Infectious Disease

Public Health

Latest AI and machine learning research in public health for healthcare professionals.

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Complex pathways to ceftolozane-tazobactam resistance in clinical Pseudomonas aeruginosa isolates: a genomic epidemiology study

We aimed to conduct a comprehensive genomic analysis of ceftolozane/tazobactam (C/T) resistance mechanisms in Pseudomonas aeruginosa by combining novel institutional data with publicly available sequencing data. We analysed 1,682 P. aeruginosa isolates, comprising 339 isolates from Alfred Hospital (Melbourne, Australia) and 1,343 isolates from six public datasets. All isolates underwent whole-geno...

External Validation of a Machine Learning Model to Predict Postpartum Hemorrhage in a US Northeastern Healthcare System

Postpartum hemorrhage (PPH) is a major cause of maternal morbidity and mortality. Timely prediction may prevent adverse maternal outcomes, and efforts are needed to develop accurate predictive tools. A high-performing machine learning model to predict PPH using data from the US Consortium for Safe Labor (CSL) remains to be widely validated in contemporary clinical settings using electronic health ...

Comparative Analysis of Long COVID and Post-Vaccination Syndrome: A Cross-Sectional Study of Clinical Symptoms and Machine Learning-Based Differentiation

Long COVID is a well-documented post-viral syndrome, while post-vaccination syndrome (PVS) remains poorly characterized. Understanding their similarit...

Human breast cancer is linked to Epstein-Barr virus because it targets stem cells: bioinformatic chromosome correlations

Breast cancer originates from rare “cancer stem cells”. Stem cells are especially susceptible to becoming cancerous because they readily become differ...

Spatial Distribution and Associated Factors Influencing 2024 Measles-Rubella Vaccination Campaign Coverage among Children Aged 9–59 Months in Mainland Tanzania

Globally, measles remains a major cause of child mortality, and rubella is the leading cause of birth defects among all infectious diseases. In Mainla...

Explainable AI to predict a complex multifactorial outcome, childhood obesity: Application to clinical epidemiology

Childhood obesity, driven by genetic and epidemiological factors, poses significant health risks, yet traditional machine learning models lack interpr...

Temperature dominates dengue transmission in Thailand: Machine learning reveals critical thresholds and COVID-19 disruption

Dengue fever remains a critical public health challenge in Thailand, with transmission dynamics driven by complex interactions between environmental a...

Causal Machine Learning Analysis of All-Cause Mortality in Japanese Atomic-Bomb Survivors

The health consequences of ionizing radiation have long been studied, yet significant uncertainties remain, particularly at low doses. In particular, ...

From Sequences to Strategies: Early Detection of New SARS-CoV-2 Variants via Genetic Distance to Reduce Hospitalizations

The COVID-19 pandemic highlighted the critical need for robust methods to monitor viral evolution and detect emerging variants of concern (VOCs). Trad...

Candidate Correlates of Protection in the HVTN505 HIV-1 Vaccine Efficacy Trial Identified by Positive-Unlabeled Learning

With a goal of unveiling mechanisms by which vaccines can provide protection against HIV-1 acquisition, several studies have explored correlates of ri...

Bayesian hybrid statistical and machine learning models for dengue forecasting in Bangladesh: Temporal and spatial analysis for an early warning system

Dengue remains a major public health concern in Bangladesh, yet reliable forecasting models that integrate climatic and demographic drivers are limite...

Predictive Modelling’s role in Improving Pre-exposure Prophylaxis (PrEP) Uptake in High-Risk HIV Groups in Africa: An Integrative Scoping Review

This scoping review explores how predictive modelling can strengthen pre-exposure prophylaxis (PrEP) uptake among high-risk populations in Africa, whe...

Identifying High-Risk Adolescents for Mental Health Difficulties: A Machine Learning Analysis of the Health Behaviour in School-aged Children Study Across 46 Countries

Adolescent mental health represents a global public health crisis, yet traditional surveillance methods lack the scalability and predictive power need...

Rainfall, Mosquito Indices, and Dengue Outbreaks in Southern Taiwan: Reassessing Predictive Modeling with Machine Learning Approaches

Dengue remains a major public health challenge in southern Taiwan, where recurrent outbreaks are shaped by complex environmental and entomological dri...

Harnessing Machine Learning for Antimicrobial Resistance Surveillance in Zimbabwe

Antimicrobial resistance (AMR) poses a significant public health challenge, particularly in resource-limited settings such as Zimbabwe, where surveill...

Predicting Rejection Risk in Heart Transplantation: An Integrated Clinical–Histopathologic Framework for Personalized Post-Transplant Care

Cardiac allograft rejection (CAR) remains the leading cause of early graft failure after heart transplantation (HT). Current diagnostics, including hi...

Machine Learning-Driven Identification of Serotype-Independent Pneumococcal Vaccine Candidates using samples from Human Infection Challenge Studies

Identifying conserved, immunogenic proteins that confer protection against Streptococcus pneumoniae colonisation could enable development of serotype-...

A Systematic Process for Assessing Fitness-for-Purpose of Health Outcomes for Computable Phenotyping with Electronic Health Record Data

Information from electronic health records (EHRs) may be incorporated into computable phenotype algorithms in efforts to overcome inaccuracies of algo...

BeatAI: BiomEtrics for Atrial Arrhythmia Tracking Using Artificial Intelligence

Postoperative atrial fibrillation (POAF) affects 20 to 50% of patients undergoing cardiac surgery and is associated with longer hospital stays and adv...

First-in-Human Study of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix

Antibodies against the SARS-CoV-2 spike receptor-binding domain provided effective COVID-19 treatment until resistant variants emerged. GB-0669 is a h...

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