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Precision forensic toxicology: Leveraging Toxicogenomics, multi-omics, and artificial intelligence for next-generation poisoning investigations.

For much of its history, forensic toxicology was built on a core analytical question: what poison or drug is present, and at what concentration? That question still matters, but modern casework increasingly shows that it is no longer sufficient on its own. The field grew from the nineteenth-century chemical toxicology of Mathieu Orfila and the arsenic-detecting Marsh test into a discipline central...

Predictive value of the uric acid to high-density cholesterol ratio (UHR) combined with intact parathyroid hormone for protein-energy wasting after incident hemodialysis: a multicenter study.

Protein-energy wasting (PEW) is common in incident hemodialysis patients and linked to poor outcomes. The uric acid/HDL-cholesterol ratio (UHR) and intact parathyroid hormone (iPTH) relate to metabolic, inflammatory, and nutritional disturbances, but their value for predicting PEW in incident hemodialysis is unclear. This retrospective multicenter study included 863 incident hemodialysis patients....

Mapping the knowledge landscape of planarian regeneration: a century of bibliometric insights.

BACKGROUND: Despite over two centuries of research, the knowledge landscape of planarian regeneration-a pivotal model for stem cell biology and regene...

Protein engineering: Status report.

With this status report, we aim to provide a timely snapshot of the protein engineering field as a broad and rapidly advancing discipline that integra...

Relevance and Implications of Precision Nutrition to Nutrition Education and Behavior Research, Practice, and Policy.

Precision Nutrition (PN) is a rapidly evolving field, yet the implications are unknown for nutrition education and behavior. The objectives of this pe...

Anticipating the Impact of AI on Diet and Exercise Apps: Foresight Study Applying the Futures Wheel.

AI has entered the wellness space through apps and wearables. These technologies can collect real-time data, infer lifestyle patterns, and dynamically...

Tail wagging cats: Veterinary implications of AI-generated video.

BACKGROUND: Generative artificial intelligence (genAI) has the capacity to create realistic and convincing animal videos; however, it must simplify an...

The illusion of competence: Evaluating the clinical reasoning of large language models in pediatric gastroenterology.

OBJECTIVE: To evaluate the diagnostic accuracy and clinical reasoning of three frontier large language models (LLMs) across standardized pediatric gas...

Clinical neuroanatomy teaching at Peking University Health Science Center: Evolution, current practice, and future direction.

Neuroanatomy has been considered one of the most challenging subjects in medical education, often leading to "neurophobia" and discouraging students f...

Next-Generation Food Enzymology: From Metagenomic Discovery to AI-Driven Biocatalyst Design.

Food enzymology is entering a new era driven by the convergence of metagenomics, artificial intelligence, and synthetic biology. While traditional foo...

The Role of Artificial Intelligence and Machine Learning in Predictive Virology: Forecasting, Tracking, and Combating Viral Threats.

The escalating threat of viral pandemics, dramatically illustrated by the COVID-19 crisis, has exposed the critical shortcomings of conventional react...

The Triglyceride Glucose-a Body Shape Index: A Novel Composite Index for Prediction of Periodontitis Risk.

INTRODUCTION AND AIM: Insulin resistance and obesity are significant metabolic risk factors for periodontitis. This study aimed to systematically inve...

Pathway engineering for sustainable biomanufacturing: integrating AI, systems biology, enzyme engineering, and dynamic control.

Sustainable biomanufacturing seeks to replace fossil-fuel-based production with renewable bioeconomies, with microbial cell factories serving as key p...

Future of CT body composition research: Methodological discrepancies and advances.

Body composition research utilizing computed tomography (CT) has increased over the past several decades as researchers use clinically acquired CT for...

State of Medical Education Research in Anesthesiology: Current Landscape and Future Directions-An Initiative of the Anesthesia Research Council.

BACKGROUND: Without strategic intervention to support medical education research in anesthesiology, the training of future anesthesiologists may be co...

State of Medical Education Research in Anesthesiology: Current Landscape and Future Directions-An Initiative of the Anesthesia Research Council.

BACKGROUND: Without strategic intervention to support medical education research in anesthesiology, the training of future anesthesiologists may be co...

Interpretable machine learning models predict cognitive impairment in adults aged 50 and over with diabetes: influence of dietary nutrients.

Introduction: diabetes mellitus increases the risk of cognitive impairment, but the role of dietary nutrients remains unclear. Objectives: to develop ...

Comparative Evaluation of Locally Delivered Aloe vera Gel as an Adjunct to Scaling and Root Planing in Patients With Periodontitis: A Randomized Clinical Trial.

BACKGROUND: Herbal adjuncts have gained increasing interest in nonsurgical periodontal therapy because of their anti-inflammatory, antimicrobial, and ...

Medical Affairs in the Age of Complexity: From Scientific Support to Strategic Enterprise Integrator.

Regulatory acceleration, expanded reliance on real-world evidence (RWE), and increasing integration of artificial intelligence (AI) into healthcare sy...

Frailty burden and symptomatic BPH/LUTS in aging men: evidence from two nationally representative population-based studies.

BACKGROUND: The frailty index (FI) is a well-established marker of biological aging and a widely validated predictor of adverse health outcomes in old...