Pancreatic Diseases

Spatially Resolved Proteomic Cartography Illuminates the Earliest Molecular Programs in Pancreatic Cancer Evolution.

Min, Schweizer, and colleagues use artificial intelligence-powered deep visual proteomics to generate a spatial proteomic atlas of pancreatic cancer precursor evolution, revealing that major metabolic and inflammatory reprogramming occurs long before overt histologic transformation. More broadly, the study highlights the emerging potential of spatial proteomics and multiomics to bridge histopathol...

Explanation-Guided Reconstruction of Missing Clinical Features for Survival Prediction in Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers, with survival rates influenced by a variety of factors, including early diagnosis, tumor profile, treatment regimen, and treatment response. The development of PDAC prognostic models is often compromised by incomplete clinical records that need to cover imaging, pathology, surgery, and treatment workflows. We propose a...

Impact of artificial intelligence intervention on awareness of anatomical landmarks in laparoscopic gastrectomy: An exploratory study.

BACKGROUND: We have developed gastric cancer/gastrectomy artificial intelligence (gAI) that leverages the tacit knowledge of experienced surgeons to v...

Machine-learning prediction of affinity and epistasis in the bovine pancreatic trypsin inhibitor-chymotrypsin complex.

Protein-protein interactions (PPIs) are shaped by evolutionary pressures that fine-tune binding affinities and drive the epistatic relationships that ...

Bayesian Machine Learning Tools for Alcohol Use Disorder Research: The bpaup R Package.

Alcohol use disorder (AUD) research faces significant challenges in capturing individual heterogeneity and complex temporal patterns in drinking behav...

APEX-NET: automated pancreatic evaluation network using early non-contrast CT.

OBJECTIVES: To develop and validate APEX-NET for early diagnosis and severity stratification of acute pancreatitis (AP) using non-contrast CT (NCCT), ...

OpenDicomViewer: A Lightweight Open-Source DICOM Viewer for macOS Built with Swift.

Digital Imaging and Communications in Medicine (DICOM) viewers are essential tools in clinical practice, yet established open-source macOS viewers suc...

Large Language Model Versus Multidisciplinary Team: Feasibility Study of Pancreatic Cancer Management Recommendations.

Of 269 pancreatic cancer multidisciplinary team cases, 125 complete structured cases were evaluated. The chat interface model labeled ChatGPT-5.2 matc...

Evolving techniques to optimize ERCP-based sampling and evaluation of malignant biliary strictures.

Endoscopic retrograde cholangiopancreatography (ERCP)-based tissue acquisition is the cornerstone for assessment of suspected malignant biliary strict...

Dual cross-attentive mutual teaching for semi-supervised 3D medical segmentation.

Semi-supervised learning can reduce the dependence on large-scale labeled data in 3D medical image segmentation.In this work, we propose a new Dual Cr...

Oxygen 1s photoelectron spectroscopy of gaseous alcohols and the σ-inductive properties of alkyl groups.

This study presents a comprehensive investigation of alcohol molecules in the gas phase using oxygen 1s X-ray photoelectron spectroscopy (O1s XPS), co...

Benchmarking docking and ML re-scoring screening performance for KRAS G12D in pancreatic cancer.

The KRAS G12D mutation is commonly found in pancreatic cancer and is integral to the cell signaling pathway, making it a critical target for drug deve...

Elucidating the pathway activity and prognostic significance of diverse regulatory cell death patterns in pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a five-year survival rate below 10%. Regulatory cell death (RCD) plays ...

Pan-cancer analysis identifies immunoproteasome as the predominant survival-associated component of antigen processing machinery.

Neoantigens are critical targets for cancer immunotherapy, yet the relationship between experimentally validated neoantigen burden and antigen process...

[Computational medicine empowers multi-dimensional diagnosis and treatment of pancreatic cancer].

Due to its high genomic heterogeneity and dense desmoplastic microenvironment, traditional diagnosis and treatment for pancreatic ductal adenocarcinom...

[Arterial variations and management strategies in pancreatic surgery].

The pancreas is local in the retroperitoneal space,in close proximity to critical blood vessels such as celiac trunk, superior mesenteric artery, hepa...

When Wrong Answers Matter: Consequence-Weighted Evaluation of Large Language Models for ERCP Triage.

BackgroundLarge language models (LLMs) increasingly generate clinical recommendations, but their ability to translate biliary guidelines into safe pro...

Comment on "Toward Timely Diagnosis of Pancreatic Cancer: Revolutionizing Early Detection Through Genomics, Artificial Intelligence, and Noninvasive Biomarkers".

A bibliometric analysis of research trends and future directions in early detection of pancreatic cancer.

BACKGROUND: Research on the early detection of pancreatic cancer has grown rapidly in recent years; however, existing bibliometric studies in this fie...

An interpretable XGboost algorithm for predicting 30-day mortality in acute pancreatitis using routine biomarkers.

OBJECTIVE: To develop and validate a machine learning (ML) algorithm for predicting 30-day mortality in adult patients with acute pancreatitis (AP) us...