Pathology

Mechanisms underlying obesity-malignancy connection: a systematic narrative review.

The association between obesity and cancer risk carries substantial public health ramifications as obesity promotes cancer advancement via many cellular and molecular mechanisms. This study utilizes Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and narrative systematic review guidelines to evaluate 221 research articles selected from an initial collection of 1,288 pub...

Single-cell multimodal analysis reveals tumor microenvironment predictive of treatment response in non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) constitutes over 80% of lung cancer cases and remains a leading cause of cancer-related mortality worldwide. Despite the advent of immune checkpoint inhibitors, their efficacy is limited to 27 to 45% of patients. Identifying likely treatment responders is essential for optimizing healthcare and improving quality of life. We generated multiplex immunofluorescence ...

Ovarian Cancer Screening: Recommendations and Future Prospects.

Ovarian cancer remains a significant cause of mortality among women, largely due to challenges in early detection. Current screening strategies, inclu...

Cutting-edge assays for mirabegron and tadalafil combo therapy for benign prostatic hyperplasia; insilico kinetics approach; multi trait sustainability assessment.

The combination therapy of mirabegron (MIR) and tadalafil (TAD) has gained significant attention in clinical practice for the treatment of Benign Pros...

Towards precision medicine in antiphospholipid syndrome.

Antiphospholipid syndrome is a rare systemic autoimmune disorder with complex pathophysiology and high heterogeneity in clinical presentation and trea...

Enhancing Label-Free Fluorescence Lifetime Imaging for Intraoperative Tumor Margin Delineation in Head and Neck Cancer using Data-Centric AI.

Precise intraoperative delineation of tumor margin is critical for maximizing resection completeness and minimizing recurrence in head and neck cancer...

Liquid Biopsy: The Challenges of a Revolutionary Approach in Oncology.

Liquid biopsy has gained attention in oncology as a non-invasive diagnostic tool, offering valuable insights into tumor biology through the analysis o...

DeepD&Cchl: an AI tool for automated 3D single-cell chloroplast detection, counting, and cell type clustering.

Chloroplast density in cells varies among different types of cells and plants. In current single-cell spatiotemporal analysis, the automatic detection...

Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma.

BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare type of tumor closely associated with asbestos exposure. Increasing evidence shows that hig...

Aging at the Crossroads of Organ Interactions: Implications for the Heart.

Aging processes underlie common chronic cardiometabolic diseases such as heart failure and diabetes. Cross-organ/tissue interactions can accelerate ag...

Characterization and discrimination of periodic nanostructures with scanning-free GEXRF.

As nanostructures in the semiconductor industry become smaller and more complex, non-destructive characterization methods capable of measuring buried ...

Revealing 3D microanatomical structures of unlabeled thick cancer tissues using holotomography and virtual H&E staining.

In histopathology, acquiring subcellular-level three-dimensional (3D) tissue structures efficiently and without damaging the tissues during serial sec...

Imputing single-cell protein abundance in multiplex tissue imaging.

Multiplex tissue imaging enables single-cell spatial proteomics and transcriptomics but remains limited by incomplete molecular profiling, tissue loss...

Combinative protein expression of immediate early genes c-Fos, Arc, and Npas4 along aversive- and reward-related neural networks.

Expression of immediate early genes (IEGs) is critical for memory formation and has been widely used to identify the neural substrate of memory traces...

Diagnostic Methods and Biomarkers in Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD) refers to a chronic inflammatory condition involving the GI tract that includes Crohn's disease (CD) and ulcerative c...

An Ultrasound Image-Based Deep Learning Radiomics Nomogram for Differentiating Between Benign and Malignant Indeterminate Cytology (Bethesda III) Thyroid Nodules: A Retrospective Study.

RATIONALE AND OBJECTIVES: Our objective is to develop and validate a deep learning radiomics nomogram (DLRN) based on preoperative ultrasound images a...

Metabolic reprogramming and immune microenvironment profiling in clear cell renal cell carcinoma: implications for prognosis, targeted therapy, and drug resistance.

Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of kidney cancer, distinguished by intricate interactions between metabolic reprogr...

SLIMBRAIN database: A multimodal image database of in vivo human brains for tumour detection.

Hyperspectral imaging (HSI) and machine learning (ML) have been employed in the medical field for classifying highly infiltrative brain tumours. Altho...

Computer Viewing Model for Classification of Erythrocytes Infected with spp. Applied to Malaria Diagnosis Using Optical Microscope.

Malaria is a disease that can result in a variety of complications. Diagnosis is carried out by an optical microscope and depends on operator experie...

A Complete Transfer Learning-Based Pipeline for Discriminating Between Select Pathogenic Yeasts from Microscopy Photographs.

Pathogenic yeasts are an increasing concern in healthcare, with species like often displaying drug resistance and causing high mortality in immunocom...