Rheumatology

Rheumatoid Arthritis

Latest AI and machine learning research in rheumatoid arthritis for healthcare professionals.

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USING ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING APPROACHES TO ENHANCE CANCER THERAPY AND DRUG DISCOVERY: A NARRATIVE REVIEW.

BACKGROUND: This paper looks at how AI and machine learning have been applied over the last ten years to the development of anti-cancer drugs. By speeding up the synthesis of more desirable compounds and the identification of new ones, artificial intelligence (AI) has demonstrated substantial contributions to the research and therapy of anti-cancer therapies.

Jan 1 2024 39585283

Inhibition of choline kinase as an antiamoebic approach in Entamoeba histolytica infection.

Entamoeba histolytica is the parasite responsible for amoebiasis, which can result in amoebic colitis or amoebic liver abscess. Metronidazole has been the conventional treatment for intestinal amoebiasis, but concerns regarding resistance have emerged due to the identification of resistance pathways in E. histolytica. This study investigates a novel anti-amoebic approach targeting the CDP-choline ...

Dec 1 2023 38308830
Elettaria cardamomum essential oil; immunomodulatory, antioxidant, and anti-inflammatory effects for controlling acute Toxoplasma gondii infection.

The present study was conducted to investigate the immunomodulatory and anti-inflammatory effects of Elettaria cardamomum essential oil (ECEO) for the...

Dec 1 2023 38308833
IgE anti-BP180 NC16A autoantibody in both serum and blister fluid samples does not correlate with disease activity of bullous pemphigoid.

The correlation between IgE anti-BP180 NC16A autoantibody and disease activity of bullous pemphigoid (BP) remains disputable. To determine the levels ...

Dec 1 2023 38465539
[Experimental study of APB-DOCK8 transgenic tomato vaccine for caries prevention].

PURPOSE: To observe the anti-caries effect of transgenic tomato anti-caries vaccine after immunization with SD rats by gavage and to explore its immun...

Dec 1 2023 38494961
Biological activities of crude leaf extract and fractions of Scutellaria sibthorpii (Benth.) Halácsy: An endemic plant of North-Cyprus.

Scutellaria sibthorpii is used in treatment of bacterial infections, pains and inflammations. The leaf was extracted by maceration and then partitione...

Nov 1 2023 38264889
Moringa oleifera-mediated iron oxide nanoparticles, characterization and their anti-proliferative potential on MDA-MB 231 human breast cancer cells.

Iron oxide nanoparticles (FeO NPs) stabilized with Moringa oleifera (M.O.) were successfully synthesized. The study aimed to explore the cytotoxic, an...

Nov 1 2023 38264893
DOES GALLIC ACID HAVE A POTENTIAL REMEDIAL EFFECT IN EXPERIMENTAL CORROSIVE BURN INJURY TO THE ESOPHAGUS?

Gallic acid, acting as an antioxidant, anti-precipitant and cytoprotective agent, was used as a possible remedial natural component for treating exper...

Nov 1 2023 39310681
DETERMINATION OF THE PRA POSITIVITY PERCENTAGE IN MALE PATIENTS WITH CHRONIC KIDNEY DISEASE BY USING FLOW CYTOMETRY TECHNIQUE.

The antibodies directed against human leukocyte antigen (HLA) molecules, which play a crucial role in allograft histocompatibility, are called anti-HL...

Aug 1 2023 38549598
DDMut: predicting effects of mutations on protein stability using deep learning.

Understanding the effects of mutations on protein stability is crucial for variant interpretation and prioritisation, protein engineering, and biotech...

Jul 5 2023 37283042
AcrNET: predicting anti-CRISPR with deep learning.

MOTIVATION: As an important group of proteins discovered in phages, anti-CRISPR inhibits the activity of the immune system of bacteria (i.e. CRISPR-Ca...

May 4 2023 37084259
AgeAnno: a knowledgebase of single-cell annotation of aging in human.

Aging is a complex process that accompanied by molecular and cellular alterations. The identification of tissue-/cell type-specific biomarkers of agin...

Jan 6 2023 36200838
In vitro investigation of monoglycerides and zinc glycinate: anti-inflammatory and epithelial barrier function.

The objectives of this study were to investigate the in vitro immune-modulatory effects of monoglycerides and zinc glycinate with porcine alveolar mac...

Jan 3 2023 39657118
Exploring Anti-osteoporosis Medicinal Herbs using Cheminformatics and Deep Learning Approaches.

BACKGROUND: Osteoporosis is a prevalent disease for the aged population. Chinese herbderived natural compounds have anti-osteoporosis effects. Due to ...

Jan 1 2023 36065918
Prescreening in oncology trials using medical records. Natural language processing applied on lung cancer multidisciplinary team meeting reports.

Defining profiles of patients that could benefit from relevant anti-cancer treatments is essential. An increasing number of specific criteria are nece...

Jan 1 2023 36964666
In Vitro Antiviral Activity of a New Indol-3-carboxylic Acid Derivative Against SARS-CoV-2.

The coronavirus disease (COVID-19) pandemic has brought into sharp relief the threat posed by coronaviruses and laid the foundation for a fundamental ...

Jan 1 2023 38234608
Recent Trends in Computer-aided Drug Design for Anti-cancer Drug Discovery.

Cancer is considered one of the deadliest diseases globally, and continuous research is being carried out to find novel potential therapies for myriad...

Jan 1 2023 38031798
Anti-noise computational imaging using unsupervised deep learning.

Computational imaging enables spatial information retrieval of objects with the use of single-pixel detectors. By combining measurements and computati...

Nov 7 2022 36366653
Identifying multi-functional bioactive peptide functions using multi-label deep learning.

The bioactive peptide has wide functions, such as lowering blood glucose levels and reducing inflammation. Meanwhile, computational methods such as ma...

Jan 17 2022 34651655
Computational anti-COVID-19 drug design: progress and challenges.

Vaccines have made gratifying progress in preventing the 2019 coronavirus disease (COVID-19) pandemic. However, the emergence of variants, especially ...

Jan 17 2022 34850817
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