Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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SpiderMass ambient mass spectrometry and multimodal machine learning enable ex vivo ovarian cancer typing and exploratory immunoscoring.

Complete cytoreductive surgery remains one of the strongest determinants of outcome in ovarian cancer, yet surgeons still lack rapid tissue-assessment tools that can be repeated throughout an operation. Here we evaluated whether SpiderMass ambient mass spectrometry, combined with machine-learning models, could support ex vivo ovarian tissue typing and exploratory immune microenvironment mapping. A...

Jul 8 2026 42419565

Radiomics Models as Tools for Predicting Genetic Mutations in Colorectal Cancer: A Systematic Review and Meta-Analysis.

BACKGROUND: The evaluation of genetic mutations is crucial for personalized therapy in colorectal cancer (CRC), but the invasive tissue biopsy is subject to sampling bias and other complications. Radiomics has emerged as a non-invasive tool to predict these mutations from standard medical images. In this systematic review and meta-analysis, we aimed to evaluate the diagnostic accuracy and methodol...

Jul 8 2026 42420571
Anatomically Localized Detection of Six Acute Abdominal Emergencies on CT Using Multi-window Deep Learning: Development and Validation.

The purpose of this study is to develop and retrospectively validate a deep learning system for the classification and anatomically interpretable loca...

Jul 8 2026 42420647
Data-scarce transfer learning fusion for positron emission tomography and computed tomography guided lung biopsy.

OBJECTIVES: We developed a transfer learning-based multimodal fusion deep learning model integrating positron emission tomography/computed tomography ...

Jul 8 2026 42412121
VasSurDetect: An AI-based Chatbot for Rapid, Photo-based Feedback in Microsurgical Suturing Training.

BACKGROUND: Microsurgical suturing training requires precise, repeated feedback, but faculty feedback is often delayed, subjective, and limited by ava...

Jul 8 2026 42422242
AI-Powered Discovery of Rosmarinic Acid as a Novel Ferroptosis Inhibitor for Ulcerative Colitis via Targeting the ALOX15-VDAC1 Axis.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited mechanism-based therapies, and ferroptosis-an iron-dependent lipid peroxi...

Jul 8 2026 42422585
Integrative analyses reveal the evolution of the Old World Swallowtail in the Palearctic.

Based on a dataset of 585 samples originating from across the Palearctic region and four genes (COI, CAD, Ca-ATPase, and 28S) for a subset of these sa...

Jul 8 2026 42418432
Multimodal imaging to analyze the biomechanical properties of kidney tumors, evaluating feasibility, inter-modality correspondence, and diagnostic value (UroCCR-115).

INTRODUCTION: Assessment of renal tissue and renal tumor stiffness may provide complementary information for tissue characterization; however, convent...

Jul 8 2026 42418537
Bioactive Peptides for Oral Diseases: Biomaterial-Assisted Therapeutics and Translational Applications.

Dental caries, periodontitis, oral mucosal inflammation, peri-implant infections, and oral tissue defects remain major clinical burdens. Conventional ...

Jul 7 2026 42411007
Cracking the code of heatstroke: new insights into diagnosis and pathological mechanisms.

As global temperatures continue to rise, the incidence and mortality rates of heatstroke (HS) have significantly increased. However, the current foren...

Jul 7 2026 42412186
HyCANet: a hybrid convolutional-attention network with cross-attention fusion for lung cancer histopathological classification.

Histopathology interpretation of lung cancer involves careful examination of tissue morphology, especially differentiating benign lung tissue, adenoca...

Jul 7 2026 42414443
An Interpretable AI System for Oral Leukoplakia Progression: From Early Screening to Lesion Delineation.

Oral potentially malignant disorders (OPMDs), particularly leukoplakia, represent critical precursors to oral cancer requiring systematic monitoring. ...

Jul 7 2026 42414555
Mantle cell lymphoma artificial intelligence prognostic index using hematoxylin and eosin histology.

The clinical course of Mantle Cell Lymphoma (MCL) varies between individual patients. Early detection of risk is crucial to assign MCL patients to nov...

Jul 7 2026 42414604
CODAvision: best practices and a user-friendly interface for rapid, customizable segmentation of medical images.

Image-based machine learning tools are powerful resources for analyzing medical images, with deep learning-based semantic segmentation commonly utiliz...

Jul 7 2026 42414617
Comparative outcomes of proton and photon therapy in the management of malignant peripheral nerve sheath tumors.

BACKGROUND: Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive sarcomas often arising in the spine, characterized by high metastatic pot...

Jul 7 2026 42414660
A Systematic Review and Meta-analysis of Two-Dimensional Breast Ultrasound Radiomics: Implications for Lesion Characterization and Diagnostic Accuracy.

Radiomics applied to two-dimensional breast ultrasound has emerged as a potential noninvasive approach for differentiating benign from malignant breas...

Jul 7 2026 42414707
Deep Learning-Based Automated Reports for Breast Density Assessment in Mammography Images.

Breast density is a key factor in mammographic screening, as high-density tissue increases cancer risk and can obscure lesions, reducing diagnostic se...

Jul 7 2026 42414711
Domain-Specific Transfer Learning for Gastric Cancer Tissue Classification.

Gastric cancer is the fifth most diagnosed cancer worldwide and is the fifth most deadly. An essential part of the diagnosis and prognosis of cancer i...

Jul 7 2026 42414712
From Gram Stain to Decision Support: Performance of Multimodal Large Language Models in Blood Culture Microscopy.

Multimodal large language models (LLMs) offer significant potential for image-based diagnostics, yet their reliability in routine clinical microbiolog...

Jul 7 2026 42414723
Pilot feasibility study of deep learning-based detection of malignant liver lesions in intraoperative ultrasound imaging.

BACKGROUND: Intraoperative ultrasound plays a central role in hepatobiliary surgery for the detection of liver lesions, but image interpretation is ch...

Jul 7 2026 42414769
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