Pain Management

Latest AI and machine learning research in pain management for healthcare professionals.

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Evaluation of Deep Learning Algorithms to Predict Multiple Dementia-Related Neuropathologies from Brain MRI, Clinical and Genetic Data

Alzheimer’s disease and related dementias (ADRD) involve overlapping neurodegenerative and vascular ...

Toward Unified Biomarkers for Focal Epilepsy

Accurately localizing the epileptogenic network (EpiNet) remains a major barrier to effective epilep...

A Hybrid Knowledge- and Data-driven Model for Automatic Assessment of Chemically Induced Spiking Patterns in C-fiber Microneurography

Analyzing temporal spike patterns in nociceptors recorded via microneurography is challenging due to...

Multi-Class Classification of Cannabis and Alcohol Use Disorder: Identifying Common and Substance-Specific Neural Circuits

Machine learning approaches have advanced the identification of neural signatures of substance use, ...

Theta and gamma transcranial alternating current stimulation modulate Mandarin consonant and lexical tone perception

A theta/gamma oscillatory neural mechanism has been postulated to explain the auditory sampling of h...

A blueprint for mutation-defined hallmark vulnerabilities across human cancers

Hallmark gene mutations shape cancer cell vulnerabilities and inform drug discovery1–3. A systematic...

Machine Learning Guided Video Analysis Identifies Sound-Evoked Pain Behaviors from Facial Grimace and Body Cues in Mice

Humans can experience auditory pain in response to sound, either from extremely loud noise or in cas...

Cancer target discovery enabled by transcriptome-based virtual CRISPR screening

Functional genetic screens have uncovered dependencies in many cancers, but experimentally screened ...

A validated set of neural gene reporter mice and chemical tracers tools for mapping knee innervating neurons

Joint pain is an increasing concern for our aging population, as current therapies to slow joint dis...

Reward-induced endogenous pain inhibition scales with action-outcome certainty in humans

Endogenous pain modulation is thought to encompass a crucial evolutionary purpose in guiding decisio...

Stable Somatotopy in Chronic Low Back Pain: Is Cortical Map Reorganization a Myth?

Chronic low back pain (CLBP) has been linked to maladaptive cortical plasticity in sensorimotor regi...

A unified model of short- and long-term plasticity: Effects on network connectivity and information capacity

Activity-dependent synaptic plasticity is a fundamental learning mechanism that shapes connectivity ...

Executive Resources Shape the Impact of Language Predictability Across the Adult Lifespan

Humans routinely anticipate upcoming language, but whether such predictions come at a cognitive cost...

Evo2HiC: a multimodal foundation model for integrative analysis of genome sequence and architecture

Understanding how genomic sequences shape three-dimensional (3D) genome architecture is funda-mental...

qcGEM: a graph-based molecular representation with quantum chemistry awareness

The advancement of artificial intelligence (AI) has reshaped drug discovery. AI-based models typical...

Genetic Influences on Neural Responses in Placebo Analgesia Circuitry

Placebo analgesia is a well-established medical phenomenon with overlapping neural representations b...

Non-invasive vagus nerve stimulation modulates Pavlovian bias in a state-dependent manner

The vagus nerve transmits vital signals between organ systems of the body and the brain. Despite gro...

BCL-XL Dependence is a Subtype Agnostic Actionable Feature of Difficult-to-Treat Kidney Cancers

The BCL-XL anti-apoptotic protein is a clear cell Renal Cell Carcinoma (ccRCC) dependency; however, ...

Leveraging Hand-Crafted Radiomics on Multicenter FLAIR MRI for Predicting Disability Progression in People with Multiple Sclerosis

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that results i...

Integrating Multidimensional Data Analytics for Precision Diagnosis of Chronic Low Back Pain

Low back pain (LBP) is a leading cause of disability worldwide, with up to 25% of cases become chron...

The genetics of TDP43-Type-C neurodegeneration: a whole genome sequencing study

Frontotemporal lobar degeneration-TDP Type C (TDP-C) is a unique neurodegenerative disease that star...

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