Primary Care

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A proteogenomic atlas of idiopathic pulmonary arterial hypertension reveals sex-dimorphic mechanisms and potential novel therapeutic targets

Current circulating biomarkers for idiopathic pulmonary arterial hypertension (IPAH) lack specificity for preclinical detection and fail to capture the biological heterogeneity driving disease progression. Furthermore, molecular mechanisms underlying the “sex paradox” of IPAH, where females exhibit higher susceptibility but lower mortality, remain poorly understood, hindering the development of pr...

A novel open access multimodal dataset of nodule imaging and circulating proteome from a lung cancer screening cohort

Low-dose computed tomography (LDCT) lung cancer screening has significantly enhanced early detection and patient survival rates in the population at risk. Current screening methods, that primarily rely on LDCT imaging, will very likely benefit from molecular biomarkers to achieve a more comprehensive, accurate, personalized and non-invasive risk assessment leveraging multimodal tools. We present a...

Machine Learning-Driven Classification of Type 2 Diabetes Using Gut Microbiome Profiles for Enhanced Detection and Personalised Therapeutics

The purpose of the study is to investigate Type 2 Diabetes Mellitus (T2DM) progression and risk through investigating gut microbiome biomarkers, provi...

Comparing the Treatment and Side Effects of Existing Bariatric Surgery Procedures: An Observational Study

Bariatric surgery is an established treatment for obesity and its associated comorbidities, including diabetes, hypertension, sleep apnea, and hyperch...

Alzheimer's disease detection based on large language model prompt engineering

In light of the growing proportion of older individuals in our society, the timely diagnosis of Alzheimer's disease has become a crucial aspect of h...

A novel approach to finding the compositional differences and biomarkers in gut microbiota in type 2 diabetic patients via meta-analysis, data-mining, and multivariate analysis.

BACKGROUND/PURPOSE OF THE STUDY: Type 2 diabetes mellitus (T2DM)-one of the fastest globally spreading diseases-is a chronic metabolic disorder charac...

Jan 1 2025 40514168
The translational power of Alzheimer's-based organoid models in personalized medicine: an integrated biological and digital approach embodying patient clinical history.

Alzheimer's disease (AD) is a complex neurodegenerative condition characterized by a multifaceted interplay of genetic, environmental, and pathologica...

Jan 1 2025 40443709
The multikinetic fusion feature of PPG was combined with MCNN_vision_transformer for diabetes detection.

BACKGROUND: Diabetes is a chronic condition that significantly impacts the cardiovascular system and various other organs. Photoplethysmogram (PPG) si...

Jan 1 2025 40535639
Inflammatory activity levels on patients with anti-TNF therapy: most important factors and a decision tree model based on REGISPONSER and RESPONDIA registries.

BACKGROUND: The effectiveness of anti-tumour necrosis factor (TNF) therapy in spondyloarthritis is traditionally associated with factors such as age, ...

Jan 1 2025 40376606
European strategies in the screening of biliary atresia: a scoping review.

BACKGROUND: Biliary atresia (BA) is a rare condition that meets the criteria for neonatal screening. Taiwan province of China led the way in BA screen...

Jan 1 2025 40385242
Emerging biomaterials and bio-nano interfaces in pulmonary hypertension therapy: transformative strategies for personalized treatment.

Pulmonary hypertension (PH) is still an aggressive and progressive illness with vascular remodeling and right heart failure despite the therapeutic ad...

Jan 1 2025 40416311
Sex-Specific Ensemble Models for Type 2 Diabetes Classification in the Mexican Population.

BACKGROUND: Type 2 diabetes (T2D) is considered a global pandemic by the World Health Organization (WHO), with a growing prevalence, particularly in M...

Jan 1 2025 40356710
Machine learning with decision curve analysis evaluates nutritional metabolic biomarkers for cardiovascular-kidney-metabolic risk: an NHANES analysis.

BACKGROUND: The American Heart Association recently introduced the concept of Cardiovascular-Kidney-Metabolic Syndrome (CKM), emphasizing the interpla...

Jan 1 2025 40406158
Critical review of OCT in clinical practice for the assessment of oral lesions.

BACKGROUND: Optical Coherence Tomography (OCT) is an advanced imaging technique that is widely used in ophthalmology and is increasingly being applied...

Jan 1 2025 40406268
Protocol for evaluating the cost-effectiveness of Mongolia's sugar-sweetened beverages tax using double machine learning.

Elevated consumption of sugar-sweetened beverages (SSBs) has been associated with an increase in obesity, type 2 diabetes, and other non-communicable ...

Jan 1 2025 40493559
Development and validation of an interpretable longitudinal preeclampsia risk prediction using machine learning.

Preeclampsia is a pregnancy-specific disease characterized by new onset hypertension after 20 weeks of gestation that affects 2-8% of all pregnancies ...

Jan 1 2025 40493626
Exploring the effect of the triglyceride-glucose index on bone metabolism in prepubertal children, a retrospective study: insights from traditional methods and machine-learning-based bone remodeling prediction.

BACKGROUND: Childhood obesity poses a significant risk to bone health, but the impact of insulin resistance (IR) on bone metabolism in prepubertal chi...

Jan 1 2025 40416622
Effect of artificial intelligence driven therapeutic lifestyle changes (AI-TLC) intervention on health behavior and health among obesity pregnant women in China: a randomized controlled trial protocol.

INTRODUCTION: Obesity has reached epidemic proportions globally, posing significant challenges to public health and economic stability. In China, the ...

Jan 1 2025 40421363
Machine learning-based coronary heart disease diagnosis model for type 2 diabetes patients.

BACKGROUND: To establish a classification model for assisting the diagnosis of type 2 diabetes mellitus (T2DM) complicated with coronary heart disease...

Jan 1 2025 40475993
How should artificial intelligence be used in breast screening? Women's reasoning about workflow options.

Studies show that breast screening participants are open to artificial intelligence (AI) in breast screening, but hold concerns about AI performance, ...

Jan 1 2025 40446203
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