Psychiatry

Schizophrenia

Latest AI and machine learning research in schizophrenia for healthcare professionals.

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Automated design and optimization of multitarget schizophrenia drug candidates by deep learning.

Complex neuropsychiatric diseases such as schizophrenia require drugs that can target multiple G protein-coupled receptors (GPCRs) to modulate complex neuropsychiatric functions. Here, we report an automated system comprising a deep recurrent neural network (RNN) and a multitask deep neural network (MTDNN) to design and optimize multitarget antipsychotic drugs. The system has successfully generate...

Jul 12 2020 32711293

A Combined Deep-Learning and Lattice Boltzmann Model for Segmentation of the Hippocampus in MRI.

Segmentation of the hippocampus (HC) in magnetic resonance imaging (MRI) is an essential step for diagnosis and monitoring of several clinical situations such as Alzheimer's disease (AD), schizophrenia and epilepsy. Automatic segmentation of HC structures is challenging due to their small volume, complex shape, low contrast and discontinuous boundaries. The active contour model (ACM) with a statis...

Jun 28 2020 32605230
Machine learning for genetic prediction of psychiatric disorders: a systematic review.

Machine learning methods have been employed to make predictions in psychiatry from genotypes, with the potential to bring improved prediction of outco...

Jun 26 2020 32591634
Computing schizophrenia: ethical challenges for machine learning in psychiatry.

Recent advances in machine learning (ML) promise far-reaching improvements across medical care, not least within psychiatry. While to date no psychiat...

Jun 15 2020 32536358
Identifying psychosis spectrum youth using support vector machines and cerebral blood perfusion as measured by arterial spin labeled fMRI.

Altered cerebral blood flow (CBF), as measured by arterial spin labelling (ASL), has been observed in several psychiatric conditions, but is a general...

Jun 4 2020 32599552
Language as a biomarker for psychosis: A natural language processing approach.

Human ratings of conceptual disorganization, poverty of content, referential cohesion and illogical thinking have been shown to predict psychosis onse...

Jun 1 2020 32499162
Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors.

In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/demographic predictors...

May 29 2020 32469448
Towards a brain-based predictome of mental illness.

Neuroimaging-based approaches have been extensively applied to study mental illness in recent years and have deepened our understanding of both cognit...

May 6 2020 32374075
Factors and predictors of length of stay in offenders diagnosed with schizophrenia - a machine-learning-based approach.

BACKGROUND: Prolonged forensic psychiatric hospitalizations have raised ethical, economic, and clinical concerns. Due to the confounded nature of fact...

May 6 2020 32375740
Neural memory plasticity for medical anomaly detection.

In the domain of machine learning, Neural Memory Networks (NMNs) have recently achieved impressive results in a variety of application areas including...

Apr 18 2020 32334342
Prediction of physical violence in schizophrenia with machine learning algorithms.

Patients with schizophrenia have been shown to have an increased risk for physical violence. While certain features have been identified as risk facto...

Apr 13 2020 32361562
Multivariate patterns of EEG microstate parameters and their role in the discrimination of patients with schizophrenia from healthy controls.

Quasi-stable electrical fields in the EEG, called microstates carry information on the dynamics of large scale brain networks. Using machine learning ...

Apr 6 2020 32315875
Detecting Abnormal Brain Regions in Schizophrenia Using Structural MRI via Machine Learning.

Utilizing neuroimaging and machine learning (ML) to differentiate schizophrenia (SZ) patients from normal controls (NCs) and for detecting abnormal br...

Apr 5 2020 32300361
Dynamic ElecTronic hEalth reCord deTection (DETECT) of individuals at risk of a first episode of psychosis: a case-control development and validation study.

BACKGROUND: Many individuals who will experience a first episode of psychosis (FEP) are not detected before occurrence, limiting the effect of prevent...

Mar 26 2020 33328055
Feature optimization method for machine learning-based diagnosis of schizophrenia using magnetoencephalography.

BACKGROUND: When many features and a small number of clinical data exist, previous studies have used a few top-ranked features from the Fisher's discr...

Mar 19 2020 32201352
Pragmatics, Theory of Mind and executive functions in schizophrenia: Disentangling the puzzle using machine learning.

OBJECTIVE: Schizophrenia is associated with a severe impairment in the communicative-pragmatic domain. Recent research has tried to disentangle the re...

Mar 3 2020 32126068
Diagnosing schizophrenia with network analysis and a machine learning method.

OBJECTIVE: Schizophrenia is a chronic and debilitating neuropsychiatric disorder. It has been suggested that impaired brain connectivity underlies the...

Feb 5 2020 32022360
Development and Validation of a Machine Learning Individualized Treatment Rule in First-Episode Schizophrenia.

IMPORTANCE: Little guidance exists to date on how to select antipsychotic medications for patients with first-episode schizophrenia.

Feb 5 2020 32083693
A Multidimensional Neural Maturation Index Reveals Reproducible Developmental Patterns in Children and Adolescents.

Adolescence is a time of extensive neural restructuring, leaving one susceptible to atypical development. Although neural maturation in humans can be ...

Jan 2 2020 31896669
Predicting the individual risk of psychosis conversion in at-risk mental state (ARMS): a multivariate model reveals the influence of nonpsychotic prodromal symptoms.

To improve the prediction of the individual risk of conversion to psychosis in UHR subjects, by considering all CAARMS' symptoms at first presentation...

Dec 23 2019 31872289
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