Psoriasis

Adapting machine learning techniques to censored time-to-event health record data: A general-purpose approach using inverse probability of censoring weighting.

Models for predicting the probability of experiencing various health outcomes or adverse events over a certain time frame (e.g., having a heart attack in the next 5years) based on individual patient characteristics are important tools for managing patient care. Electronic health data (EHD) are appealing sources of training data because they provide access to large amounts of rich individual-level ...

Sparse Inverse Covariance Estimation with L0 Penalty for Network Construction with Omics Data.

Constructing coexpression and association networks with omics data is crucial for studying gene-gene interactions and underlying biological mechanisms. In recent years, learning the structure of a Gaussian graphical model from high-dimensional data using L1 penalty has been well-studied and many applications in bioinformatics and computational biology have been found. However, besides the problem ...

Serum 25-hydroxy vitamin D levels in patients with acne vulgaris and its association with disease severity.

BACKGROUND: Since vitamin D is a recent known immunoregulatory factor in some diseases which are addressed in immune system disorders such as SLE, [ps...

Protective Effects of Thymoquinone against Methotrexate-Induced Germ Cell Apoptosis in Male Mice.

BACKGROUND: Toxic effects of anti-cancer and other drugs on the normal tissues could be reduced by the herbal plants and their fractions. This study i...

Simultaneous Quantification of Baricitinib and Methotrexate in Rat Plasma by LC-MS/MS: Application to a Pharmacokinetic Study.

Efficacy assessments using a combination of baricitinib and methotrexate necessitate the development of an analytical method for the determination of ...

Serial change of C1 inhibitor in patients with sepsis--a preliminary report.

OBJECTIVE: C1 inhibitor (C1INH) regulates not only the complement system but also the plasma kallikrein-kinin, fibrinolytic, and coagulation systems. ...

Optimized high performance liquid chromatography-ultraviolet detection method using core-shell particles for the therapeutic monitoring of methotrexate.

Methotrexate (MTX) is an antineoplastic drug, and due to its high toxicity, the therapeutic drug monitoring is strictly conducted in the clinical prac...

Early Prognostic Factors Associated with the Efficacy of Infliximab Treatment for Patients with Rheumatoid Arthritis with Inadequate Response to Methotrexate.

INTRODUCTION: Early prognostic factors for the clinical response in patients with rheumatoid arthritis (RA) after 1 year of treatment with infliximab ...

Low serum 25-hydroxyvitamin D concentrations are associated with total adiposity of children in the United States: National Health and Examination Survey 2005 to 2006.

A negative association between serum 25-hydroxyvitamn D (25[OH]D) concentrations and adiposity has been found in adults. We hypothesized that serum 25...

Characterization of the abnormal lipid profile in Chinese patients with psoriasis.

Psoriasis is a chronic inflammatory skin disease that has been associated with abnormal lipid metabolism. To characterize the lipid profile in Chinese...

Extracting motor synergies from random movements for low-dimensional task-space control of musculoskeletal robots.

In the field of human motor control, the motor synergy hypothesis explains how humans simplify body control dimensionality by coordinating groups of m...

Rapid regression of cystoid macular edema associated with cytomegalovirus retinitis in adult acute myeloid leukemia by intravitreal methotrexate combined with oral valganciclovir: A case report with comparison of binocular outcome.

Cytomegalovirus (CMV) retinitis is a late complication of organ and hematopoietic stem cell transplant, the risk of which depends on the degree of imm...

Recurrent Neural Network Approach Based on the Integral Representation of the Drazin Inverse.

In this letter, we present the dynamical equation and corresponding artificial recurrent neural network for computing the Drazin inverse for arbitrary...

Modal kinematics for multisection continuum arms.

This paper presents a novel spatial kinematic model for multisection continuum arms based on mode shape functions (MSF). Modal methods have been used ...

Learning the inverse kinetics of an octopus-like manipulator in three-dimensional space.

This work addresses the inverse kinematics problem of a bioinspired octopus-like manipulator moving in three-dimensional space. The bioinspired manipu...

Recurrent Neural Network for Computing the Drazin Inverse.

This paper presents a recurrent neural network (RNN) for computing the Drazin inverse of a real matrix in real time. This recurrent neural network (RN...

Predictors of Success of a Single-Dose Methotrexate in the Treatment of Ectopic Pregnancy.

BACKGROUND: Ectopic pregnancy (EP) is the commonest cause of maternal mortality-related death in the first trimester. Methotrexate (MTX) remains the f...

Noninvasive blood glucose sensing using near infra-red spectroscopy and artificial neural networks based on inverse delayed function model of neuron.

In this paper, a non-invasive blood glucose sensing system is presented using near infra-red(NIR) spectroscopy. The signal from the NIR optodes is pro...

Ensemble learning of inverse probability weights for marginal structural modeling in large observational datasets.

Inverse probability weights used to fit marginal structural models are typically estimated using logistic regression. However, a data-adaptive procedu...

Scalable Bayesian Optimization of Composite Functions for Image-Based Inverse Problems in Materials Characterization

Estimating physical parameters from scientific images is a common inverse problem in materials characterization that often relies on expensive physics...