Skin Cancer

RNA splicing in health and disease.

RNA splicing expands the functional output of eukaryotic genomes by enabling individual precursor messenger RNA (pre-mRNA) to generate multiple mature transcripts with protein‑coding and regulatory properties. Its fidelity and plasticity depend on coordinated interactions among the spliceosome, trans-acting splicing factors, cis-regulatory elements, and chromatin- and RNA-associated regulatory mec...

Equity in Neurotoxicity Care in the Era of Cancer Immunotherapy.

Immunotherapies such as chimeric antigen receptor T cell (CAR-T) therapy and immune checkpoint inhibitors have improved cancer survival but are associated with potentially severe neurotoxicities that can impair neurologic function, quality of life, and survival. Despite their growing use, substantial disparities persist in the recognition, diagnosis, and management of cancer therapy-related neurot...

The role of artificial intelligence in predicting immunotherapy treatment outcomes based on gut microbiota composition in cancer patients: a meta-analysis.

BACKGROUND: Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, but response varies across patients. Gut microbiota may influence i...

[Reflections on surgical management strategies for locally advanced gastric cancer after neoadjuvant immunotherapy].

Neoadjuvant immunotherapy is reshaping the treatment landscape of locally advanced gastric cancer (GC). The central clinical challenge has expanded fr...

Applications of synthetic biology in biomedicine.

Based on the principles of engineering reconstruction and programmable design, synthetic biology is driving a paradigm shift in biomedical diagnosis a...

Nanotechnology-based immunotherapy: integrating Artificial Intelligence (AI) with current strategies in combating brain cancer disease.

Brain cancer is one of the most challenging malignancies and a major contributor to worldwide morbidity and mortality. Glioblastoma, the most aggressi...

Prognostic value of body composition analysis in cancer patients treated with immunotherapy: a systematic evaluation of TotalSegmentator-based biomarkers.

PURPOSE: Body composition parameters offer objective, imaging-derived prognostic biomarkers, valuable in the context of oncological diseases. This stu...

Laboratory Medicine in Immune Checkpoint Inhibitor-Induced Autoimmune Disorders: Baseline Assessment, Diagnostic Algorithms, Monitoring, and Predictive Biomarkers.

Immune checkpoint inhibitors (ICIs) have substantially improved clinical outcomes across multiple malignancies, but they can disrupt self-tolerance an...

Cost-Effectiveness of an Artificial Intelligence as a Medical Device (AIaMD) for Triaging Patients Presenting to Primary Care with Concerns that They Have a Skin Cancer: A Modelling Study.

INTRODUCTION: Health services are struggling to cope with the growing numbers of people coming with skin lesions they are worried could be cancer. Usi...

SPCC: Inferring Spatial Cell-Cell Interaction by Integrating Single-cell and Spatial Transcriptomics.

Study of single-cell spatial biology reveals the importance of integrating single-cell and spatial data for capturing spatial structure at individual ...

Radiotherapy and immunotherapy in cancer treatment: mechanisms of clinical synergy.

Synergizing radiotherapy (RT) with immune checkpoint inhibitors has emerged as a promising strategy for solid tumors. RT acts as a potent immunomodula...

Integration of single-cell transcriptomics and genomic mutation analysis identifies an immunotherapy-resistant tumor subcluster and validates ARNTL2 as a malignant driver in lung adenocarcinoma.

BACKGROUND: Immunotherapy resistance in lung adenocarcinoma (LUAD) remains a critical clinical challenge, and the mechanisms underlying resistance-ass...

Radiomics for Prediction of Microsatellite Instability Status in Gastric Cancer: A Systematic Review and Meta-Analysis.

BACKGROUND: Microsatellite instability (MSI) is a key biomarker for immunotherapy in gastric cancer (GC), but preoperative non-invasive prediction rem...

PET/CT In paediatric lymphoma: Current role and advances.

Fluorine-18 fluorodeoxyglucose ([18F] FDG) PET/CT has become central to the management of paediatric lymphoma, providing critical information for stag...

AI Simplification of Dermatopathology Reports for Patients: Basic Versus Prompt-Engineered Approaches.

BACKGROUND: Patients struggle to comprehend dermatopathology reports. As artificial intelligence (AI) tools become more accessible, patients may use t...

Modeling microbiome modulation of tumor metabolic networks to predict synergistic therapies.

Differences in microbiome composition profoundly influence drug response, yet methods to model the metabolic impact of microbes on host cells and ther...

AI-driven dual-task prediction model for co-stratifying efficacy and toxicity in NSCLC immunotherapy.

While effective against non-small cell lung cancer (NSCLC), PD-1 inhibitors can induce immune-related adverse events (irAEs), occurring in up to 15.2%...

Cancer immunotherapy under immune pressure: Mechanisms of resistance and the shift toward precision immune engineering.

Cancer immunotherapy has transformed the treatment landscape across multiple malignancies; however, durable responses remain limited to a subset of pa...

Biomarkers of nivolumab benefit in resectable non-small cell lung cancer.

Perioperative nivolumab significantly improved event-free survival (EFS) compared with placebo in patients with resectable non-small cell lung cancer ...

Single-Atom Nanozymes for High-Efficiency Cancer Immunotherapy by Targeting Tumor Microenvironment.

Tumor immunotherapy has emerged as a transformative strategy for cancer treatment. However, its clinical efficacy remains limited by the immunosuppres...