Parkinson's Disease

Effects of a Soft Robotic Exoskeleton for Gait Training on Clinical Outcomes in Patients With Parkinson Disease: Randomized Controlled Pilot Study.

BACKGROUND: Balance and gait disorders in Parkinson disease (PD) impair motor function and quality o...

A Qualitative Exploration of Ethical Aspects of Using AI in Parkinson Disease: Patient Panel Study.

BACKGROUND: As Parkinson disease (PD) rates increase, so does interest in finding new technological ...

Unveiling the causal pathway of Parkinson's disease dysphonia: A voice causal generative model (VCGM) approach.

BACKGROUND: Although artificial intelligence (AI) models have demonstrated high accuracy in diagnosi...

Cognitive trajectories in early Parkinson's disease: A multimodal MRI study of brain structure and cognitive decline.

Cognitive trajectories in Parkinson's disease (PD) exhibit substantial heterogeneity, ranging from l...

Essence: A benchmarking-validated transformer framework for early diagnosis of Parkinson's disease using cerebrospinal fluid protein biomarkers.

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-...

Frequency-based deep learning to identify subtle postural instability in early, untreated Parkinson's disease.

Despite evidence of early neurodegeneration, postural instability is commonly associated with later ...

Rule-Based Synthesis of Microscopy Images by Diffusion Refinement.

Deep learning methods in medical imaging often suffer from the limited availability of high-quality ...

Using explainable AI to identify disease-relevant and deep brain stimulation treatment-sensitive gait features in Parkinson's disease.

Functional cortical network alterations in Parkinson's disease with wearing-off revealed by resting-state fNIRS and graph theory.

Wearing-off (WO) is a common motor complication in Parkinson's disease (PD), characterized by the re...

AI-based mouse behavior analysis in pathology: A focus on movement disorders.

Quantifying behavior in animal models is essential for understanding neurological disorders, yet tra...

Engineering brain-penetrant PROTACs: Bridging molecular design and CNS delivery.

The drug development for central nervous system (CNS) disorders, particularly neurodegenerative dise...

From Bio-Interface Materials to Neural Integration: The Next-Generation Brain-Machine Interfaces Powered by Hydrogels.

Brain-machine interfaces (BMIs), which serve as revolutionary tools for neural recording, modulation...

Machine learning model based on plasma proteomics for the identification of Parkinson's disease.

Developing reliable biomarkers capable of differentiating Parkinson's disease from other neurologica...

LadderGen: a large-scale generative library of ladder polymers for membrane separations.

Ladder polymers possess exceptional rigidity, microporosity, and thermal stability, yet their explor...

Hierarchical Coarse-to-Fine cGAN for Subtype-Specific Freezing of Gait Signal Generation.

Freezing of gait (FOG), a debilitating symptom of Parkinson's disease, can manifest in three sub-typ...

Neuromodulation-induced normalization of cortical metastable dynamics signatures in Parkinson's disease.

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates motor symptoms in Parkinson...

Use of Machine Learning to Identify Markers of Risk for Fragile X-Associated Tremor/Ataxia Syndrome: A Preliminary Analysis.

OBJECTIVE: The objective of this study was to examine whether machine learning has the capacity to p...

Transformation of Parkinson's care through SMART-PD (Self-Management, Remote monitoring and Timely review for Parkinson's Disease): Care pathway mapping with clinical experts.

Purpose of researchSMaRT-PD is a clinical decision support system (CDSS) for the home-based manageme...

Multi-neurotransmitter synergistically regulated basal ganglia reinforcement learning model.

As a core brain region for motor control and cognitive decision-making, the basal ganglia relies on ...

MRI-Guided High-Intensity Focused Ultrasound in Movement Disorders: Targeting Pathologic Brain Circuits With Precision Imaging, From the AJR Special Series on Critical Anatomy.

MRI-guided high-intensity focused ultrasound (MRgHIFU) has emerged as an alternative to other neurom...

ML-Based Multidomain Speech Biomarkers for Multiclass Parkinson's Severity: An Indian Corpus and Clinically Calibrated Labels.

OBJECTIVE: Speech provides a lightweight window into articulatory and phonatory impairment in Parkin...