Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Adaptive Temporal Mixture of Experts for Predicting Stiffness Metrics from the Ocular Response Analyzer and Identifying Keratoconus: Stiffness Estimates from Ocular Response Analyzer.

PURPOSE: To develop a machine learning-based modeling approach for extracting elastic stiffness estimates from Ocular Response Analyzer (ORA) waveforms. DESIGN: Prospective observational cohort study with model training and testing using development dataset and validation with independent dataset. SUBJECTS: Participants were prospectively enrolled into six cohorts for the Development dataset, incl...

Feb 26 2026 41763592

Advancement in peptide-based therapeutics for the treatment of type 2 diabetes mellitus: current progress and future prospects.

Diabetes is a chronic medical disorder caused by insufficient production of the hormone insulin by the pancreas. Although there are various treatment options available for controlling diabetes, including non-peptide-based medications, the majority of these have adverse effects and are limited in comparison to peptide-based drugs. Protein drugs offer numerous benefits, including weight loss, signif...

Feb 26 2026 41746526
Generative AI Uncovers Novel Chrebp/Txnip Axis Inhibitors with Potential Anti-inflammatory Activity.

Type 2 diabetes is driven in part by metabolic inflammation, where activation of the Chrebp/Txnip axis promotes NLRP3 inflammasome assembly, leading t...

Feb 26 2026 41746845
Application of machine learning for predicting aflatoxin contamination risk in maize from Texas.

In this study, we developed models for predicting aflatoxin contamination in Texas maize samples. These models were trained on individual or median hi...

Feb 26 2026 41747161
Smartphone App Using Reinforcement Learning for Obesity: Single-Arm Feasibility Study.

BACKGROUND: While behavioral interventions remain an evidence-based treatment for obesity, they often require long durations and frequent sessions. To...

Feb 26 2026 41747193
Exploring stress and coping among black women in early midlife with elevated blood pressure in a safety-net health system: a qualitative focus group protocol.

INTRODUCTION: Black women in early midlife experience disproportionate exposure to stress and elevated cardiovascular risk, including hypertension. De...

Feb 26 2026 41748187
Present state and future of screening for atrial fibrillation: a state-of-the-art review.

Atrial fibrillation (AF) is the most common arrhythmia and is a leading cause of stroke and heart failure yet often remains undiagnosed. Screening has...

Feb 26 2026 41748199
Explainable AI for mortality prediction: a comparative study using the MIMIC-III dataset.

OBJECTIVES: Predicting mortality is vital for tailoring treatments, improving care and reducing costs. Machine learning (ML) has shown strong potentia...

Feb 26 2026 41748202
A device-invariant multi-modal learning framework for respiratory disease classification.

Recent advances in cough sound analysis using deep learning techniques enable smartphone-based respiratory disease screening suitable for self-managem...

Feb 26 2026 41748911
Explainable deep learning framework incorporating medical knowledge for insulin titration in diabetes.

BACKGROUND: Deep learning has shown promise in diabetes management but faces challenges in real-world application due to its "black-box" nature, chara...

Feb 26 2026 41748914
Decoding cardiovascular risk in Chinese middle-aged and elderly adults: a 9-year prospective study integrating machine learning with explainable AI based on CHARLS cohort.

BACKGROUND: Cardiovascular disease constitutes the most formidable public health challenge in China, accounting for 48.98% and 47.35% of mortality in ...

Feb 26 2026 41749231
Interpretable machine learning for chronic kidney disease prediction: Insights from SHAP and LIME analyses.

Chronic kidney disease (CKD) is a progressive condition requiring early detection for optimal patient outcomes. This study developed an interpretable ...

Feb 26 2026 41747002
Random forest-based QSAR and molecular dynamics insights into steroidal pregnanes as 11β-hydroxysteroid dehydrogenase type 1 modulators for type 2 diabetes.

The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a validated therapeutic target for type 2 diabetes mellitus due to its role in local ...

Feb 25 2026 41775123
Assessing the completeness of reporting in imaging studies using artificial neural network models for cancer diagnosis: Adherence to the TRIPOD-AI guideline.

BACKGROUND: Developments in artificial neural networks (ANNs) offer significant promise for cancer screening and risk prediction, with the potential t...

Feb 25 2026 41775155
Cardiovascular Science, Medicine, and Society: The Brave New World: The ACC Braunwald Lecture 2025.

Recent scientific and technological advances have dramatically expanded the possibilities in cardiovascular medicine. Landmark clinical trials have in...

Feb 25 2026 41739019
External Validation of an AI-Based Colonoscopy Quality Assessment Tool in Japanese Clinical Practice: A Pilot Study.

BACKGROUND: While AI-assisted polyp detection has advanced significantly, comprehensive AI-based colonoscopy quality assessment tools remain limited. ...

Feb 25 2026 41739329
Teleophthalmology Programs in Underserved Communities in the United States: A Narrative Review.

Underserved communities in the United States continue to face substantial barriers to accessing eye care, leading to preventable vision loss. This rev...

Feb 25 2026 41740052
Reducing Educational Bias in Cognitive Assessment via Dynamic Support Vector Machine Weighting: Validation Study on an Education-Stratified Dataset.

BACKGROUND: The Mini-Mental State Examination (MMSE) remains widely used for cognitive screening, yet its performance varies substantially across educ...

Feb 25 2026 41740092
A neuroimaging functional connectivity signature of emotional conflict monitoring predicting cognitive decline in type 2 diabetes.

Type 2 diabetes (T2D) is associated with cognitive decline and neurodegenerative disorders. Changes in the connections between brain regions responsib...

Feb 25 2026 41741619
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