Psychiatry

Therapy Without a Therapist: Chatbots and Artificial Intelligence in Mental Health.

A number of articles have heralded the use of artificial intelligence (AI) agents to serve as a replacement for human psychotherapists. Despite the rapid advancements in the use of both rule-based and generative AI programs in the recent past, an overall review shows only small impacts on certain mental health symptoms, particularly depression, and then only in the short-term. Significant strides ...

Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders.

We aimed to develop and validate a risk estimation model for developing bipolar-spectrum disorders (BSD) in psychiatrically hospitalized adolescents based on clinical characteristics, including putatively prodromal symptoms. Adolescent inpatients (ages = 12-18 years) with non-psychotic/non-BSD diagnoses were recruited for the Adolescent Mood Disorder and Psychosis Study (AMDPS), a longitudinal, pr...

Prefrontal cortex cytosolic and synaptosome proteome reveal molecular signatures of resilience to chronic social isolation stress in rats.

Chronic social isolation stress (CSIS) is a well-established preclinical model for studying stress-induced neurobiological changes and their effects o...

Deep adaptive fusion network with multimodal neuroimaging information for MDD diagnosis: an open data study.

Neuroimaging offers powerful evidence for the automated diagnosis of major depressive disorder (MDD). However, discrepancies across imaging modalities...

Natural Language Response Formats for Assessing Depression and Worry With Large Language Models: A Sequential Evaluation With Model Pre-Registration.

Large language models can transform individuals' mental health descriptions into scores that correlate with rating scales approaching theoretical uppe...

A Walk With Grief: A Personal Narrative of Coping With the Death of a Same Sex Partner in Late Life.

Grief is a complex and multifaceted process. While there is no reason to think that the grieving process would be dissimilar if an LGBTQ+ individual l...

Longitudinal multi-omics analysis of umbilical cord blood and childhood serum in Autism.

There is considerable evidence implicating maternal immune activation (MIA) and cytokine dysregulation in the pathophysiology of Autism. However, cyto...

Revealing and validating the biomarkers associated with demethylation in major depressive disorder: comprehensive insights based on bulk RNA sequencing data, single-nucleus RNA sequencing data, and clinical experiments.

BACKGROUND: The demethylation is suspected to play a role in the development of major depressive disorder (MDD), but the precise biological mechanisms...

Auto-Masked Audio Spectrogram Transformer for depression detection from speech.

BACKGROUND: Depression is a psychological disorder characterized by altered self-referential cognition and impaired emotional expression. Traditional ...

MAN-GNN: An interpretable biomarker architecture for neurodevelopmental disorders.

Neurodevelopmental disorders exhibit highly similar behavioral characteristics in clinical assessments, heavily relying on subjective behavioral repor...

Interrelations between dopaminergic-, gabaergic- and glutamatergic neurotransmitters in antipsychotic-naïve psychosis patients and the association to initial treatment response.

Preclinical evidence points to disturbances in neural networks in psychosis involving interrelations between dopaminergic-, GABAergic- and glutamaterg...

Low-Burden Detection of Clinical Worsening in Body Dysmorphic Disorder Using Smartphone Sensor and Demographic Data.

Body dysmorphic disorder (BDD) is characterized by distressing preoccupations with perceived appearance flaws, leading to functional impairment and su...

Assessing the influence of generative artificial intelligence (GenAI) on awareness and behavior in medical research integrity: An online survey study.

BACKGROUND: Generative Artificial Intelligence(GenAI) significantly enhances medical research efficiency but raises ethical concerns regarding researc...

Edge-Centric Brain Connectome Representations Reveal Increased Brain Functional Diversity of Reward Circuit in Patients With Major Depressive Disorder.

BACKGROUND: Major depressive disorder (MDD) has been increasingly understood as a disorder of network-level functional dysconnectivity. However, previ...

Interaction of artificial intelligence, mental disorders, and diverse data modalities: Potential treatment management based on the "method-disease-data" axis.

Although many previous studies have highlighted the advances in prediction models, instruments for pathological and histological diagnosis and treatme...

Targeting mechanisms of change as a path to precision psychotherapy for community settings.

There have been exciting advancements in mechanisms of change research, but most innovations are rarely applied in community settings. Growing depress...

[Anna AI - a voluntary AI tool to complement psychosocial care in oncology].

Psychosocial support in oncology is gaining increasing importance in the comprehensive therapy and care of cancer patients, yet personal assistance re...

Warning: AI chatbots will soon dominate psychotherapy.

Psychotherapy chatbots have attained remarkable fluency, skill and ubiquity - having become the single most frequent reason people use artificial inte...

Leveraging large language models to identify microcounseling skills in psychotherapy transcripts.

Objective: Microcounseling skills are fundamental to effective psychotherapy, yet manual coding is time- and resource-intensive. This study explores t...

Research experience and career factors in relation to mental health problems: Prevalence, risk factors, and machine learning-based predictive estimates.

BACKGROUND: Mental health issues, including depression, anxiety, and insomnia, are increasingly prevalent among university students and graduates, esp...