (CCC) is prominent for cell growth and development as well as tissue and organ formation. CCC inference can help us to deep...

May 30 2025 40444832
Prediction of Lymph Node Metastasis in Non-Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data.

PURPOSE: Lymph node metastasis (LNM) significantly affects prognosis and treatment strategies in non-small cell lung cancer (NSCLC). Current diagnosti...

May 30 2025 40446175
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