Osteoporosis

Resting-State Functional MRI Reveals Altered Seed-Based Connectivity in Diabetic Osteoporosis Patients.

BACKGROUND: Diabetic osteoporosis (DOP) can cause abnormal brain neural activity, but its mechanism is still unclear. This study aims to further explore the abnormal functional connectivity between different brain regions based on the team's previous research.

Excellent absorption-dominant electromagnetic interference shielding performances of asymmetric gradient layered composite films exploited with assistance of machine learning.

Developing high-performance absorption-dominant electromagnetic interference (EMI) shielding composites is essential yet challenging for advanced high-power electronic devices to minimize the second EMI radiation. Traditional experiment-based approaches for shielding material exploitation usually require extensive fabrication and characterization procedures, leading to a long duration and high exp...

Simplified two-compartment neuron with calcium dynamics capturing brain-state specific apical-amplification, -isolation and -drive.

Mounting experimental evidence suggests the hypothesis that brain-state-specific neural mechanisms, supported by the connectome shaped by evolution, c...

Uncemented hip arthroplasty and denosumab: increased postoperative dipeptide concentrations and identification of potential new bone turnover biomarkers.

Denosumab is a potent antagonist of RANKL and is widely used to treat severe postmenopausal osteoporosis. Using high-resolution mass spectrometry (HRM...

Layer-Specific Colocalization of Microglia with Amyloid Plaques in the Middle Temporal Gyrus Predicts Cognitive Decline in Alzheimer's Disease.

Alzheimer's disease (AD), the most common form of dementia, is marked by cognitive decline and amyloid-beta (Aβ) plaque deposition in the brain. Micro...

Evaluating safe infrared neural stimulation parameters: Calcium dynamics and excitotoxicity thresholds in dorsal root ganglia neurons.

BACKGROUND: As a promising neural stimulation technique, infrared neural stimulation (INS) has recently gained significant attention due to its abilit...

AI-based volumetric six-tissue body composition quantification from CT cardiac attenuation scans for mortality prediction: a multicentre study.

BACKGROUND: CT attenuation correction (CTAC) scans are routinely obtained during cardiac perfusion imaging, but currently only used for attenuation co...

Associations between calcium intake and T cell infiltration in colorectal tumours.

Higher T cell infiltration in colorectal tumours has been associated with better prognosis. Evidence indicates that calcium signalling is essential fo...

Longitudinal changes in minerals are influenced by immunosuppressive treatment in men with granuloma disease.

PURPOSE: To investigate whether granuloma formation following self-administered cosmetic oil injections affects mineral homeostasis, specifically calc...

Multi-technique computational assessment of fluoride uptake in enamel using PIGE, NEXAFS, and Raman spectroscopy.

The uptake of fluoride in the enamel matrix is an effective strategy to prevent demineralization and caries formation. In this study a comprehensive m...

Optimization of process conditions and kinetic microbial growth for milk fermentation using domestic kefir grains from Costa Rica.

Kefir, a fermented milk product, differs from yogurt due to its unique microbial composition, offering a broad spectrum of health benefits. Given its ...

Sex-specific associations between exposure to metal mixtures and mitochondrial DNA copy number: A repeated-measures study.

Few repeated-measures studies with multiple time points have evaluated the sex-specific association between mitochondrial DNA copy number (mtDNAcn) an...

Branding a New Technological Outlook for Future Orthopaedics.

Orthopedics is undergoing a transformative shift driven by personalized medical technologies that enhance precision, efficiency, and patient outcomes....

Impact of the recent advances in coronary artery disease imaging on pilot medical certification and aviation safety: current state and future perspective.

Coronary artery disease (CAD) is highly prevalent among pilots due to the nature of their lifestyle, and occupational stresses. CAD is one the most co...

Machine learning approaches reveal methylation signatures associated with pediatric acute myeloid leukemia recurrence.

Acute myeloid leukemia (AML) is a severe hematological malignancy characterized by high recurrence rates, especially in pediatric patients, highlighti...

Multiscale simulations that incorporate patient-specific neural network models of platelet calcium signaling predict diverse thrombotic outcomes under flow.

During thrombosis, platelets rapidly deposit and activate on the vessel wall, driving conditions such as myocardial infarction and stroke. The complex...

The Role of Computed Tomography and Artificial Intelligence in Evaluating the Comorbidities of Chronic Obstructive Pulmonary Disease: A One-Stop CT Scanning for Lung Cancer Screening.

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Comorbidities in patients with COPD significantly ...

Unraveling soil salinity on potentially toxic element accumulation in coastal Phragmites australis: A novel integration of multivariate and interpretable machine-learning models.

Revealing the key mechanisms influencing the behavior of potentially toxic elements (PTEs) in soil-plant systems is of great significance for environm...

Surgical and radiological outcomes of giant cell tumor of the bone: prognostic value of Campanacci grading and selective use of denosumab.

BACKGROUND: Advancements in diagnostic and therapeutic modalities for giant cell tumors of bone (GCTB) have introduced molecular and radiological tool...

Deep Learning-enhanced Opportunistic Osteoporosis Screening in Ultralow-Voltage (80 kV) Chest CT: A Preliminary Study.

RATIONALE AND OBJECTIVES: To explore the feasibility of deep learning (DL)-enhanced, fully automated bone mineral density (BMD) measurement using the ...