Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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A Wearable In-Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood.

The pain-free monitoring of blood-based biomarkers is essential for early detection of diseases like cancers, infections, and metabolic disorders such as diabetes. While research often focuses on venous blood analysis, menstruation blood is an overlooked but promising source. Evidence shows a strong correlation between biomarker levels in menstruation and venous blood for many clinical analytes. A...

May 24 2025 40411388

Accuracy of Using Weight and Length in Children under 24 mo to Screen for Early Childhood Obesity: A Systematic Review.

The global increase in early childhood overweight and obesity has prompted interest in early prediction of overweight and obesity to allow timely intervention and prevent lifelong consequences. A systematic review was conducted to assess the accuracy and feasibility of predicting overweight and obesity in individual children aged 3-7 y using data available in healthcare and community settings on c...

May 24 2025 40419216
Predictive machine learning model for 30-day hospital readmissions in a tertiary healthcare setting.

MOTIVATION: Hospital readmissions represent a major challenge for healthcare systems due to their impact on patient outcomes and associated costs. As ...

May 24 2025 40502443
Mechanisms underlying obesity-malignancy connection: a systematic narrative review.

The association between obesity and cancer risk carries substantial public health ramifications as obesity promotes cancer advancement via many cellul...

May 23 2025 40408050
A Joint Geometric Topological Analysis Network (JGTA-Net) for Detecting and Segmenting Intracranial Aneurysms.

OBJECTIVE: The rupture of intracranial aneurysms leads to subarachnoid hemorrhage. Detecting intracranial aneurysms before rupture and stratifying the...

May 23 2025 40408207
Ovarian Cancer Screening: Recommendations and Future Prospects.

Ovarian cancer remains a significant cause of mortality among women, largely due to challenges in early detection. Current screening strategies, inclu...

May 23 2025 40409285
Investigating the Mechanisms of Pazopanib-induced Hepatotoxicity: Insights from Network Toxicology, Microarray Analysis, and Machine Learning.

BACKGROUND: Pazopanib is an oral multi-kinase inhibitor that is effective in treating various tumors. However, it is commonly associated with hepatoto...

May 23 2025 40417760
Cost-effectiveness of the 3E model in diabetes management: a machine learning approach to assess long-term economic impact.

BACKGROUND: This study investigated the cost-effectiveness and clinical impact of the 3E model (education, empowerment, and economy) in diabetes manag...

May 23 2025 40487535
Personalized cardiometabolic care powered by artificial intelligence.

Advancements in artificial intelligence (AI) are providing a wealth of opportunities for improving clinical practice and healthcare delivery. It is pr...

May 23 2025 40487762
Graph convolutional neural networks improved target-specific scoring functions for cGAS and kRAS in virtual screening.

In the drug discovery process, traditional structure-based virtual screening methods, such as molecular docking, are often limited by empirical scorin...

May 23 2025 40510763
Cardiovascular, Kidney, Liver, and Metabolic Interactions in Heart Failure: Breaking Down Silos.

Over the past few decades, the rising burden of metabolic disease, including type 2 diabetes, prediabetes, obesity, and metabolic dysfunction-associat...

May 22 2025 40403106
Aging at the Crossroads of Organ Interactions: Implications for the Heart.

Aging processes underlie common chronic cardiometabolic diseases such as heart failure and diabetes. Cross-organ/tissue interactions can accelerate ag...

May 22 2025 40403108
Transcriptome combined with Mendelian randomization to identify key genes related to polyamine metabolism in childhood obesity and elucidate their molecular regulatory mechanisms.

Currently, research has found a close correlation between childhood obesity (CO) and elevated levels of polyamines in the bloodstream. Thus, the ident...

May 22 2025 40404777
The knowledge distillation-assisted multimodal model for osteoporosis screening.

BACKGROUND AND OBJECTIVE: Osteoporosis is characterized by reduced bone mass and deterioration of bone structure, yet screening rates prior to fractur...

May 22 2025 40483842
Induced Pluripotent Stem Cells in Cardiomyopathy: Advancing Disease Modeling, Therapeutic Development, and Regenerative Therapy.

Cardiomyopathies are a heterogeneous group of heart muscle diseases that can lead to heart failure, arrhythmias, and sudden cardiac death. Traditional...

May 22 2025 40507801
Meta-analysis of shotgun sequencing of gut microbiota in obese children with MASLD or MASH.

Alterations in the gut microbiome affect the development and severity of metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic...

May 21 2025 40396204
Accelerated discovery of ultraincompressible, superhard materials physics-enhanced active learning.

The discovery of ultraincompressible, superhard materials is constrained by the high computational cost of screening vast chemical spaces using densit...

May 21 2025 40395162
Machine learning algorithms to predict the risk of hyperlipidemia in people living with HIV after starting HAART for 6 months.

OBJECTIVE: The purpose of this study was to use machine learning models to predict the risk of hyperlipidemia in people living with HIV (PLWHs) for 6 ...

May 21 2025 40396199
Discovery of novel potential 11β-HSD1 inhibitors through combining deep learning, molecular modeling, and bio-evaluation.

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been shown to play an important role in the treatment of impaired glucose tolerance, insulin re...

May 21 2025 40397334
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