Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Computation-Driven Experimental Discovery of Reactivity Space of Organoboron Compounds.

ConspectusOrganoboron compounds serve as fundamental building blocks in the construction of diverse functional molecules, ranging from pharmaceuticals to materials. The discovery of boron-related new chemical transformations serves as a pivotal driving force for developing functional substances. Nevertheless, de novo design of new reactions remains challenging, requiring both the elucidation of co...

Apr 8 2026 41952304

Hybrid experimental-QSAR-artificial intelligence framework for chronic ecological risk assessment of emerging pollutants in coastal environments.

Urbanized coastal zones are increasingly exposed to complex mixtures of pharmaceuticals and illicit drug markers (PhACs), yet ecological risk assessment (ERA) remains constrained by limited experimental chronic toxicity data, particularly for marine environments. Here, we applied an integrated Weight-of-Evidence (WoE) framework combining experimentally derived ecotoxicological endpoints with quant...

Apr 8 2026 41955777
"Unpatients" in haemostasis and thrombosis. A yardstick of current paths in healthy carriers of a genetic susceptibility.

"Unpatients" are health-conscious individuals -carrying a genetic susceptibility whose impact is unclear with respect to the risk of a clinical event-...

Apr 8 2026 41956942
Opportunistic Screening on Chest CT, From the AJR Special Series on Screening.

The increase in chest CT volumes affords radiologists the opportunity to systematically assess imaging biomarkers, including coronary and thoracic art...

Apr 8 2026 40668630
Association Between Breast Arterial Calcifications and Increased Cardiovascular Risk: A Canadian Perspective on Clinical Implications and the Potential Role in Preventive Care.

Breast arterial calcifications (BAC) are associated with increased cardiovascular risk and have been correlated with other methods of cardiovascular r...

Apr 8 2026 41948945
Health Prediction Using Hybrid Deep Learning Models: A Transparent and Interpretable Approach.

Obesity has become alarming globally, with mounting health emergencies related to a number of chronic conditions like cardiovascular disease, diabetes...

Apr 8 2026 41948999
High-accuracy retinal age prediction via fundus-based multitask learning reveals the effect of systemic disease.

BACKGROUND: Accurate estimation of the retinal age, defined as the age predicted from fundus photographs by a deep-learning model trained on chronolog...

Apr 8 2026 41951870
Plasma proteomic signatures linking preserved ratio impaired spirometry to cardiometabolic diseases and multimorbidity: A longitudinal cohort study.

BACKGROUND: Preserved ratio impaired spirometry (PRISm), defined by reduced FEV1 with preserved FEV1/FVC ratio, has been linked to cardiometabolic dis...

Apr 7 2026 41944044
Multimodal fusion of speech and PHQ-9 for machine learning-based adolescent depression screening.

BACKGROUND: Traditional screening for adolescent depression primarily relies on self-reported symptoms. However, this method is vulnerable to under-re...

Apr 7 2026 41956220
An Expedited Chart Review Process for Large Database Studies Using Natural Language Processing and Multiwave Adaptive Sampling.

BACKGROUND: One of the ways to enhance analyses conducted with large claims databases is by validating the measurement characteristics of the code-bas...

Apr 7 2026 41944789
Three-Dimensional human motion analysis using LiDAR technology: A systematic review.

3D Light Detection and Ranging (LiDAR) has gained increasing attention in the field of human motion analysis due to its capability to non-invasively c...

Apr 7 2026 42001760
Transforming oncology clinical trial matching through neuro-symbolic, multi-agent AI and an oncology-specific knowledge graph: a prospective evaluation in 3804 patients.

BACKGROUND: Clinical trial enrollment in oncology remains critically low, with fewer than 5% of eligible adults participating, in large part due to th...

Apr 7 2026 42004487
Predictive performance of artificial intelligence algorithms for gestational diabetes mellitus in pregnant women: a protocol for systematic review and meta-analysis.

BACKGROUND: Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication that can pose numerous adverse health effects on both mothers an...

Apr 7 2026 41947236
Predicting Longitudinal Caries Trajectories from Childhood to Early Adulthood.

Prior studies have used traditional trajectory analyses to classify caries progression; however, none have applied machine learning (ML) to predict ca...

Apr 7 2026 41947516
Data-Driven Tooth Selection Enhances Partial-Mouth Periodontal Screening.

The high prevalence of periodontitis has imposed a significant global disease burden. Epidemiologic surveys rely on full-mouth periodontal examination...

Apr 7 2026 41947526
Large-scale AI analysis reveals missed opportunities in albuminuria testing and disease-modifying therapy implementation.

BACKGROUND: Albuminuria is a key diagnostic and prognostic biomarker of chronic kidney disease (CKD), associated with adverse cardiovascular and renal...

Apr 7 2026 41950426
Beyond Weight: Systems Biology and Precision Medicine Redefine Obesity as a Multidimensional Disease.

BACKGROUND: Traditional weight-centered models do not fully capture the biological complexity of obesity. Systems biology offers a new framework by in...

Apr 7 2026 41944002
Advances in intelligent multi-mode lateral flow assays: from multi-metallic nanomaterials to smart analytical integration.

Lateral flow assays (LFAs) have evolved from simple qualitative tools into intelligent, multi-modal analytical platforms that integrate rationally eng...

Apr 7 2026 41944616
Optimizing the management of periprosthetic infections with artificial intelligence: current evidence and future directions.

Periprosthetic joint infections (PJIs) are a serious complication in both primary arthroplasty and revision arthroplasty, posing a major challenge in ...

Apr 7 2026 41945564
Feasibility and Acceptability of AI-Powered Tools for Early Autism Screening in Egypt: Semistructured Focus Group Study.

BACKGROUND: Autism spectrum disorder (ASD) is often underdiagnosed in low- and middle-income countries due to limited specialist access, sociocultural...

Apr 7 2026 41945920
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