Sepsis

Roles for globus pallidus externa revealed in a computational model of action selection in the basal ganglia.

The basal ganglia are considered vital to action selection - a hypothesis supported by several biologically plausible computational models. Of the several subnuclei of the basal ganglia, the globus pallidus externa (GPe) has been thought of largely as a relay nucleus, and its intrinsic connectivity has not been incorporated in significant detail, in any model thus far. Here, we incorporate newly r...

Minimally invasive, robot-assisted procedure for kidney transplantation among morbidly obese: Positive outcomes at 5 years post-transplant.

The pre-transplant weight loss required of end-stage renal disease patients is often unachievable. Though robot-assisted procedures among extremely obese have shown minimal complication, long-term outcomes are understudied. Previously, we reported no difference in 6-month patient and graft survival among 28 robot-assisted transplant cases (2009-2013) and 28 open controls (2004-2010). Groups were f...

Analysis of platelet-activating factors in severe sepsis by flow cytometry and its correlation with clinical sepsis scoring system: A pilot study.

BACKGROUND: Sepsis is a major global healthcare concern. Platelets and leucocytes play a key role in sepsis. Whole blood flow cytometry (FCM) is a pow...

Using machine learning to guide targeted and locally-tailored empiric antibiotic prescribing in a children's hospital in Cambodia.

: Early and appropriate empiric antibiotic treatment of patients suspected of having sepsis is associated with reduced mortality. The increasing preva...

Changes of Early Sepsis Biomarker Presepsin Level during Hemodialysis: Influence of β-Microglobulin Clearance of Dialysis Membrane: A Preliminary Study.

BACKGROUND: Although presepsin (P-SEP) is an early sepsis biomarker, sepsis is often suspected after starting hemodialysis (HD). To enhance the utilit...

Diagnosis of urinary tract infection based on artificial intelligence methods.

BACKGROUND AND OBJECTIVE: Urinary tract infection (UTI) is a common disease affecting the vast majority of people. UTI involves a simple infection cau...

Critically Ill Recipients of Weight-Based Fluconazole Meeting Drug-Induced Liver Injury Network Criteria.

Fluconazole-associated liver injury is estimated to occur in <10% of patients; however, effect of weight-based fluconazole dosing on liver injury is ...

A machine learning-based model for 1-year mortality prediction in patients admitted to an Intensive Care Unit with a diagnosis of sepsis.

INTRODUCTION: Sepsis is associated to a high mortality rate, and its severity must be evaluated quickly. The severity of illness scores used are inten...

Implementation of deep neural networks to count dopamine neurons in substantia nigra.

Unbiased estimates of neuron numbers within substantia nigra are crucial for experimental Parkinson's disease models and gene-function studies. Unbias...

Comparison of the Abbott Architect BRAHMS and the Biomérieux Vidas BRAHMS Procalcitonin Assays.

BACKGROUND: Procalcitonin (PCT) is a well-established marker for bacterial infection. Recently the US Food and Drug Administration approved the expand...

Experimental infection of Friesian bulls with Theileria orientalis (Ikeda) and effects on the haematocrit, live weight, rectal temperature and activity.

Since 2012, New Zealand has suffered from an epidemic of infectious bovine anaemia associated with T. orientalis (Ikeda), an obligate intracellular pr...

Association of Helicobacter pylori Infection With Colon Cancer and Adenomatous Polyps.

BACKGROUND AND OBJECTIVE: infection is one of the most common chronic bacterial infections in the world, especially in the developing countries. This...

Annual Research Review: Developmental computational psychiatry.

Most psychiatric disorders emerge during childhood and adolescence. This is also a period that coincides with the brain undergoing substantial growth ...

Preparation, characterization, and antibacterial activity of diclofenac-loaded chitosan nanoparticles.

Emerging antibiotic resistance necessitates the development of new therapeutic approaches. Many studies have reported the antimicrobial activity of di...

Spectral Identification of Disease in Weeds Using Multilayer Perceptron with Automatic Relevance Determination.

, a smut fungus, is studied as an agent for the biological control of (milk thistle) weed. Confirmation of the systemic infection is essential in ord...

Plasma and cerebrospinal fluid population pharmacokinetic modeling and simulation of meropenem after intravenous and intrathecal administration in postoperative neurosurgical patients.

Combined intravenous and local intrathecal administration of meropenem in patients after craniotomy is widely used to treat intracranial infections. H...

A Rapid Bacteriophage DNA Extraction Method.

Bacteriophages (phages) are intensely investigated as non-antibiotic alternatives to circumvent antibiotic resistance development as well as last reso...

Molecular Genotyping of Species Isolated from Patients in Tehran, Iran, by Repetitive Element PCR Fingerprinting.

BACKGROUND & OBJECTIVE: is an opportunistic pathogen with high pathogenic and antibiotic-resistance potential and is also considered as one of the ma...

Using preference learning for detecting inconsistencies in clinical practice guidelines: Methods and application to antibiotherapy.

Clinical practice guidelines provide evidence-based recommendations. However, many problems are reported, such as contradictions and inconsistencies. ...

[Expert systems-urgently needed for early diagnosis of sepsis : Results of retrospective clinical validation of the expert system FLORIDA].

The expert system FLORIDA (Fuzzy Logic Orientated Rule Interpreter for Diagnostic Applications) is equipped with a knowledge base applying linguistic ...