Oncology/Hematology

Skin Cancer

Latest AI and machine learning research in skin cancer for healthcare professionals.

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MDSkin-Net: Multi-Task Skin Lesion Analysis Driven by Pattern Analysis Priors and Spatial Alignment Regularization

Reliable skin lesion segmentation and classification are central to dermoscopic computer-aided diagn...

Predicting Mutational Signature Exposures from H&E Whole Slide Images: A Pan-Cancer Feasibility Study

Mutational signatures reveal cancer-driving processes with clinical relevance: MMR-deficient tumors ...

Septin inhibitors exert opposing effects on distinct higher-order septin structures in melanoma cells

Septins are cytoskeletal GTPases that assemble into diverse higher-order structures with context-dep...

Deep Learning-based Modeling Enhances Efficacy of Natural Ligand CAR Binders Targeting CD70

CD70 is well-recognized as a promising "pan-cancer: chimeric antigen receptor (CAR) T-cell target. P...

A Comparative Evaluation of Pre-trained Convolutional Neural Networks for Melanoma Detection

Early diagnosis of melanoma is critical for improving patient survival rates. However, accurately di...

Skin Cancer Classification Using Explainable Artificial Intelligence With an Ensemble Model and Rigorous Leakage Free Validation

Background: Reliable melanoma classification requires models that capture both local dermoscopic mor...

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Macrophage signature-based prediction of cancer treatment response using MIL-attention

Predicting immunotherapy response from single-cell data remains difficult due to patient-level label...

Accurate detection of metagenomic strain-level associations using average nucleotide identity with StrainSpy

Genetic variation among microbial strains of the same species can profoundly influence their phenoty...

Surprisal-based large language models reveal immunologic insights in lobular breast cancer

In large data sets discovery is often limited to pre-conceived hypotheses and data fishing. Here we ...

A Multi-stage Precision Stratification (MPS) Framework for Navigating Adjuvant Immunotherapy in Hepatocellular Carcinoma After Resection

BackgroundRecurrence rates following curative resection for hepatocellular carcinoma (HCC) remain pe...

PanoraOnc: A pan-cancer clinico-genomic AI model for transferable outcome predictions

Progress in precision oncology, including biomarker discovery and individualized treatment selection...

A Generative Virtual Tissue Model Enables Computational Design of Therapeutic Perturbation Strategies

Computational design has transformed many fields of engineering, where simulators can explore millio...

Humanized Anti-PD-1 Antibodies Generated Using The Conditional Kernel-Elastic Autoencoder

The human immune system excels at generating highly effective antibodies through natural selection a...

Variantscape: Large Language Model-Driven Mining of Biomedical Literature for Clinical Interpretation of Cancer Variants

Background: Precision oncology relies on accurate interpretation of tumour-detected gene variants, t...

Hearsay: Vision-Language Medical Diagnoses Without an Image

When asked to describe a medical image that was never attached, frontier vision-language models do n...

Ensembles of in silico structures enable T cell peptide-MHC binding prediction

Adaptive immunity relies on T-cell receptor (TCR) recognition of peptides presented by the major his...

Deep learning representations of human Immune Health for precision immunology

The human immune system is composed of [~]30-50 distinct cell types, each of which can exist in diff...

CAR T cell foundation model predicts immunotherapy response

Single-cell transcriptomics resolves CAR T-cell states, yet translating heterogeneous cellular signa...

LATTICE: Graph Self-Supervised Learning for Multimodal Spatial Omics Integration

Spatially resolved omics studies increasingly combine transcriptomic and epigenomic assays, yet down...

Multimodal Empirical Bayes Variational Autoencoders for Joint Longitudinal and Time-to-Event Modeling

Longitudinal tumor measurements, dropout information, and genetic covariates provide complementary i...

Mechanistically informed adaptive dosing for cancer immunotherapy using AI-guided decision making

Optimizing dose and schedule remains a central challenge in oncology drug development, particularly ...

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