Prostate Cancer

Ultrasound prostate segmentation based on multidirectional deeply supervised V-Net.

PURPOSE: Transrectal ultrasound (TRUS) is a versatile and real-time imaging modality that is commonly used in image-guided prostate cancer interventions (e.g., biopsy and brachytherapy). Accurate segmentation of the prostate is key to biopsy needle placement, brachytherapy treatment planning, and motion management. Manual segmentation during these interventions is time-consuming and subject to int...

Intelligent inverse treatment planning via deep reinforcement learning, a proof-of-principle study in high dose-rate brachytherapy for cervical cancer.

Inverse treatment planning in radiation therapy is formulated as solving optimization problems. The objective function and constraints consist of multiple terms designed for different clinical and practical considerations. Weighting factors of these terms are needed to define the optimization problem. While a treatment planning optimization engine can solve the optimization problem with given weig...

A machine-learning-based prediction model of fistula formation after interstitial brachytherapy for locally advanced gynecological malignancies.

PURPOSE: External beam radiotherapy combined with interstitial brachytherapy is commonly used to treat patients with bulky, advanced gynecologic cance...

Development and clinical implementation of SeedNet: A sliding-window convolutional neural network for radioactive seed identification in MRI-assisted radiosurgery (MARS).

PURPOSE: To develop and evaluate a sliding-window convolutional neural network (CNN) for radioactive seed identification in MRI of the prostate after ...

Efficacy and safety of CT-guided high-dose-rate interstitial brachytherapy in primary and secondary malignancies of the pancreas.

PURPOSE: To evaluate efficacy and safety of CT-guided iBT in patients with primary and secondary malignancies of the pancreas.

Focusing aptamer selection on the glycan structure of prostate-specific antigen: Toward more specific detection of prostate cancer.

The development of chemical sensors capable of detecting the specific glycosylation patterns of proteins offers a powerful mean for the early detectio...

Serum Procalcitonin and Presepsin Levels in Patients with Generalized Pustular Psoriasis.

Patients with generalized pustular psoriasis (GPP) often present with symptoms that must be differentiated from sepsis. Procalcitonin (PCT) and presep...

Metal artifact reduction on cervical CT images by deep residual learning.

BACKGROUND: Cervical cancer is the fifth most common cancer among women, which is the third leading cause of cancer death in women worldwide. Brachyth...

Combined Low Dose Rate Brachytherapy and External Beam Radiation Therapy for Intermediate-Risk Prostate Cancer.

INTRODUCTION: This is a retrospective study conducted to report the tumor control and late toxicity outcomes of patients with intermediate-risk prosta...

Predicting Advanced Prostate Cancer from Modeling Early Indications in Biopsy and Prostatectomy Samples via Transductive Semi-Supervised Survival Analysis.

Prostate cancer is the most prevalent form of cancer and the second most common cause of cancer deaths among men in the United States. Accurate progno...

An evaluation method of risk grades for prostate cancer using similarity measure of cubic hesitant fuzzy sets.

Prostate cancer (PC) is more common cancer in older men. Then, the existing evaluation method of PC risk grades is based on the AJCC (American Joint C...

MRI-based automated detection of implanted low dose rate (LDR) brachytherapy seeds using quantitative susceptibility mapping (QSM) and unsupervised machine learning (ML).

BACKGROUND AND PURPOSE: Permanent seed brachytherapy is an established treatment option for localized prostate cancer. Currently, post-implant dosimet...

Top-Down Fabricated Silicon Nanowire Arrays for Field-Effect Detection of Prostate-Specific Antigen.

Highly sensitive electrical detection of biomarkers for the early stage screening of cancer is desired for future, ultrafast diagnostic platforms. In ...

Association Between Serum Testosterone and Serum PSA Among Men With and Without Partial Androgen Deficiency.

Serum prostatic specific antigen (PSA) and serum testosterone levels share an undefined relationship with each other, with many conflicting studies sh...

Correlation of Prostate Cancer CHD1 Status with Response to Androgen Deprivation Therapy: a Pilot Study.

INTRODUCTION: CHD1 has been identified as a tumor suppressor gene in prostate cancer. Previous studies have shown strong associations between CHD1 del...

Automated 4-Sample Protein Immunoassays using 3D-Printed Microfluidics.

Low cost, miniaturized assay platforms that work with small sample volumes, high sensitivity and rapid detection will have high value in future biomol...

Salvage HDR Brachytherapy: Multiple Hypothesis Testing Versus Machine Learning Analysis.

PURPOSE: Salvage high-dose-rate brachytherapy (sHDRB) is a treatment option for recurrences after prior radiation therapy. However, only approximately...

Rotational paper-based electrochemiluminescence immunodevices for sensitive and multiplexed detection of cancer biomarkers.

This paper describes a novel rotational paper-based analytical device (RPAD) to implement multi-step electrochemiluminescence (ECL) immunoassays. The ...

Seven-Month Prostate-Specific Antigen Is Prognostic in Metastatic Hormone-Sensitive Prostate Cancer Treated With Androgen Deprivation With or Without Docetaxel.

Purpose We evaluated the relationship between prostate-specific antigen (PSA) and overall survival in the context of a prospectively randomized clinic...

Identifying the Presence of Prostate Cancer in Individuals with PSA Levels <20 ng ml Using Computational Data Extraction Analysis of High Dimensional Peripheral Blood Flow Cytometric Phenotyping Data.

Determining whether an asymptomatic individual with Prostate-Specific Antigen (PSA) levels below 20 ng ml has prostate cancer in the absence of defini...