Oncology/Hematology

A deep-learning model to predict the completeness of cytoreductive surgery in colorectal cancer with peritoneal metastasis☆.

BACKGROUND: Colorectal cancer (CRC) with peritoneal metastasis (PM) is associated with poor prognosis. The Peritoneal Cancer Index (PCI) is used to evaluate the extent of PM and to select Cytoreductive Surgery (CRS). However, PCI score is not accurate to guide patient's selection for CRS.

Nano biosensor unlocks tumor derived immune signals for the early detection of ovarian cancer.

Ovarian cancer is a critical health issue for women nowadays. Its impact is significant because of its high mortality rate (324,603 worldwide), late-stage diagnosis and poor survival rate. Lack of screening tests, vague symptoms, misdiagnosis, and age factor makes it even more difficult to detect. Neutrophils, a subset of immune cells, undergo tumor-specific changes as ovarian cancer progresses in...

Early prediction of cardiovascular events following treatments in female breast cancer patients: Application of real-world data and artificial intelligence.

• Application of real-world data and artificial intelligence in detecting cardiotoxicity following cancer treatment. • Clinical features have been use...

Innovative construction and application of bile duct organoids: Unraveling the complexity of bile duct diseases and potential therapeutic strategies.

The biliary system is crucial for liver function, regulating bile production, secretion, and transport. Dysfunctions within this system can lead to va...

Introduction of a hybrid approach based on statistical shape model and Adaptive Neural Fuzzy Inference System (ANFIS) to assess dosimetry uncertainty: A Monte Carlo study.

The increasing use of ionizing radiation has raised concerns about adverse and long-term health risks for individuals. Therefore, to evaluate the rang...

Enhancing pancreatic cancer diagnostics: Ensemble-based model for automated urine biomarker classification.

This research addresses the critical challenge of early detection in pancreatic ductal adenocarcinoma (PDAC) by exploring urinary biomarkers and integ...

Validation of patient-specific deep learning markerless lung tumor tracking aided by 4DCBCT.

. Tracking tumors with multi-leaf collimators and x-ray imaging can be a cost-effective motion management method to reduce internal target volume marg...

Cancer Drug Sensitivity Prediction Based on Deep Transfer Learning.

In recent years, many approved drugs have been discovered using phenotypic screening, which elaborates the exact mechanisms of action or molecular tar...

Direct-to-Treatment Adaptive Radiation Therapy: Live Planning of Spine Metastases Using Novel Cone Beam Computed Tomography.

PURPOSE: Cone beam computed tomography (CBCT)-based online adaptive radiation therapy is carried out using a synthetic CT (sCT) created through deform...

The accuracy of artificial intelligence in the diagnosis of soft tissue sarcoma: A systematic review and meta-analysis.

Harnessing Artificial Intelligence for Precision Diagnosis and Treatment of Triple Negative Breast Cancer.

Triple-Negative Breast Cancer (TNBC) is a highly aggressive subtype of breast cancer (BC) characterized by the absence of estrogen, progesterone, and ...

Transcriptome analysis reveals the potential role of neural factor EN1 for long-terms survival in estrogen receptor-independent breast cancer.

Breast cancer patients with estrogen receptor-negative (ERneg) status, encompassing triple negative breast cancer (TNBC) and human epidermal growth fa...

Artificial intelligence and whole slide imaging, a new tool for the microsatellite instability prediction in colorectal cancer: Friend or foe?

Colorectal cancer (CRC) is the third most common and second most deadly cancer worldwide. Despite advances in screening and treatment, CRC is heteroge...

Development and validation of computer-aided detection for colorectal neoplasms using deep learning incorporated with computed tomography colonography.

OBJECTIVES: Computed tomography (CT) colonography is increasingly recognized as a valuable modality for diagnosing colorectal lesions, however, the in...

Self-supervised learning reveals clinically relevant histomorphological patterns for therapeutic strategies in colon cancer.

Self-supervised learning (SSL) automates the extraction and interpretation of histopathology features on unannotated hematoxylin-eosin-stained whole s...

Prediction of tumor spread through air spaces with an automatic segmentation deep learning model in peripheral stage I lung adenocarcinoma.

BACKGROUND: To evaluate the clinical applicability of deep learning (DL) models based on automatic segmentation in preoperatively predicting tumor spr...

Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer.

Understanding the prognosis of cancer patients is crucial for enabling precise diagnosis and treatment by clinical practitioners. Multimodal fusion mo...

Integrating local and global attention mechanisms for enhanced oral cancer detection and explainability.

BACKGROUND AND OBJECTIVE: Early detection of Oral Squamous Cell Carcinoma (OSCC) improves survival rates, but traditional diagnostic methods often pro...

Identification of Novel Fourth-Generation Allosteric Inhibitors Targeting Inactive State of EGFR T790M/L858R/C797S and T790M/L858R Mutations: A Combined Machine Learning and Molecular Dynamics Approach.

Targeted therapy with an allosteric inhibitor (AIs) is an important area of research in patients with epidermal growth factor receptor (EGFR) mutation...

Role of oxidative balance score in staging and mortality risk of cardiovascular-kidney-metabolic syndrome: Insights from traditional and machine learning approaches.

OBJECTIVES: To evaluate the roles of oxidative balance score (OBS) in staging and mortality risk of cardiovascular-kidney-metabolic syndrome (CKM).