Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Intercellular communication in the brain via dendritic nanotubular network.

Recent studies have identified intercellular networks for material exchange by bridge-like nanotubular structures, yet their existence in neurons remains unexplored within the brain. Here, we identified long, thin dendritic filopodia that establish direct dendrite-to-dendrite contacts, forming dendritic nanotubes (DNTs) in mammalian brains. Using super-resolution microscopy, we characterized their...

May 21 2025 40475405

Improving Ovarian Cancer Subtyping with Computer Vision Models on Tiled Histopathological Images.

Ovarian cancer remains one of the most challenging cancers to diagnose due to its non-specific symptoms, lack of reliable screening tests, and the complexity of detecting abnormalities. Accurate subtype classification is crucial for personalised treatment and improved patient outcomes. In this study, we developed a machine learning pipeline fine-tuning pre-trained computer vision models to classif...

May 20 2025 40392413
Development and validation of an artificial intelligence-based pipeline for predicting oral epithelial dysplasia malignant transformation.

BACKGROUND: Oral epithelial dysplasia (OED) is a potentially malignant histopathological diagnosis given to lesions of the oral cavity that are at ris...

May 20 2025 40394272
Histopathology-Based Prostate Cancer Classification Using ResNet: A Comprehensive Deep Learning Analysis.

Prostate cancer is the most prevalent solid tumor in males and one of the most common causes of male mortality. It is the most common type of cancer i...

May 20 2025 40394318
CMImpute: cross-species and tissue imputation of species-level DNA methylation samples across mammalian species.

The large-scale application of the mammalian methylation array has substantially expanded the availability of DNA methylation data in mammalian specie...

May 20 2025 40394556
New Insights into the Diagnosis and Treatment of Hepatocellular Carcinoma.

Hepatocellular carcinoma remains one of the leading contributors to global cancer mortality, frequently stemming from chronic liver conditions, such a...

May 20 2025 40427070
Integrating Artificial Intelligence and Precision Therapeutics for Advancing the Diagnosis and Treatment of Age-Related Macular Degeneration.

Age-related macular degeneration (AMD) is a multifactorial retinal disease influenced by complex molecular mechanisms, including genetic susceptibilit...

May 20 2025 40428167
Sub-phenotypes of pneumonia defined by pulmonary histopathological features.

Establishing sub-phenotypes of pneumonia based on distinct host processes will be a step towards using host-directed therapies (to complement microbe-...

May 20 2025 40475544
Role of VATS-US in identifying and characterizing pulmonary nodules: a narrative review.

The aim of this study was to show the efficacy described in the scientific literature of lung ultrasound (LU) during video-assisted thoracic surgery (...

May 20 2025 40463619
Classification of non-small cell lung cancer by histologic subtype using deep learning in public and private data sets of computed tomography images.

OBJECTIVE: To develop a deep learning system to classify non-small cell lung cancer (NSCLC) by histologic subtype-adenocarcinoma or squamous cell carc...

May 20 2025 40487349
Machine Learning-Based Reward-Driven Tuning of Scanning Probe Microscopy: Toward Fully Automated Microscopy.

Since the dawn of scanning probe microscopy (SPM), tapping or intermittent contact mode has been one of the most widely used imaging modes. Manual opt...

May 19 2025 40387070
Utilizing Deep Learning to Identify Electron-Dense Deposits in Renal Biopsy Electron Microscopy Images.

INTRODUCTION: Electron microscopy (EM) is a crucial technique for identifying and distinguishing the specific location of deposits within glomeruli. M...

May 19 2025 40388893
Preoperative DBT-based radiomics for predicting axillary lymph node metastasis in breast cancer: a multi-center study.

BACKGROUND: In the prognosis of breast cancer, the status of axillary lymph nodes (ALN) is critically important. While traditional axillary lymph node...

May 19 2025 40389828
Diagnosis of early idiopathic pulmonary fibrosis: current status and future perspective.

The standard approach to diagnosing idiopathic pulmonary fibrosis (IPF) includes identifying the usual interstitial pneumonia (UIP) pattern via high r...

May 19 2025 40390073
Mpox diagnosis at POC.

The increasing number of Monkeypox (Mpox) cases in non-endemic countries resulted in the WHO declaring a public health emergency of international conc...

May 19 2025 40393854
Integration of structural study and machine learning to elucidate the RNA-SFs interaction atlas in eukaryotic cells.

Alternative splicing (AS) occupies a central position in plant growth and development, stress response, and animal growth and disease processes. Mutat...

May 19 2025 40398644
Layer-Specific Colocalization of Microglia with Amyloid Plaques in the Middle Temporal Gyrus Predicts Cognitive Decline in Alzheimer's Disease.

Alzheimer's disease (AD), the most common form of dementia, is marked by cognitive decline and amyloid-beta (Aβ) plaque deposition in the brain. Micro...

May 19 2025 40423635
Study on Liver Sinusoidal Endothelial Cell Fenestrations Based on Cellular Omics-Structure Integration Technology and Its Application in Metabolic Diseases.

This study developed a new Cellular Omics-Structural Integration (COSI) technology platform to address the limitation of traditional technologies in s...

May 19 2025 40475559
Investigation of novel carboxymethyl chitosan-based bioinks for 3D bioprinting of neural tissues.

The formulation of bioinks is critical for successful 3D bioprinting. It influences printability, stability, and cell behavior. This study focused on ...

May 19 2025 40345226
Transforming Gastrointestinal Diagnosis with Molecular Endoscopy: Challenges and Opportunities.

Molecular endoscopy represents a transformative advance in the detection, diagnosis, and management of gastrointestinal diseases, addressing the criti...

May 18 2025 40429975
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