Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Preliminary machine-learning model with clinical, US, and CEUS features for the diagnosis of thyroid follicular-patterned lesions.

BACKGROUND: Though follicular thyroid carcinoma can be confirmed postoperatively by the histological findings of capsular or vascular invasion, preoperative diagnosis of follicular-patterned lesions has long been a diagnostic challenge. This study seeks to establish a machine-learning (ML) model based on clinical, US, and CEUS features for the differential diagnosis of thyroid follicular-patterned...

May 19 2026 42157115

Habitat analysis and other AI technologies for Ki-67 prediction in hepatocellular carcinoma: a multi-center study.

OBJECTIVES: To develop various artificial intelligence (AI) models including radiomics, deep transfer learning (DTL) and habitat analysis models, as well as a combined model, for the preoperative noninvasive prediction of Ki-67 expression in hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A retrospective analysis was performed on 433 patients with pathologically confirmed HCC from two insti...

May 19 2026 42157135
Applications of bioimpedance measurement in clinical and allied fields: a comprehensive review.

BACKGROUND: Accurate and timely disease detection is essential in modern healthcare. Conventional imaging methods such as computed tomography (CT), ma...

May 19 2026 42157227
Application of Health Examination in Early Screening of Tumors.

Early detection of tumors constitutes a cornerstone of cancer prevention and control. Medical assessments alongside emerging screening modalities prov...

May 19 2026 42162848
Pre-analytical standardization and multi-biofluid harmonization for liquid biopsy biomarkers in lung cancer: From discovery to clinical laboratory implementation.

Lung cancer remains the leading cause of cancer-related mortality worldwide, with early detection being critical for improving survival outcomes. Liqu...

May 19 2026 42162904
Evaluation and enhancement of the prognostic ability of the eighth edition of TNM staging in cutaneous malignant melanoma: a population-based study, using machine learning, of 111 871 patients.

BACKGROUND: Melanoma is the fifth most common cancer in the USA and the UK, with global incidence on the rise. The TNM staging system guides treatment...

May 19 2026 41527920
DNA methylation biomarkers-based pan-cancer classifier: predictive modeling for cancer classification.

BACKGROUND: Machine-learning (ML) driven molecular diagnostics based on omics data has a potential to revolutionize personalized medicine. However, im...

May 19 2026 42152108
The ancient trading hubs of modern science: Bridging the divide between microscopists and data scientists.

Biomedical imaging is increasingly defined by a paradox: advances in microscopy now enable the routine generation of extraordinarily rich, high-dimens...

May 19 2026 42153235
Augmenting prion surveillance by immunohistochemistry using artificial intelligence-based image analysis.

Chronic wasting disease (CWD) and scrapie are transmissible spongiform encephalopathy diseases caused by prions, infectious forms of the prion protein...

May 19 2026 42153288
Spatially Sussing Out the TME, No Tissue Needed.

Through machine learning, researchers have uncovered distinct spatial ecotypes in the tumor microenvironment that are broadly conserved across multipl...

May 19 2026 42153402
Novel biomarkers driving treatment selection in metastatic castration-sensitive prostate cancer: fundamentals of personalized clinical decision making.

INTRODUCTION: Prostate cancer is well known to be androgen-dependent, with growth directly relying on the androgen receptor signaling pathway. In fact...

May 19 2026 42153555
APTw CEST MRI in therapy-naive IDH-wildtype glioblastoma: insights into tumor heterogeneity and molecular subtypes.

PURPOSE: Advanced MRI techniques may provide non-invasive insight into the molecular heterogeneity of glioblastoma. Amide proton transfer-weighted (AP...

May 19 2026 42154346
Detection of Posttraumatic Stress Disorder With Rest-Activity Data: Machine Learning Approach Using Wearable and Self-Report Data.

BACKGROUND: Growing evidence suggests that disruptions in rest-activity rhythms may serve as relevant markers of posttraumatic stress disorder (PTSD)....

May 19 2026 42155096
Microcomputed tomography analysis of marginal adaptation and internal fit of zirconia frameworks with direct-to-abutment connections using a deep learning artificial intelligence model.

STATEMENT OF PROBLEM: Despite the increased use of direct-to-abutment connections for implant-supported fixed complete dental prostheses (ISFCDPs), li...

May 19 2026 42156249
A deep learning system for non-invasive breast cancer diagnosis with multimodal data.

Early and accurate diagnosis of breast cancer is critical for minimizing needle biopsies and enhancing patient outcomes and requires effective integra...

May 19 2026 42157015
Rapid slide-level assessment of glomerular yield using virtual staining of unstained renal biopsy sections.

BACKGROUND: Renal biopsy remains the gold standard for the diagnosis of kidney diseases, and specimen adequacy is essential for reliable histopatholog...

May 19 2026 42157065
From histology to spatial transcriptomics: establishing a lightweight single-patch baseline.

Predicting spatial gene expression from hematoxylin and eosin (H&E)-stained histological images is a central challenge in the field of computational p...

May 18 2026 42151778
The evolving PI-RADS paradigm.

Prostate MRI is central to the diagnostic pathway for prostate cancer (PCa), reducing unnecessary biopsies, improving the detection of clinically sign...

May 18 2026 42152154
Multimodal Artificial Intelligence for Early Detection and Precision Management of Inflammatory and Infiltrative Cardiomyopathies.

BACKGROUND: Inflammatory and infiltrative cardiomyopathies, including cardiac sarcoidosis, transthyretin amyloidosis, and autoimmune myocarditis, are ...

May 18 2026 42155787
The Emergence Clone concept. Optimizing the implant emergence profile using artificial segmentation.

A correct emergence profile is fundamental for achieving a natural result to transition from an implant with a circular neck to a cervical area that r...

May 18 2026 42145242
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