Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Deep Learning-driven Microfluidic-SERS to Characterize the Heterogeneity in Exosomes for Classifying Non-Small Cell Lung Cancer Subtypes.

Lung cancer exhibits strong heterogeneity, and its early diagnosis and precise subtyping are of great importance, as they can increase the ability to deliver personalized medicines by tailoring therapy regimens. Tissue biopsy, albeit the gold standard, is invasive, costly and provides limited information about the tumor and its molecular landscape. Exosomes, as promising biomarkers for lung cancer...

Apr 1 2025 40167999

Artificial intelligence predicts multiclass molecular signatures and subtypes directly from breast cancer histology: a multicenter retrospective study.

Detection of biomarkers of breast cancer incurs additional costs and tissue burden. We propose a deep learning-based algorithm (BBMIL) to predict classical biomarkers, immunotherapy-associated gene signatures, and prognosis-associated subtypes directly from hematoxylin and eosin stained histopathology images. BBMIL showed the best performance among comparative algorithms on the prediction of class...

Apr 1 2025 39764584
Will artificial intelligence (AI) replace cytopathologists: a scoping review of current applications and evidence of A.I. in urine cytology.

PURPOSE: Urine cytology, while valuable in facilitating the detection and surveillance of bladder cancer, has notable limitations. The application of ...

Apr 1 2025 40167778
Improved gated recurrent unit-based osteosarcoma prediction on histology images: a meta-heuristic-oriented optimization concept.

The major prevalent primary bone cancer is osteosarcoma. Preoperative chemotherapy is accompanied by resection as part of the normal course of treatme...

Apr 1 2025 40169634
A hybrid parallel convolutional spiking neural network for enhanced skin cancer detection.

The most widespread kind of cancer, affecting millions of lives is skin cancer. When the condition of illness worsens, the chance of survival is reduc...

Apr 1 2025 40169652
[Research progress of effect mechanism of acupotomy for knee osteoarthritis].

Acupotomy therapy demonstrates the definite clinical efficacy on knee osteoarthritis (KOA). After reviewing systematically the mechanism studies on ac...

Mar 31 2025 40518794
Digital quantification of Ki67 and PRAME in challenging melanocytic lesions - A novel diagnostic tool.

The interpretation of immunohistochemical markers in melanocytic lesions possesses difficulties due to expression in non-melanocytic cells and the tim...

Mar 31 2025 40209567
Computer-assisted diagnosis to improve diagnostic pathology: A review.

With an increasing demand for accuracy and efficiency in diagnostic pathology, computer-assisted diagnosis (CAD) emerges as a prominent and transforma...

Mar 31 2025 40162930
Automated detection of metastatic lymph nodes in head and neck malignant tumors on high - resolution MRI images using an improved convolutional neural network.

PURPOSE: To develop an AI-based diagnostic model for assessing cervical lymph nodes in head and neck malignant tumors using MRI, enabling non-invasive...

Mar 30 2025 40220628
A deep-learning algorithm (AIFORIA) for classification of hematopoietic cells in bone marrow aspirate smears based on nine cell classes-a feasible approach for routine screening?

Bone marrow cytology plays a key role for the diagnosis and classification of hematological disease and is often the first step in the acute setting o...

Mar 29 2025 40156646
Advancements in Circulating Tumor Cell Detection for Early Cancer Diagnosis: An Integration of Machine Learning Algorithms with Microfluidic Technologies.

Circulating tumor cells (CTCs) are vital indicators of metastasis and provide a non-invasive method for early cancer diagnosis, prognosis, and therape...

Mar 29 2025 40277534
Machine learning-guided Orbitrap-HRAMS-based metabolomic fingerprinting for geographical origin, variety and tissue specific authentication, and adulteration detection of turmeric and ashwagandha.

The increasing global demand for herbs and spices in food and nutraceutical industries highlights their key functional benefits, including antioxidant...

Mar 28 2025 40187315
Exploring the Incremental Value of Aorta Enhancement Normalization Method in Evaluating Renal Cell Carcinoma Histological Subtypes: A Multi-center Large Cohort Study.

RATIONALE AND OBJECTIVES: The classification of renal cell carcinoma (RCC) histological subtypes plays a crucial role in clinical diagnosis. However, ...

Mar 28 2025 40157848
ULST: U-shaped LeWin Spectral Transformer for virtual staining of pathological sections.

At present, pathological section staining faces several challenges, including complex sample preparation and stringent infrastructure requirements. Vi...

Mar 28 2025 40164031
Explainable machine learning to compare the overall survival status between patients receiving mastectomy and breast conserving surgeries.

The most prevalent malignancy among women is breast cancer; hence, treatment approaches are needed in consideration of tumor characteristics and disea...

Mar 28 2025 40155719
Identification of testicular cancer with T2-weighted MRI-based radiomics and automatic machine learning.

BACKGROUND: Distinguishing between benign and malignant testicular lesions on clinical magnetic resonance imaging (MRI) is crucial for guiding treatme...

Mar 28 2025 40155850
Bibliometric and LDA analysis of acute rejection in liver transplantation: Emerging trends, immunotherapy challenges, and the role of artificial intelligence.

With the rising demand for liver transplantation (LT), research on acute rejection (AR) has become increasingly diverse, yet no consensus has been rea...

Mar 28 2025 40152403
ALADDIN: A Machine Learning Approach to Enhance the Prediction of Significant Fibrosis or Higher in Metabolic Dysfunction-Associated Steatotic Liver Disease.

INTRODUCTION: The recent US Food and Drug Administration approval of resmetirom for treating metabolic dysfunction-associated steatohepatitis in patie...

Mar 27 2025 40146016
Imaging and spatially resolved mass spectrometry applications in nephrology.

The application of spatially resolved mass spectrometry (MS) and MS imaging approaches for studying biomolecular processes in the kidney is rapidly gr...

Mar 27 2025 40148534
The growing field of liquid biopsy and its Snowball effect on reshaping cancer management.

Liquid biopsy (LB) has emerged as a transformative tool in oncology, providing a minimally invasive approach for tumor detection, molecular characteri...

Mar 27 2025 40255897
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