Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Alterations in the functional MRI-based temporal brain organisation in individuals with obesity.

AIMS: Obesity is associated with functional alterations in the brain. Although spatial organisation changes in the brains of individuals with obesity have been widely studied, the temporal dynamics in their brains remain poorly understood. Therefore, in this study, we investigated variations in the intrinsic neural timescale (INT) across different degrees of obesity using resting-state functional ...

Jun 25 2025 40566750

[Implementation of artificial intelligence (AI) in healthcare: historical development, current technologies and challenges].

The historical development of artificial intelligence (AI) in healthcare since the 1960s shows a transformation from simple rule-based systems to complex, data-driven approaches. Early applications focused on decision support, while innovative systems use neural networks and machine learning to recognise patterns in large datasets. The integration of AI technologies in medicine has given rise to d...

Jun 25 2025 40560227
Using a Multilingual AI Care Agent to Reduce Disparities in Colorectal Cancer Screening for Higher Fecal Immunochemical Test Adoption Among Spanish-Speaking Patients: Retrospective Analysis.

BACKGROUND: Colorectal cancer (CRC) screening rates remain disproportionately low among Hispanic and Latino populations compared to non-Hispanic White...

Jun 25 2025 40561471
Suicide Risk Screening in Jails: Protocol for a Pilot Study Leveraging the Mental Health Research Network Algorithm and Health Care Data.

BACKGROUND: Suicide in local jails occurs at a higher rate than in the general population, requiring improvements to risk screening methods. Current s...

Jun 25 2025 40561472
Challenges and opportunities in assessing right ventricular structure and function: a Roadmap for standardization, clinical implementation and research.

Given its crucial role in determining patient symptoms and outcomes in various cardiopulmonary diseases, the thorough and accurate assessment of right...

Jun 25 2025 40562802
Machine learning prediction of intestinal α-glucosidase inhibitors using a diverse set of ligands: a drug repurposing effort with drugBank database screening.

UNLABELLED: The global rise in diabetes mellitus (DM) poses a significant health challenge, necessitating effective therapeutic interventions. α-Gluco...

Jun 25 2025 40575395
Application of IRSA-BP neural network in diagnosing diabetes.

Within the healthcare sector, the application of machine learning is gaining prominence, notably enhancing the efficiency and precision of diagnostic ...

Jun 25 2025 40560874
Personalized machine learning models for noninvasive hypoglycemia detection in people with type 1 diabetes using a smartwatch: Insights into feature importance during waking and sleeping times.

Hypoglycemia is a major challenge for people with diabetes. Therefore, glycemic monitoring is an important aspect of diabetes management. However, cur...

Jun 25 2025 40560992
Neural network prediction model based on Levy flight and natural biomimetic technology for its application in cancer prediction.

Precise forecasting of cancer outcomes is essential for medical professionals to assess the well-being of patients and develop customized therapeutic ...

Jun 25 2025 40561113
Big data and cardiovascular risk-insights into obesity, diabetes, and coronary heart disease.

BACKGROUND: Cardiovascular diseases (CVD) remain a major global health burden. Obesity and type 2 diabetes mellitus (T2DM) are key modifiable risk fac...

Jun 24 2025 40553126
AI-based large-scale screening of gastric cancer from noncontrast CT imaging.

Early detection through screening is critical for reducing gastric cancer (GC) mortality. However, in most high-prevalence regions, large-scale screen...

Jun 24 2025 40555751
Prime editor-based high-throughput screening reveals functional synonymous mutations in human cells.

Synonymous mutations are generally considered neutral, while their roles in the human genome remain largely unexplored. Here we use the PEmax system t...

Jun 24 2025 40555761
Artificial intelligence for predicting the risk of bone fragility fractures in osteoporosis.

Osteoporosis is widespread with a high incidence rate, resulting in fragility fractures which are a major contributor to mortality among the elderly. ...

Jun 24 2025 40555880
Patient acceptability of CITOBOT for cervical cancer screening: A mixed-method study.

This study assessed the acceptability of CITOBOT, a device for early cervical cancer screening in a real-world pilot setting as part of a translationa...

Jun 24 2025 40554577
The early prediction of neonatal necrotizing enterocolitis in high-risk newborns based on two medical center clinical databases.

: Early identification and timely preventive interventions play an essential role for improving the prognosis of newborns with necrotizing enterocolit...

Jun 23 2025 40550736
Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk.

BACKGROUNDObesity, a growing health concern, often leads to metabolic disturbances, systemic inflammation, and vascular dysfunction. Emerging evidence...

Jun 23 2025 40548377
Machine learning-based QSAR and molecular modeling identify promising PTP1B modulators from Ocimum gratissimum for type 2 diabetes therapy.

Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin signaling and a promising therapeutic target for the treatment of type ...

Jun 23 2025 40549293
Structure-based screening of small-molecule interleukin-23 inhibitors inspired by monoclonal antibody interactions.

Interleukin-23 (IL-23) is a key driver of chronic inflammatory diseases, yet current therapies rely on costly monoclonal antibodies. This study aims t...

Jun 23 2025 40549294
Association rule mining of the human gut microbiome.

The human gut carries a vast and diverse microbial community that is essential for human health. Understanding the structure of this complex community...

Jun 23 2025 40550997
Effectiveness and safety of AI-driven closed-loop systems in diabetes management: a systematic review and meta-analysis.

BACKGROUND: Diabetes is a metabolic disease that can lead to severe cardiovascular diseases and neuropathy. The associated medical costs and complicat...

Jun 23 2025 40551160
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