Parkinson's Disease

The olfactory bulb reflects structural plasticity within a genetically stable olfactory network

The olfactory bulb (OB), the first central relay of the olfactory pathway, plays a critical role in odor perception and exhibits remarkable structural plasticity shaped by environmental influences. This raises a fundamental question about the extent to which the structure of the OB is genetically determined. While both OB volume and function have been implicated in a range of neurodegenerative and...

Deep neurobehavioral phenotyping uncovers neural fingerprints of locomotor deficits in Parkinson’s disease

Gait deficits present an unresolved therapeutic challenge in Parkinson’s Disease. At the behavioral level, symptoms exhibit heterogeneity, including bradykinesia and hypokinesia during cyclical limb movement, as well as sudden interruptions in the gait sequence, also known as freezing of gait. The neural activities that drive these various deficits remain largely unknown. Here, we investigated the...

Hand Drawing Image based Causal Representation Learning for Robust Parkinson’s Disease Feature Extraction and Detection

Being an irreversible disorder regarding the human motor-system, Parkinson’s Disease(PD) has been a threat to many neurological patients, especially d...

Next generation neural mass model with dopamine modulation mediated by D1-type receptors

Neuromodulation is a complex process in which chemical substances modulate brain activity, allowing its rich repertoire of behaviors. Among these subs...

Fingerprint-Based Explainable Machine Learning for Predicting Blood–Brain Barrier Permeability

Predicting blood–brain barrier (BBB) permeability is essential for early central nervous system (CNS) drug discovery, yet reliable computational scree...

Hierarchical Coarse-to-Fine cGAN for Subtype-Specific Freezing of Gait Signal Generation

Freezing of gait (FOG), a debilitating symptom of Parkinson’s disease, manifests in subtypes as shuffling, trembling, or akinesias, with occurrence an...

Tissue Reassembly with Generative AI

The spatial arrangement of cells is fundamental to their function, but single-cell RNA sequencing loses spatial context by dissociating cells from tis...

Leveraging Deep Learning and MD Simulations to Decipher the Molecular Basis of Attenuated Activity in Glycocin F

The escalating crisis of multi-drug resistant bacteria demand a new generation of antibiotics. Glycocin F (GccF), a potent bacteriocin, is a promising...

Feature-Mask-Based Strategies for Subtype-Specific Freezing of Gait Detection using CNNs

Freezing of gait (FOG), a disabling symptom of Parkinson’s disease, varies in manifestations and motion contexts. Its heterogeneity motivates subtype ...

Neural Underpinnings of Olfactory Dysfunction across Parkinson’s and Alzheimer’s Spectra

Olfactory dysfunction is a frequent yet understudied feature of neurodegenerative spectrum disorders, including Alzheimer’s disease (AD) and Parkinson...

Leveraging Multimodal Large Language Models to Extract Mechanistic Insights from Biomedical Visuals: A Case Study on COVID-19 and Neurodegenerative Diseases

The COVID-19 pandemic has intensified concerns about its long-term neurological impact, with growing evidence linking SARS-CoV-2 infection to neurodeg...

REM sleep predicts reductions in pathophysiological daytime basal ganglia-cortical circuit activity in Parkinson’s disease

Sleep disturbances have been shown to be intimately and bidirectionally related to disease progression across a wide range of neurodegenerative disord...

Cingulate-centered flexible control: physiologic correlates and enhancement by internal capsule stimulation

The flexible deployment of cognitive control is essential for adaptive functioning in dynamic environments given limited cognitive resources. That fle...

Machine Learning Analysis of Cilia-Driven Particle Transport Distinguishes Primary Ciliary Dyskinesia Cilia from Normal Cilia

Primary ciliary dyskinesia (PCD) is a genetic condition that results in dysmotile cilia and abnormal mucociliary clearance. Despite advances in unders...

Comparative Single-Cell Transcriptomics Uncovers Shared and Distinct Molecular Signatures in Cystic Fibrosis and Primary Ciliary Dyskinesia

Cystic Fibrosis (CF) and Primary Ciliary Dyskinesia (PCD) are both inherited respiratory disorders that result in impaired mucociliary clearance, and ...

ProCyon: A multimodal foundation model for protein phenotypes

Characterizing human proteins remains a major challenge: approximately 29% of human proteins lack experimentally validated functions and even well-ann...

Multi-cohort, cross-species urinary proteomics reveals signatures of LRRK2 dysfunction in Parkinson’s disease

Pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson’s disease (PD) and often increase kinase a...

Topological basal ganglia model with dopamine-modulated spike-timing-dependent plasticity reproduces reinforcement learning, discriminatory learning, and neuropsychiatric disorders

The basal ganglia (BG) are central to action selection and reinforcement learning, yet how the topological organization of the BG circuit with dopamin...

Muscle activation prediction in essential tremor through neuromusculoskeletal digital twinning and deep neural networks

Essential tremor (ET) is the most common movement disorder in adults, affecting up to 5% of the population over 65 years of age. Accurately predicting...

Designing Convergent Overlapping Genes with Transformer Encoder Models and Lightweight Structural Proxies

Overlapping genes allow multiple proteins to be encoded from a single DNA sequence, including convergent (antisense; tail-to-tail) orientations across...