Pancreatic Diseases

Risk classification of oral potentially malignant disorders (OPMDs) using explainable machine learning through a community-based cross-sectional study in rural India.

BACKGROUND: Oral cancer is a major public health problem among the population of India. In rural setting whereby there is exposure to high-risk factors associated with tobacco use and low accessibility to structured screening services. Though visual oral examination has been proven to be effective in lowering mortality rates of oral cancer, population-based screening has not only been found to be ...

Klf4-Tymp axis promotes inflammation-driven early tumorigenesis by enhancing kras mutation-induced acinar-to-ductal metaplasia through Pi3k/Akt and Mek/Erk pathways.

BACKGROUND: Acinar-to-ductal metaplasia (ADM) is a pivotal step in pancreatic tumorigenesis, reversible in normal contexts but progressing to PanIN and pancreatic cancer (PC) in the presence of Kras mutation and inflammation. Thus, delineating exocrine cell heterogeneity and identifying regulators of ADM are essential for understanding pancreatic tumorigenesis. METHODS: We collected single-cell RN...

Deep learning-powered quantification of endocrine cells and CD3+ T cells in the natural history of type 1 diabetes.

AIMS/HYPOTHESIS: Histopathological analysis in type 1 diabetes presents challenges in achieving precise characterisation with cellular quantification ...

Pancreatic cancer.

Pancreatic ductal adenocarcinoma remains one of the deadliest malignancies, characterized by late diagnosis, aggressive biology and limited therapeuti...

Machine learning-based prognostic signature integrating mitochondrial function and programmed cell death patterns in pancreatic adenocarcinoma.

The interplay between mitochondria and programmed cell deaths (PCD) is associated with tumor pathogenesis. However, the specific roles of genes relate...

Cumulative stress hyperglycemia ratio exposure and dynamic trajectories reveal prognostic determinants of acute hyperlipidemic pancreatitis: an 5-year cohort study.

BACKGROUND: The stress hyperglycemia ratio (SHR) and glycemic variability (GV) both reflect acute glycemic fluctuations, with established roles in car...

Genetics of bipolar disorder: Translating discoveries to biological insights and clinical decision support.

Bipolar disorder (BD) is a clinically heterogenous mental disorder with a diversity in clinical trajectories and treatment response. Twin studies have...

CARES-Net: a channel-attention residual network for multi-disease classification in small-sample 1H NMR metabolomics data.

BACKGROUND: NMR-based metabolomics is widely used in disease diagnosis due to its non-destructive and quantitative advantages. However, its analytical...

Applying Artificial Intelligence Technologies to Detect Pancreatic Ductal Adenocarcinoma Using Routine Laboratory Tests: A Pilot Study with the Aid of Machine Learning Suitable for a Small Data Analysis.

Objective This study aimed to investigate whether artificial intelligence could identify pancreatic ductal adenocarcinoma (PDAC) in patients aged <70 ...

Global Trends in Postoperative Sepsis After Pancreatoduodenectomy: A Bibliometric Analysis.

INTRODUCTION: Postoperative sepsis after pancreatoduodenectomy (PSPD) remains a major determinant of morbidity and mortality. Although extensive clini...

An epidemiological study of Parkinson's disease in Chinese older adults using the Global Burden of Disease and China Health and Retirement Longitudinal Study databases.

INTRODUCTION: The prevalence of Parkinson's disease (PD) has increased globally, especially in China, and emerged as a critical public health challeng...

Regional disparities and metabolic determinants of type 2 diabetes in women aged 55 and older.

OBJECTIVE: To assess long-term trends, regional disparities, determinants, and quality of care for type 2 diabetes mellitus (T2DM) among women aged 55...

Pancreatic tumor detection in computed tomography images through a rotary positional siamese vision transformer.

Vision Transformers (ViTs) are one of the powerful tools in medical imaging, providing new possibilities for pancreatic cancer diagnosis. In recent ye...

Dynamic changes in gut microbiota and discovery of prognostic biomarkers in locally advanced pancreatic cancer during chemoradiotherapy.

UNLABELLED: Pancreatic cancer has an exceptionally poor prognosis, with the majority of cases diagnosed at an advanced stage. Concurrent chemoradiothe...

Physician Perspectives on ChatGPT-4o as a Patient Resource for Abdominal Cancer Surgeries: Cross-Sectional Survey.

BACKGROUND: Artificial intelligence (AI) models are being increasingly integrated into clinical care. Moreover, the availability of publicly accessibl...

Sex-specific microbial and tryptophan signatures of depression implicate archaeal methanogens and indole-3-acetic acid only in women.

Sex differences in mental health are often overlooked, yet gut microbiota-host metabolite interactions may contribute to sexual dimorphism in depressi...

Artificial intelligence: Catalyzing a new era in pancreatic cancer cure.

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, mostly due to its insidious onset that consequently leads to dia...

Interpretable LightGBM model for predicting postoperative gastrointestinal hemorrhage in elderly hip fracture patients: leveraging systemic inflammation and medication exposures for personalized risk stratification.

BACKGROUND: Postoperative gastrointestinal (GI) bleeding is a serious complication after hip fracture surgery in older adults, yet perioperative risk ...

Speech-based system for detecting alcohol intoxication using optimized deep learning.

In this research, we propose a highly accurate speech-based system for detecting alcohol intoxication, utilizing deep learning algorithms to classify ...

Impact of Artificial Intelligence-Assisted Endoscopy on Screening for Upper Gastrointestinal Cancer in a Large-Scale Health Screening Facility.

OBJECTIVES: Artificial intelligence (AI)-assisted endoscopy has been developed for the early detection of upper gastrointestinal cancer; however, its ...