Peripheral Artery Disease

Lumbar spinal stenosis: current concept of management.

Lumbar spinal stenosis (LSS) is a common degenerative spinal condition where spinal canal narrowing causes symptoms such as neurogenic claudication, radiculopathy, and lower back pain. While non-operative and surgical approaches yield similar long-term outcomes, surgical intervention-particularly decompression-can provide earlier symptom relief, functional recovery, and fall prevention in selected...

Type 2 Diabetes Mellitus Remission, Dream or Reality? A Narrative Review of Current Evidence and Integrated Care Strategies.

Type 2 diabetes mellitus (T2DM) is a global health priority, with an estimated 629 million people projected to be affected by the year 2045. T2DM significantly increases the risk of atherosclerotic cardiovascular disease and other complications. Hyperglycaemia imprints early molecular and cellular changes, often termed "metabolic memory", predisposing individuals to long-term microvascular and mac...

Long-term prognostic value of the CT-derived fractional flow reserve combined with atherosclerotic burden in patients with non-obstructive coronary artery disease.

OBJECTIVES: The long-term prognostic significance of the coronary computed tomography angiography (CCTA)-derived fractional flow reserve (CT-FFR) for ...

Identification of key proteins and pathways in myocardial infarction using machine learning approaches.

Acute myocardial infarction (AMI) is a leading cause of global morbidity and mortality, requiring deeper insights into its molecular mechanisms for im...

The Application of Machine Learning in Warfarin Dose Precision for Diabetic Patients Treated with Statins: A Comparative Study.

PURPOSE: To evaluate the impact of statin therapy on warfarin dose requirements in diabetic patients and to assess the performance of various machine ...

Validation of Codes to Distinguish Between Claudication and Chronic Limb-Threatening Ischemia in Patients Undergoing Peripheral Vascular Intervention Using Medicare-Matched Registry Data.

BACKGROUND: The accuracy of contemporary administrative claims codes to discriminate between different phenotypes of peripheral artery disease is not ...

Mild to moderate COPD, vitamin D deficiency, and longitudinal bone loss: the Multi-ethnic Study of Atherosclerosis.

OBJECTIVE: Despite the established association between chronic obstructive pulmonary disease (COPD) severity and risk of osteoporosis, even after acco...

Macrophage histone lactylation in atherosclerosis progression: mechanisms, predictive models, and therapeutic potential of Ruan Jian Qing Mai formula.

AIMS: This study investigates the role of macrophage histone lactylation-a protein modification-in atherosclerosis progression, particularly in periph...

A Wearable In-Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood.

The pain-free monitoring of blood-based biomarkers is essential for early detection of diseases like cancers, infections, and metabolic disorders such...

Aging at the Crossroads of Organ Interactions: Implications for the Heart.

Aging processes underlie common chronic cardiometabolic diseases such as heart failure and diabetes. Cross-organ/tissue interactions can accelerate ag...

Identification of shared mechanisms between Alzheimer's disease and atherosclerosis by integrated bioinformatics analysis.

Alzheimer's disease (AD) and atherosclerosis (AS) are two interacting diseases mostly affecting aged adults. AD is characterized by the deposition of ...

A machine learning model using echocardiographic myocardial strain to detect myocardial ischemia.

Coronary functional assessment plays a critical role in guiding decisions regarding coronary revascularization. Traditional methods for evaluating fun...

Association between atherogenicity indices and prediabetes: a 5-year retrospective cohort study in a general Chinese physical examination population.

BACKGROUND AND OBJECTIVE: Atherogenicity indices have emerged as promising markers for cardiometabolic disorders, yet their relationship with prediabe...

Interpretable machine learning prediction model for major adverse cardiovascular events in patients with peripheral artery disease.

BACKGROUND: Major adverse cardiovascular events (MACEs) are severe complications of peripheral arterial disease (PAD), associated with a poor prognosi...

Cardiovascular imaging in 2024: review of current research and innovations.

Cardiovascular imaging saw significant advancements in 2024, impacting technology, pathophysiology, and clinical applications. This review provides a ...

Dynamic Predictive Models of Cardiogenic Shock in STEMI: Focus on Interventional and Critical Care Phases.

: While early risk stratification in STEMI is essential, the threat of cardiogenic shock (CS) persists after revascularization due to reperfusion inju...

Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.

Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains crucial in preventing and treating CAD-associated thr...

Circulating fibroblast growth factor 21 is associated with blood pressure in the Chinese population: a community-based study.

BACKGROUND: Our research team previously found that fibroblast growth factor (FGF) 21, a circulating hormone, was significantly associated with athero...

Serum sclerostin as a marker of microvascular and macrovascular complications among children and adolescents with type 1 diabetes mellitus.

BACKGROUND: Uncontrolled diabetes mellitus (DM) accelerates atherosclerosis and vascular diseases, leading to micro- and macrovascular complications. ...

Iron-dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP-1 monocytes.

Atherosclerosis leading to cardiovascular diseases remains a dominant medical problem. In the early stages of this disease, the interaction between ci...