Pulmonology

Latest AI and machine learning research in pulmonology for healthcare professionals.

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Identification of amino acid metabolism-related biomarkers in liver fibrosis: a transcriptomic analysis with experimental validation

Background Liver fibrosis (LF) represents a pivotal pathological phase in the advancement of chronic liver disorders toward cirrhosis. Amino acid metabolism reprogramming plays a pivotal role in its pathogenesis, yet the underlying molecular mechanisms remain incompletely understood. Methods Integrating three public datasets (GSE14323, GSE84044, and GSE136103) with amino acid metabolism-related ge...

Geographical targeting of active case finding for tuberculosis in Pakistan using artificial intelligence software (SPOT-TB): a pragmatic stepped wedge cluster randomized control trial.

Background Community-wide active case-finding (ACF) is being increasingly implemented as a tuberculosis (TB) elimination intervention. However, conventional site selection strategies may result in low yields from screening. We evaluated whether an artificial intelligence (AI) software guided targeting strategy could improve detection of TB during screening activities (called camps) relative to rou...

Computational Design of Novel Selective Phosphodiesterase 4B Inhibitors from Natural Products: An Integrated Machine Learning and Structure-Based Drug Discovery Approach

Abstract Selective inhibition of phosphodiesterase 4B (PDE4B) remains a promising strategy for preserving the anti-inflammatory benefit of PDE4 inhibi...

A Multimodal Neural Network Model for Early Recurrence Prediction in Lung Adenocarcinoma

Lung adenocarcinoma (LUAD), a subtype of non-small cell lung cancer (NSCLC), is the most common primary lung cancer worldwide. Despite advancements in...

Interpretable Predictive Modeling for Medical Data Using Boolean Rule-aware Regression

Purpose: In clinical practice, accurate prediction of disease risk must be accompanied by transparent, human-understandable explanations to support di...

Domain Incremental Learning for Pandemic-Resilient Chest X-Ray Analysis

Deep learning models achieved high accuracy in pneumonia detection from chest X-rays. However, their generalization across clinical domains remains li...

May 18 2026 2605.17729v1
Estimating Daily Taxon-specific Tree Pollen at a 1-km Resolution in Atlanta, GA from 2020 to 2024

While tree pollen is a major trigger of allergic respiratory conditions and different taxa exhibit varying allergenic potentials, the lack of high-res...

Risk of apnoea-related cardiorespiratory instability in preterm infants is modulated by clinical, demographic and dynamic indicators

Background: Apnoea of prematurity is common and may cause desaturation and/or bradycardia. There is marked variability in infants cardiorespiratory re...

Identification of non-covalent inhibitors for the atypical peroxiredoxin PRDX5 as a therapeutic strategy in malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) is an aggressive asbestos-linked cancer with limited therapeutic options and a dismal 5-year survival rate of ~5%...

A multi-omic, spatial, and whole-slide image dataset of lung neuroendocrine tumours from the lungNENomics cohort

Lung neuroendocrine tumours (lung NETs) are rare neoplasms comprising approximately 2% of lung cancers. Recent studies have identified distinct molecu...

Pathogen-specific host responses define distinct pneumonia endotypes in the human lung

Pneumonia is the leading cause of death from infectious disease worldwide. The diagnosis and treatment of patients with pneumonia lag behind other maj...

Integration of immunomonitoring assays with PET/CT in TB patients identifies on-treatment biomarkers

Tuberculosis (TB) continues to pose a significant global public health challenge with substantial morbidity and mortality. Current TB biomarkers lack ...

Contactless ultrasound chest vibration mapping discriminates respiratory and cardiac patients from healthy individuals.

Contactless assessment of cardiopulmonary function remains an unmet need, with current approaches relying either on subjective clinical examination or...

Estimation of Physiological Metrics from Resting ECGs Using Deep Learning in the UK Biobank, Including submaximal exercise derived VO2max, Body Fat Percentage, and Grip Strength

Maximal oxygen consumption VO2max is the gold standard for cardiorespiratory fitness but requires resource-intensive physical testing. Recent reports ...

Uncovering Latent Pathological Signatures in Pulmonary CT via Cross-Window Knowledge Distillation

Multi-window CT imaging captures complementary pathological information across anatomical structures of differing densities, yet existing deep learnin...

May 12 2026 2605.12562v1
BronchoLumen: Analysis of recent YOLO-based architectures for real-time bronchial orifice detection in video bronchoscopy

Bronchoscopy is routinely conducted in pulmonary clinics and intensive care units, but navigating the complex branching of the respiratory tract remai...

May 12 2026 2605.11748v1
DiffSegLung: Diffusion Radiomic Distillation for Unsupervised Lung Pathology Segmentation

Unsupervised segmentation of pulmonary pathologies in CT remains an open challenge due to the absence of annotated multi pathology cohorts and the fai...

May 12 2026 2605.11758v1
M3Net: A Macro-to-Meso-to-Micro Clinical-inspired Hierarchical 3D Network for Pulmonary Nodule Classification

The accurate classification of benign and malignant pulmonary nodules in CT scans is critical for early lung cancer screening, yet remains challenging...

May 12 2026 2605.12570v1
iTRIALSPACE: Programmable Virtual Lesion Trials for Controlled Evaluation of Lung CT Models

We introduce iTRIALSPACE, a programmable evaluation framework for controlled assessment of lung CT models. Standard benchmarks are static retrospectiv...

May 7 2026 2605.05761v1
Eliciting associations between clinical variables from LLMs via comparison questions across populations

The training data of large language models (LLMs) comprises a wide range of biomedical literature, reflecting data from many different patient populat...

May 7 2026 2605.06335v1
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