Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Machine learning-driven integration of 24-hour ambulatory blood pressure and its variability.

Twenty-four hour ambulatory blood pressure (BP) monitoring (24-hour ABPM) is considered the best out-of-office BP measurement to assess hypertension. Yet, the complexity of the obtained data, hinders their interpretation. Therefore, in this study, we investigated whether a clustering algorithm could facilitate the integrative interpretation of 24-hour ambulatory BP and its variability to construct...

Jul 16 2026 42461783

Behavior Change Content and Implementation of Large Language Model-Driven Conversational Agents in Cardiometabolic Care: Scoping Review.

BACKGROUND: Large language models (LLMs) are increasingly embedded in conversational agents for cardiometabolic care. These systems could support self-management, but their behavior change content, delivery mechanisms, and implementation transparency are poorly understood. OBJECTIVE: This scoping review mapped behavior change techniques (BCTs) used in LLM-driven conversational agents for cardiomet...

Jul 15 2026 42456008
Evaluation of deep learning architectures for predicting ligand interactions with neurologically relevant GPCRs.

G protein-coupled receptors (GPCRs) are therapeutic targets for over 30% of approved drugs, yet specific GPCR subtypes act as molecular initiating eve...

Jul 15 2026 42458575
From unlabeled to labeled: self-supervised deep learning in computational pathology.

PURPOSE: The advancement of decision support systems for pathology and their implementation in clinical practice have been limited by the necessity fo...

Jul 15 2026 42458576
Leveraging Advanced AI Frameworks for Dual PPAR α/γ Agonist Discovery in Alzheimer's Disease.

The dual activating potential of peroxisome proliferator-activated receptors (PPAR) α and γ offers a promising way to address metabolic issues, neuroi...

Jul 15 2026 42458794
Occupational therapists' use of digital technologies to support people with disabilities in engaging in occupation: a scoping review protocol.

INTRODUCTION: Digital tools such as virtual reality, mobile applications and digital devices are being implemented across various healthcare practice ...

Jul 15 2026 42463191
Prevalence of hypertension and diabetes in Bangladesh: identifying gaps in awareness and misinformation.

OBJECTIVE: Non-communicable diseases (NCDs) are a growing health burden in low- and middle-income countries, with hypertension and poor glycaemic cont...

Jul 15 2026 42449339
Chest Radiograph-based Artificial Intelligence for Osteoporosis: Accuracy and Associations With Fracture and Mortality.

OBJECTIVES: To evaluate an AI tool for opportunistic osteoporosis screening using chest radiographs (CXRs), focusing on its diagnostic accuracy agains...

Jul 15 2026 42452786
Current and Novel Biomarkers for Diagnosis and Subtyping of Primary Aldosteronism.

Primary aldosteronism is a common and potentially curable cause of secondary hypertension, yet it remains substantially underdiagnosed. Current diagno...

Jul 15 2026 42454396
Application of AI in Hypertension Health Education: Scoping Review.

BACKGROUND: Hypertension is a major global health challenge, and effective health education is crucial for improving patients' self-management. Tradit...

Jul 15 2026 42456158
Passive Screening for Depressive Symptoms Using Daily Wrist Actigraphy and Deep Learning: Model Development and Validation Study.

BACKGROUND: Depressive symptoms are common yet often underrecognized in routine care, underscoring the need for scalable screening approaches beyond e...

Jul 15 2026 42456159
Assessing Quality, Readability, and Transparency of Online and AI-Generated Information on Type 2 Diabetes Mellitus: Cross-Sectional Exploratory Study.

BACKGROUND: Type 2 diabetes mellitus (T2DM) affects approximately 590 million people worldwide, and its management relies heavily on patient education...

Jul 15 2026 42456170
Auxiliary-conditioned cross-attention with physiologically interpretable features for Chagas disease detection from 12-lead ECGs.

OBJECTIVE: Chagas disease remains a major public-health concern in endemic regions, and chronic cardiac involvement often manifests as conduction abno...

Jul 15 2026 42456743
Deep learning interpretation of echocardiographic images predicts incident heart failure and subtypes.

BACKGROUND: Accurate prediction of incident heart failure (HF) may help prioritize HF preventive therapies. Deep learning interpretation of echocardio...

Jul 15 2026 42457081
Quality indicators for cancer pain management: natural language processing and machine learning from electronic clinical records.

OBJECTIVES: The continual evaluation of quality indicators (QIs) for cancer pain management is essential to maintaining and improving its quality. How...

Jul 15 2026 42457547
Interpretable machine learning for predicting mild cognitive impairment in elderly patients with type 2 diabetes mellitus: model development and performance assessment.

Type 2 diabetes mellitus (T2DM) is a prevalent chronic condition, particularly in the elderly, and is associated with an increased risk of cognitive d...

Jul 15 2026 42457788
A Comparative Study of the Psychometrics and Feasibility of Artificial Intelligence Algorithms Versus the Standard Screening Methods for Oropharyngeal Dysphagia in Older Adults: A Scoping Review.

Oropharyngeal dysphagia (OD) is highly prevalent (35.6%-47.4%) in hospitalized older patients but clinical screening is slow and labor-intensive, lead...

Jul 15 2026 42458026
Future of CT body composition research: Methodological discrepancies and advances.

Body composition research utilizing computed tomography (CT) has increased over the past several decades as researchers use clinically acquired CT for...

Jul 15 2026 42458225
Explainable Machine-Learning Model for Predicting Severe Obstructive Sleep Apnea in Patients Undergoing Metabolic Bariatric Surgery.

BACKGROUND: Severe obstructive sleep apnea (SOSA) is associated with an increased risk of perioperative complications in patients undergoing metabolic...

Jul 15 2026 42449080
A framework for assessing algorithmic discrimination risks in training data: a case of pediatric type 1 diabetes.

OBJECTIVES: To develop a generalizable framework for identifying algorithmic discrimination risks arising from subgroup imbalances in machine learning...

Jul 14 2026 42459945
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