Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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SIGNAL: A Scalable, Real-World Model for Rapid Intraoperative Molecular Classification of Gliomas Using Stimulated Raman Histology

Background: Previous machine learning models to intraoperatively predict the molecular status of gli...

RNA-FM: Flow-Matching Generative Model for Genome-wide RNA-Seq Prediction

Histopathology whole-slide images (WSIs) are routinely acquired in clinical practice and contain ric...

M3Net: A Macro-to-Meso-to-Micro Clinical-inspired Hierarchical 3D Network for Pulmonary Nodule Classification

The accurate classification of benign and malignant pulmonary nodules in CT scans is critical for ea...

Are Compact Rationales Free? Measuring Tile Selection Headroom in Frozen WSI-MIL

Whole-slide image (WSI) multiple instance learning (MIL) classifiers can achieve strong slide-level ...

A CBF-SA module links wound-induced evaporative cooling to tissue repair in plants

Repairing damaged tissues is essential for the survival of all organisms. In plants, tissue injury r...

Serum proteomic atlas reveals distinct molecular signatures of lupus nephritis activity, chronicity, and treatment response

Lupus nephritis (LN), a severe manifestation of systemic lupus erythematosus (SLE), features heterog...

Machine Learning Analysis to Define Cell Lineage in Leiomyosarcoma

Introduction Cellular differentiation and lineage commitment are known to be associated with differe...

3DBrainOne: an integrated end-to-end platform for 3D histological analysis of whole mouse brains

Three-dimensional (3D) whole-organ imaging and analysis at cellular resolution (termed 3D histology)...

InterScale reveals multi-scale cellular interaction programs in spatial transcriptomics

Tissue homeostasis and disease emerge from cell-cell interactions operating across spatial scales: f...

Cortical reconstruction and anatomical parcellation of high-resolution multi-modal postmortem ex vivo MRI of the human infant brain

High-resolution postmortem (ex vivo) magnetic resonance imaging enables detailed examination of brai...

BRIDGE: A Multi-organ Histo-ST Foundation Model Enables Virtual Spatial Transcriptomics for Enhanced Few-shot Cancer Diagnosis

Recent studies have explored generating virtual spatial transcriptomics (ST) profiles from histologi...

Conserved neuroectodermal aging encodes primate health and longevity

Neuroectoderm-derived tissues are highly metabolically active and exhibit minimal regenerative turno...

Spatial remodeling of the urothelial carcinoma tumor microenvironment shapes response to neoadjuvant atezolizumab

The ABACUS study was a single arm, phase II trial evaluating neoadjuvant atezolizumab in operable ur...

Enhancing dengue diagnosis and surveillance by integrating machine learning technologies with the NS1 rapid test kit

Background. Dengue has been a major health threat globally in recent years. In particular, dengue in...

Predicting bladder cancer molecular subtypes linked to bacillus Calmette-Guerin response from histology images using deep learning

Background and objective: High-risk non-muscle-invasive bladder cancer (HR-NMIBC) is treated with tr...

Uncertainty-aware localization microscopy by variational diffusion

Fast extraction of physically relevant information from images using deep neural networks has led to...

AniMatrix: An Anime Video Generation Model that Thinks in Art, Not Physics

Video generation models internalize physical realism as their prior. Anime deliberately violates phy...

Enhanced 3D Brain Tumor Segmentation Using Assorted Precision Training

A brain tumor is a medical disorder faced by individuals of all demographics. Medically, it is descr...

TRACED: In vivo imaging of extracellular intrinsic diffusivity, tortuosity, cell size distribution and cell density in human glioma patients

The lack of analytical models describing diffusion time dependence at intermediate time scales in co...

Visual Latents Know More Than They Say: Unsilencing Latent Reasoning in MLLMs

Continuous latent-space reasoning offers a compact alternative to textual chain-of-thought for multi...

Virtual Scanning for NSCLC Histology: Investigating the Discriminatory Power of Synthetic PET

Accurate histological differentiation between adenocarcinoma (ADC) and squamous cell carcinoma (SCC)...

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