Rheumatology

Stratification of immunotherapy responses by adaptive immune receptor repertoires.

A growing number of diseases are now treated with immunotherapies, which consist of interventions that suppress or stimulate the patient's immune system. Because individual humans express a unique repertoire of adaptive immune receptors, the efficacy of immunotherapies typically varies from person to person. Next generation sequencing of adaptive immune receptor repertoires, combined with machine ...

Translational and real-world evidence of trastuzumab biosimilar CT-P6 plus pertuzumab in neoadjuvant HER2-positive early breast cancer.

BACKGROUND: Data on neoadjuvant treatment with trastuzumab biosimilars, particularly CT-P6, in combination with pertuzumab, are limited. This study evaluates the efficacy, tolerability, and immunogenicity of CT-P6 plus pertuzumab and chemotherapy, in routine clinical practice for HER2-positive early breast cancer, including translational biomarker analyses related to pathologic complete response (...

Efficient AI-driven allegation screening: A case study of Thailand's National Anti-Corruption Commission.

Efficient screening of corruption allegations is crucial for promoting accountability and transparency in public administration. However, many institu...

Morphometric analysis and its application in lupus nephritis: a systematic review.

Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE), characterized by marked histological heterogeneity and high inte...

Integrated multi-omics analysis of prognostic model and immune microenvironment in intrahepatic cholangiocarcinoma.

BACKGROUND: Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy originating from the epithelial lining of second-order bile ducts. Desp...

Deciphering the molecular landscape of Sjögren's disease, mucosa-associated lymphoid tissue lymphoma, and thyroid cancer: unraveling the complexities of disease mechanisms and diagnostic biomarkers.

BACKGROUND: Sjögren's disease (SjD), mucosa-associated lymphoid tissue lymphoma (MALT lymphoma), and thyroid cancer (THCA) are clinically distinct yet...

Budget Impact of Faricimab in Neovascular Age-Related Macular Degeneration in the Netherlands: A Systematic Review and Meta-Analysis of Injection Count.

INTRODUCTION: Frequent anti-vascular endothelial growth factor (anti-VEGF) injections for the treatment of neovascular age-related macular degeneratio...

Artificial intelligence based prediction of first recurrence in neovascular age related macular degeneration with validation by 19 experts.

This study aimed to investigate the value and difference in predictive performance between ophthalmologists and a previously developed and validated a...

Integrative Bioinformatics and Machine Learning Identify Novel Diagnostic Biomarkers and Molecular Mechanisms in Sjögren's Syndrome.

BACKGROUND: Sjögren's syndrome (SS) is a chronic autoimmune disorder characterized by significant diagnostic challenges due to nonspecific symptoms an...

Lymph Node Metastasis-Associated Spatiotemporal Mapping of the TFF3-Linked Niche in Breast Cancer: Integrating Radiogenomic Signatures with Immune-Ecosystem Remodeling.

Primary breast cancer (PBC) with axillary lymph node metastasis (ALNM+) is associated with distinct clinical outcomes, including reduced survival (The...

Machine learning and multi-omics integration identifies immunological predictors and mechanistic insights in autoimmune encephalitis.

OBJECTIVE: To develop an interpretable prognostic prediction model for autoimmune encephalitis (AE) using immunological indicators and to investigate ...

A research on applying the diffusion model algorithm for Infrared and Raman spectroscopy data augmentation to improve the accuracy of diseases.

In recent years, Raman and Infrared spectroscopy have become important tools in disease diagnosis due to their high sensitivity and non-invasive detec...

Machine learning-based identification of factors associated with spontaneous abortion in patients with Systemic lupus erythematosus (SLE): Insights from the Egyptian College of Rheumatology (ECR)-SLE cohort.

BackgroundSystemic lupus erythematosus (SLE), an autoimmune disease, predominantly affects women and is associated with an increased risk of spontaneo...

An old disease, a new linguistic challenge for large language models: patient education on psoriasis and psoriatic arthritis in an underrepresented medical language.

OBJECTIVE: Large Language Models (LLMs) are increasingly applied to patient education, yet their performance in languages that are relatively underrep...

Reconnecting new tetrahydrobenzothieno-4-pyrimidine amides as potent PIM-1 kinase inhibitors via an integrated ligand, machine learning model and structure based scaffold hopping: In vitro anti-tumor investigations.

PIM1 has been known to be one of the prolific molecular target in the discovery of new potential anticancer drugs due to its engagement in activation ...

Markers predicting lymphoma development in Sjögren disease: current status and future perspectives.

We aim to present recent advancements in predictive markers for lymphomagenesis in SjD, concisely organize existing knowledge, and identify correspond...

Machine learning reveals sex-biased platelet-associated molecular signatures in systemic lupus erythematosus.

OBJECTIVES: Autoimmune diseases (ADs) demonstrate a higher prevalence in women than men. Systemic Lupus Erythematosus (SLE) stands out among multiple ...

Identification and validation of key autophagy-related genes in Lupus nephritis.

OBJECTIVES: Lupus nephritis (LN) is one of the most common complications of systemic lupus erythematosus. This study aimed to identify key autophagy-r...

Aucklandia lappa, Vladimiria souliei, and Inula helenium: A comprehensive review on the ethnomedicines, phytochemicals, quality control and pharmacology of three confusable Muxiang varieties (2015-2025).

ETHNOPHARMACOLOGICAL RELEVANCE: The dried roots of Aucklandia lappa (Mu-Xiang), Vladimiria souliei (Chuan-Mu-Xiang), and Inula helenium (Tu-Mu-Xiang),...

Leveraging Interpretable AI for Deciphering Signature Histopathologic Patterns.

BACKGROUND: Leukocytoclastic vasculitis (LCV) and microvascular occlusion (MVO) are distinct histopathologic patterns underlying dermatologic diagnose...