Prostate Cancer

Analysis of gray zone PSA and PSAD correlated with PIRADS v2.1 in the MRI-US fusion prostate biopsy era: a retrospective bi-centre study.

BACKGROUND: Multiple parameters including PSA, PSAD, and PIRADS v2.1 score, are being associated in an effort to increase the overall detection rate of clinically significant prostate cancer (csPCa). This study aims to explore gray zone PSA and PSAD correlated with PIRADS score in the detection of csPCa using MRI-US fusion prostate biopsy.

Deep learning assisted identification of SCUBE2 and SLC16 A5 combination in RNA-sequencing data as a novel specific potential diagnostic biomarker in prostate cancer.

Despite the extensive use of biomarkers like PSA, AMACR, and PCA3, prostate cancer (PCa) is still a major clinical challenge, demanding the development of more precise and specific methods for diagnosis. In this study, a deep learning model was applied to identify ten key genes from a pool of 68 common differentially expressed genes in the three transcriptomic datasets. The model demonstrated high...

GLIO-Select: Machine Learning-Based Feature Selection and Weighting of Tissue and Serum Proteomic and Metabolomic Data Uncovers Sex Differences in Glioblastoma.

Glioblastoma (GBM) is a fatal brain cancer known for its rapid and aggressive growth, with some studies indicating that females may have better surviv...

Effective reduction of unnecessary biopsies through a deep-learning-assisted aggressive prostate cancer detector.

Despite being one of the most prevalent cancers, prostate cancer (PCa) shows a significantly high survival rate, provided there is timely detection an...

Development of a Low-Profile, Piezoelectric Robot for MR-Guided Abdominal Needle Interventions.

PURPOSE: Minimally invasive needle-based interventions are commonly used in cancer diagnosis and treatment, including procedures, such as biopsy, brac...

Open-source deep-learning models for segmentation of normal structures for prostatic and gynecological high-dose-rate brachytherapy: Comparison of architectures.

BACKGROUND: The use of deep learning-based auto-contouring algorithms in various treatment planning services is increasingly common. There is a notabl...

Clinically applicable semi-supervised learning framework for multiple organs at risk and tumor delineation in lung cancer brachytherapy.

PURPOSE: The generalization ability of deep learning-based automatic segmentation techniques for lung cancer in practical clinical applications remain...

Exploring new drug treatment targets for immune related bone diseases using a multi omics joint analysis strategy.

In the field of treatment and prevention of immune-related bone diseases, significant challenges persist, necessitating the urgent exploration of new ...

A deep learning model based on Mamba for automatic segmentation in cervical cancer brachytherapy.

This study developed and evaluated an automatic segmentation model based on the Mamba framework (AM-UNet) for rapid and precise delineation of high-ri...

Prediction of prostate biopsy outcomes at different cut-offs of prostate-specific antigen using machine learning: a multicenter study.

BACKGROUND: Machine learning (ML) is a significant area of artificial intelligence, which can improve the accuracy of predictive or diagnostic models ...

Interstitial-guided automatic clinical tumor volume segmentation network for cervical cancer brachytherapy.

Automatic clinical tumor volume (CTV) delineation is pivotal to improving outcomes for interstitial brachytherapy cervical cancer. However, the promin...

Enhancing Blood-Brain Barrier Penetration Prediction by Machine Learning-Based Integration of Novel and Existing, In Silico and Experimental Molecular Parameters from a Standardized Database.

Predicting blood-brain barrier (BBB) penetration is crucial for developing central nervous system (CNS) drugs, representing a significant hurdle in su...

An interpretable machine learning approach for detecting psoriatic arthritis in a UK primary care psoriasis cohort using electronic health records from the Clinical Practice Research Datalink.

OBJECTIVES: Develop an interpretable machine learning model to detect patients with newly diagnosed psoriatic arthritis (PsA) in a cohort of psoriasis...

Machine learning-based identification of co-expressed genes in prostate cancer and CRPC and construction of prognostic models.

The objective of this study was to employ machine learning to identify shared differentially expressed genes (DEGs) in prostate cancer (PCa) initiatio...

New Perspectives and State of the Art in Interventional Radiotherapy (Brachytherapy) for Head and Neck Tumors.

AIM: This review aims to evaluate the role of interventional radiotherapy (IRT - brachytherapy) in the clinical management of head and neck (H&N) canc...

Integrating radiological and clinical data for clinically significant prostate cancer detection with machine learning techniques.

In prostate cancer (PCa), risk calculators have been proposed, relying on clinical parameters and magnetic resonance imaging (MRI) enable early predic...

Automating the optimization of proton PBS treatment planning for head and neck cancers using policy gradient-based deep reinforcement learning.

BACKGROUND: Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task whe...

Brachytherapy Seed Placement by Robotic Bronchoscopy with Cone Beam Computed Tomography Guidance for Peripheral Lung Cancer: A Human Cadaveric Feasibility Pilot.

PURPOSE: This study evaluates the feasibility of using robotic-assisted bronchoscopy with cone beam computed tomography (RB-CBCT) platform to perform ...

Prediction of Prostate Cancer From Routine Laboratory Markers With Automated Machine Learning.

BACKGROUND: In this study, we attempted to select the optimum cases for a prostate biopsy based on routine laboratory test results in addition to pros...

Clinical Application of Deep Learning-Assisted Needles Reconstruction in Prostate Ultrasound Brachytherapy.

PURPOSE: High dose rate (HDR) prostate brachytherapy (BT) procedure requires image-guided needle insertion. Given that general anesthesia is often emp...