Pulmonology

Boosted Multivariate Trees for Longitudinal Data.

Machine learning methods provide a powerful approach for analyzing longitudinal data in which repeated measurements are observed for a subject over time. We boost multivariate trees to fit a novel flexible semi-nonparametric marginal model for longitudinal data. In this model, features are assumed to be nonparametric, while feature-time interactions are modeled semi-nonparametrically utilizing -sp...

Mandibular Reconstruction with Lateral Tibial Bone Graft: An Excellent Option for Oral and Maxillofacial Surgery.

Autogenous bone grafts are the gold standard for reconstruction of atrophic jaws, pseudoarthroses, alveolar clefts, orthognathic surgery, mandibular discontinuity, and augmentation of sinus maxillary. Bone graft can be harvested from iliac bone, calvarium, tibial bone, rib, and intraoral bone. Proximal tibia is a common donor site with few reported problems compared with other sites. The aim of th...

Energy Efficient Monitoring of Metered Dose Inhaler Usage.

Life-long chronic inflammatory diseases of the airways, such as asthma and Chronic Obstructive Pulmonary Disease, are very common worldwide, affecting...

Automatic segmentation of airway tree based on local intensity filter and machine learning technique in 3D chest CT volume.

PURPOSE: Airway segmentation plays an important role in analyzing chest computed tomography (CT) volumes for computerized lung cancer detection, emphy...

The protective effects of bone morphogenetic protein-7 against epithelial injury and matrix metalloproteases upregulation induced by silica in vitro.

OBJECTIVE: We investigate the effects of bone morphogenetic protein-7 (BMP-7) on models with silica-induced and macrophage-mediated fibrosis and its p...

Application of artificial neural network model combined with four biomarkers in auxiliary diagnosis of lung cancer.

The purpose of the study was to explore the application of artificial neural network model in the auxiliary diagnosis of lung cancer and compare the e...

Dysfunction of endothelial progenitor cells in hyperlipidemic rats involves the increase of NADPH oxidase derived reactive oxygen species production.

NADPH oxidase (NOX) is a major source of reactive oxygen species (ROS) in the body and it plays a key role in mediation of oxidative injury in the car...

Developing new VOmax prediction models from maximal, submaximal and questionnaire variables using support vector machines combined with feature selection.

Maximal oxygen uptake (VOmax) is an essential part of health and physical fitness, and refers to the highest rate of oxygen consumption an individual ...

Automatic Diagnosis of Obstructive Sleep Apnea/Hypopnea Events Using Respiratory Signals.

Obstructive sleep apnea is a sleep disorder which may lead to various results. While some studies used real-time systems, there are also numerous stud...

Reliability of Percutaneous Pulmonary Vent and Coronary Sinus Cardioplegia in the Setting of Minimally Invasive Aortic Valve Replacement: A Single-Center Experience.

OBJECTIVES: Evaluating the efficacy of 2 new percutaneous devices specifically designed to be placed through the right internal jugular vein, therefor...

MAG-DPA curbs inflammatory biomarkers and pharmacological reactivity in cytokine-triggered hyperresponsive airway models.

Bronchial inflammation contributes to a sustained elevation of airway hyperresponsiveness (AHR) in asthma. Conversely, omega-3 fatty acid derivatives ...

Predicting early psychiatric readmission with natural language processing of narrative discharge summaries.

The ability to predict psychiatric readmission would facilitate the development of interventions to reduce this risk, a major driver of psychiatric he...

Text mining electronic hospital records to automatically classify admissions against disease: Measuring the impact of linking data sources.

OBJECTIVE: Text and data mining play an important role in obtaining insights from Health and Hospital Information Systems. This paper presents a text ...

Virtual screening of natural compounds as inhibitors of EGFR 696-1022 T790M associated with non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) is the most dominating and lethal type of lung cancer triggering more than 1.3 million deaths per year. The most ef...

Computer-aided diagnosis system for lung nodules based on computed tomography using shape analysis, a genetic algorithm, and SVM.

Lung cancer is the major cause of death among patients with cancer worldwide. This work is intended to develop a methodology for the diagnosis of lung...

Experimental phage therapy against haematogenous multi-drug resistant pneumonia in mice.

BACKGROUND: Community-acquired haematogenous pneumonia is a rare infection, though it can be acquired nosocomially. Currently, antibiotics used again...

Differential association of plasma monocyte chemoattractant protein-1 with systemic inflammatory and airway remodeling biomarkers in type-2 diabetic patients with and without asthma.

BACKGROUND: Chronic inflammation is a hallmark of type-2 diabetes (T2D) and asthma. Monocyte chemoattractant protein (MCP)-1 or CCL-2 is a key regulat...

Multilevel Contextual 3-D CNNs for False Positive Reduction in Pulmonary Nodule Detection.

OBJECTIVE: False positive reduction is one of the most crucial components in an automated pulmonary nodule detection system, which plays an important ...

Artificial Intelligence and Amikacin Exposures Predictive of Outcomes in Multidrug-Resistant Tuberculosis Patients.

Aminoglycosides such as amikacin continue to be part of the backbone of treatment of multidrug-resistant tuberculosis (MDR-TB). We measured amikacin c...

Brief isoflurane anaesthesia affects differential gene expression, gene ontology and gene networks in rat brain.

Much is still unknown about the mechanisms of effects of even brief anaesthesia on the brain and previous studies have simply compared differential ex...