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Brain organoids in environmental neurotoxicology: applications, mechanisms, and future perspectives.

The advent of human induced pluripotent stem cell (hiPSC)-derived brain organoids represents a significant advance in environmental neurotoxicology, propelling the discipline toward human-relevant, mechanistic, and predictive in vitro paradigms. This review explores the utility of brain organoids in environmental neurotoxicology, which uniquely address critical limitations of traditional models by...

Antioxidant vitamin index and risk of age-related macular degeneration: multicenter validation and clinical translation.

Age-related macular degeneration (AMD) is a leading cause of blindness in older adults, with oxidative stress as a central driver. We proposed the Antioxidant Vitamin Index (AVI), a composite indicator integrating vitamins A, C, and E to quantify systemic antioxidant nutritional status, and evaluated its association with AMD across three large cohorts: the UK Biobank, NHANES 2005-2008, and a Tianj...

Multidimensional analysis of postoperative nursing challenges in oral cancer surgery: a retrospective study of 245 patients and proposal of the PROTECT mode.

PURPOSE: The quality of postoperative care for oral tumors critically influences patient prognosis and quality of life; however, current nursing syste...

Generative AI dependence in higher education: A PLS-SEM examination of Chinese and Malaysian teachers through the I-PACE model.

Drawing on the Interaction of Person-Affect-Cognition-Execution (I-PACE) model, this study addresses a current gap in the understanding of how affecti...

Development of an artificial intelligence platform to improve compliance in periodontal maintenance patients: A proof-of-concept study.

BACKGROUND: The purpose of this study is to report on the development of an artificial intelligence (AI) model designed to improve compliance in perio...

From fermentation to function: a critical review of lactic acid bacteria redesign for functional foods and precision nutrition.

Lactic acid bacteria (LAB) have transitioned from their traditional roles in food preservation and flavor enhancement to more advanced applications su...

Analysis of Associated Factors and Construction of Risk Prediction Models for Frailty in Hospitalized Older Adults Living With HIV: Protocol for a Prospective Observational Study.

BACKGROUND: The aging trend of people living with HIV or AIDS in China is increasing day by day. Frailty is a common condition among older adults livi...

Artificial intelligence in head and neck cancer rehabilitation services: current state and future perspectives.

PURPOSE OF REVIEW: This review evaluates the current state of artificial intelligence (AI) in head and neck cancer (HNC) rehabilitation services by ma...

Medical large language models and systems in the clinical application of spinal diseases: Current status, challenges, and future prospects.

Large Language Models (LLMs), represented by the Generative Pretrained Transformer (GPT), are profoundly transforming the healthcare sector. Spine med...

Artificial intelligence for microbiology and microbiome research.

Advancements in artificial intelligence (AI) have transformed many scientific fields, with microbiology and microbiome research now experiencing signi...

Vulnerability and short clinical outcomes in patients on the deceased-donor kidney transplant waiting list.

BACKGROUND: With prolonged waiting times for deceased-donor kidney transplantation (DDKT) in Japan, objective data on frailty among wait-listed patien...

Exploration of an interpretable machine learning-based screening manner for low muscle mass among Chinese community-dwelling older adults using routine physical examination information.

BACKGROUND: With the accelerating aging of the global population, muscle health issue occurs commonly as an age-related process in older people. The c...

Quantum-Transport Informed Machine Learning for Identifying Tobacco-Induced Regioisomeric DNA Adducts.

Tobacco smoke contains a complex array of genotoxic carcinogens that form structurally diverse DNA adducts, driving mutagenesis and carcinogenesis. Am...

Young academic psychiatrists in 2050s: future directions across low- and high-income settings.

Academic psychiatrists inhabit two professional identities: clinician and researcher. In some settings they also carry out teaching to a range of staf...

Association of cardiovascular-kidney-metabolic syndrome stages with MASLD prevalence and liver fibrosis severity: evidence from traditional and machine learning approaches.

INTRODUCTION: Cardiovascular-Kidney-Metabolic (CKM) syndrome reflects the convergence of cardiovascular, renal, and metabolic disorders. Metabolic dys...

Neural Vision Restoration in Ophthalmology.

Neural vision restoration is a rapidly advancing discipline at the intersection of neuroscience, bioengineering, and ophthalmology. This review synthe...

Objective Assessment in Clinical Psychological Science: Progress in Wearable Alcohol Biosensors.

Clinical psychology is a discipline reliant on self-reports but uniquely susceptible to specific biases associated therewith. Here we provide a protot...

Advancing Precision Nutrition Through Multimodal Data and Artificial Intelligence.

Interindividual variability in metabolic responses to diets complicates the relationship between nutrition and metabolic health, which highlights the ...

Inflammation at the crossroads of reproduction: SIRI as a prognostic signature of female infertility in hybrid regression-machine learning models.

BACKGROUND: Female infertility is a critical global health concern, with a rising prevalence and significant psychosocial consequences. This study aim...

An end-to-end convolutional neural network for secure image transmission via joint encryption and steganography.

Further attachment of image-based communication speed to sensitive areas must be provided with confidential and safe transmission. Conventional method...