Peptic Ulcer Disease

Xiao Zhen Fang mitigates cutaneous toxicity by inhibiting PANoptosis: Insights from untargeted metabolomics and transcriptomics.

BACKGROUND: Epidermal growth factor receptor (EGFR) inhibitors and other targeted therapies frequently cause cutaneous toxicities, impairing patient quality of life and treatment adherence. This study investigated the molecular mechanisms underlying the protective effects of Xiao Zhen Fang (XZF), a traditional Chinese medicine formula, against EGFR inhibitor-induced dermatotoxicity. METHODS: An er...

Predictive performance of CT-based artificial intelligence for predicting variceal bleeding in portal hypertension: a systematic review and meta-analysis.

OBJECTIVES: To systematically evaluate the predictive accuracy of computed tomography (CT)-based artificial intelligence (AI) for predicting variceal bleeding (VB) in patients with portal hypertension, and to assess their potential utility as an opportunistic screening tool alongside Baveno VII criteria. METHODS: We searched PubMed, Embase, Web of Science, and Cochrane until December 16, 2025, for...

Postangiography Prediction of Renal Replacement Therapy in Acute Myocardial Infarction-Related Cardiogenic Shock: Least Absolute Shrinkage and Selection Operator Nomogram Development and Validation.

BACKGROUND: Acute kidney injury critically impacts outcomes in cardiogenic shock secondary to acute myocardial infarction (CS-AMI). Acute kidney injur...

Application of Health Examination in Early Screening of Tumors.

Early detection of tumors constitutes a cornerstone of cancer prevention and control. Medical assessments alongside emerging screening modalities prov...

An interpretable machine learning model integrating [18F]FDG PET/CT radiomics and clinical features for predicting perforation following chemotherapy in gastrointestinal lymphoma: a multicenter study.

BACKGROUND: Perforation following chemotherapy in gastrointestinal lymphoma (PFCGL) is a rare but severe and life-threatening complication. Early pre-...

Correspondence on 'Evaluation of the impact of NOAC underdosing and exploration of bleeding risk factors in elderly patients with atrial fibrillation: artificial intelligence-based approach' by Protzenko et al.

Predictors of the Efficacy of Focused Ultrasound for Moderate-to-Severe Persistent Allergic Rhinitis: A Retrospective Cohort Study.

BACKGROUND: Focused ultrasound (FUS) has achieved favorable results in the treatment of allergic rhinitis (AR). However, some patients still have poor...

PythiaStudio: a one-stop protein engineering platform powered by Pythia model suite.

Predicting how mutations affect protein stability and protein-protein binding affinity is crucial for protein engineering and drug development. Althou...

Integrative bioinformatics and machine learning reveal an association of LTF and MMP8 with systemic inflammation and lung injury.

BACKGROUND: Acute lung injury and its severe form, acute respiratory distress syndrome (ARDS), represent life-threatening conditions with high mortali...

Machine learning-driven identification of circulating biomarkers and therapeutic compounds for diabetic retinopathy.

BACKGROUND: Diabetic retinopathy (DR) is a major cause of severe visual impairment, where early diagnosis and intervention are crucial to prevent irre...

Shaping the future of postoperative recurrence in Crohn's disease: personalised approaches with AI-enabled imaging and multi-omics.

Postoperative recurrence (POR) is a major challenge in the long-term management of Crohn's disease (CD), affecting up to 70% of patients within the fi...

Molecular Functions and Drug Prediction of MMP1 and TGFBR2 in Nasopharyngeal Carcinoma.

BACKGROUND: Nasopharyngeal carcinoma (NPC) is partially driven by epithelial-mesenchymal transition (EMT). We identified potential EMT-related biomark...

Molecular mechanisms linking cadmium chloride exposure to ankylosing spondylitis: an integrative network-based study.

Chronic cadmium chloride (CC) exposure is associated with diverse toxicological outcomes, yet its potential role in the pathogenesis of ankylosing spo...

An artificial intelligence classifier as a screening tool to rule out otitis media in children.

OBJECTIVE: Acute otitis media is the most common bacterial infection among children and a significant global health burden. Despite its high incidence...

GATA3 mediates the cardioprotective effect of hydroxysafflor yellow a against septic cardiomyopathy: insights from integrated machine learning, WGCNA, and experimental validation.

UNLABELLED: Sepsis-induced cardiomyopathy represents a life-threatening complication arising from severe sepsis and septic shock. Hydroxysafflor yello...

Artificial intelligence-driven rational design and optimization of a potent terpenoid-derived PCSK9 inhibitor.

Hypercholesterolemia is a pivotal risk factor for cardiovascular diseases, and its effective management is critical to reducing cardiovascular event i...

Development of Models for Predicting the 7-Month Risk of Venous Thromboembolism and Clinically Relevant Bleeding in Ambulatory Patients with Cancer: Analysis from the AVERT Trial.

BACKGROUND: Patients with cancer are at elevated risk of venous thromboembolism (VTE). While primary thromboprophylaxis reduces VTE incidence, it also...

Generative chromoendoscopy for gastric neoplasms: A multicenter prospective study.

BACKGROUND AND STUDY AIMS: Generative indigo carmine chromoendoscopy (generative chromoendoscopy), produced using deep learning-based synthetic image ...

Machine learning-based transcriptomic analysis of differentially expressed genes in the epithelium and stroma of keratoconus.

BACKGROUND: This study was conducted to delineate layer-specific transcriptomic alterations in the keratoconus (KC) epithelium and stroma and to ident...

Thrombosis at the crossroads of inflammation, coagulation, and vascular biology: Recent advances and emerging therapeutic strategies.

Thrombosis is a multifaceted pathological process involving intravascular clot formation that drives a range of cardiovascular and cerebrovascular dis...