Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Accurate diagnosis of non-small cell and small cell lung cancer by using machine learning models trained with physical science features extracted from pathological images.

BACKGROUND: Accurate differentiation between non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) is crucial for optimising treatment strategies and improving patient outcomes in lung cancer management. Early and precise classification supports tailored therapeutic decisions and enhances prognosis prediction. PURPOSE: This study develops a novel method to use machine learning model...

Apr 11 2026 41964375

Hybrid physics-machine learning models for quantitative electron diffraction refinements.

High accuracy electron microscopy simulations required for quantitative crystal structure refinements face a fundamental challenge: while physical interactions are well-described theoretically, real-world experimental effects are challenging to model analytically. To address this gap, we present a hybrid physics-machine learning framework that integrates differentiable physical simulations with ne...

Apr 11 2026 41965331
Pathology-Anchored Transcranial Sonography: A Cascaded Super-Resolution Deep Learning System for Early-Stage Parkinson's Disease Grading.

Delayed diagnosis of Parkinson's disease (PD) due to undetectable early pathological changes remains a major clinical challenge limiting effective tre...

Apr 11 2026 41965365
Computed tomography in ARDS, from morphological insights to AI-powered multi-modal analysis: a narrative review.

BACKGROUND: Acute respiratory distress syndrome (ARDS) is a critical clinical condition characterized by acute respiratory failure and high mortality....

Apr 11 2026 41965719
Integrated machine learning and experimental validation reveal S6K2 as a key target of 6PPD-quinone in bladder cancer.

Tire and Road Wear Particles (TRWP) are pervasive environmental contaminants, yet the molecular mechanisms linking their toxic derivative, 6PPD-quinon...

Apr 10 2026 41966021
AI-driven fungicide design: From target identification to field application.

Plant pathogenic fungi severely threaten global agriculture, causing substantial yield losses in staple crops and endangering food safety through myco...

Apr 10 2026 41966053
Regulatory B cells and SIVA1-LAG3 immune suppression predict poor prognosis in prostate cancer.

Prostate cancer (PCa) is among the most prevalent malignancies affecting men globally. The immunosuppressive characteristics of the tumor microenviron...

Apr 10 2026 41960835
Artificial Intelligence in Asthma: From Diagnosis to Management.

Artificial intelligence (AI) offers new opportunities to improve asthma management across the care process. This review synthesizes evidence on AI app...

Apr 10 2026 41960858
Challenges and Controversies in the Diagnosis and Management of Thymic Epithelial Tumors from the Thymic Tumor Subcommittee of the International Association for the Study of Lung Cancer Rare Tumors Committee.

Thymic epithelial tumors (TETs), comprising thymomas, thymic carcinomas, and thymic neuroendocrine neoplasms, are rare prevascular (anterior) mediasti...

Apr 10 2026 41961041
Ultrasound Radiomics for Hashimoto's Thyroiditis: State of the Art and Future Perspectives.

Ultrasound radiomics is gradually emerging as a powerful tool for improving the diagnosis and management of Hashimoto's thyroiditis (HT), effectively ...

Apr 10 2026 41963245
Deepath-SCC: a deep learning model for accurate tissue origin identification in squamous cell carcinoma.

Squamous cell carcinoma (SCC) is a common malignancy that arises in diverse organs and often exhibits overlapping histological and immunophenotypic fe...

Apr 10 2026 41963625
Clinical Translatable and Transparency of Neural Network for Blood-Based Personalized Cancer Risk.

OBJECTIVE: To support cancer screening and identify precancerous conditions, such as atypical hyperplasia, to improve cure rates and reduce mortality,...

Apr 9 2026 42170495
Regulatory risk loci link disrupted androgen response to the pathophysiology of polycystic ovary syndrome.

A major challenge in deciphering the complex genetic landscape of polycystic ovary syndrome (PCOS) lies in the limited understanding of how susceptibi...

Apr 9 2026 41994484
Classification of biliary strictures using real-time cholangioscopy artificial intelligence: the SMART-AI trial.

BACKGROUND: Sampling techniques have poor accuracy for classifying biliary strictures as benign or malignant. Previously, a cholangioscopy artificial ...

Apr 9 2026 41966465
Comprehensive Assessment of Artificial Intelligence as a Stand-alone tool for Cervical Cancer Screening Using a 50% Negative Cutoff Value.

PURPOSE: An emerging application of artificial intelligence (AI) in cervical cytology is its use as an independent screener for triaging cases that do...

Apr 9 2026 41966523
Vocal Age Gap as a Noninvasive Biomarker for Early Detection of Laryngeal Cancer Using Deep Learning.

OBJECTIVES: Early vocal changes such as hoarseness or voice fatigue are common and often attributed to normal aging or benign conditions, which can de...

Apr 9 2026 41963165
Deep learning-driven recognition of panoramic tumor microenvironment features in H&E sections and its application.

The tumor microenvironment (TME), composed of tumor cells together with stromal cells, immune cells, vascular networks, and other components, constitu...

Apr 9 2026 41956540
Identification and experimental validation of aging-related biomarkers in intervertebral disc degeneration.

Intervertebral disc degeneration (IDD) is a prevalent disease with an increasing incidence, and aging is a key risk factor for its progression. Theref...

Apr 9 2026 41957266
Artificial intelligence in clinical oncology: Multimodal integration and translational development.

Artificial intelligence (AI) is rapidly reshaping clinical oncology, as cancer care increasingly relies on integrating heterogeneous data streams span...

Apr 8 2026 41962624
Integration of advanced ultrasound techniques, radiomics, and artificial intelligence for improved diagnosis of cystic breast lesions.

Cystic breast lesions are commonly encountered on breast ultrasound, encompassing a spectrum from simple benign cysts to complex mixed solid and cysti...

Apr 8 2026 41966528
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