STDs

Artificial intelligence-assisted diagnosis and subtype differentiation of infectious keratitis.

BACKGROUND: Infectious keratitis (IK) is a major cause of corneal blindness world-wide, and prompt identification of IK and its etiologic subtype is essential for appropriate management. We developed deep learning (DL) models to detect IK and differentiate common subtypes from slit-lamp photographs. METHODS: In this retrospective study, slit-lamp photographs were collected from patients presenting...

Permeable Proton Transport and Hydrogenation Attained by ONCS-Induced Graphene Nanosheet Film for Neuromorphic Memory Devices.

Traditional von Neumann architecture-based devices are limited by the memory wall, hindering the development of next-generation artificial intelligence. Controlling proton transport to achieve hydrogenation in monolayer graphene resulting in the reversible and controllable nature of their memristive behavior has attracted significant interest for neuromorphic applications. However, multilayer grap...

Machine learning-enabled smartphone CRISPR-Cas12a lateral flow platform for sensitive detection of circulating HPV DNA.

Persistent infection with high-risk human papillomavirus (HPV) is a major cause of cervical cancer, and improved point-of-care (POC) detection is crit...

Integrating QSAR-Machine Learning, Biochemical Assays, and Molecular Dynamics for the Discovery of JAK2 Inhibitors in Cervical Cancer.

Cervical cancer remains a major global health challenge, where dysregulated JAK2 signaling constitutes a key molecular driver. Nevertheless, selective...

Multiparametric MRI-based Deep Learning and Radiomics for Evaluating Lymph Node Metastasis in Early-Stage Cervical Cancer.

Purpose To develop a multiparametric MRI-based radiomics model and deep learning-radiomics (DLR) fusion model for preoperative prediction of lymph nod...

A Triage Model for HR-HPV Positive Women Based on Methylation of Human and HPV Genes.

The aim of this study is to develop a machine learning triage model for HR-HPV positive women based on methylation patterns of human and HPV genes to ...

Clinical Significance of Biomarkers in Oropharyngeal Squamous Cell Carcinoma: Recurrence Prediction and Treatment Response.

BACKGROUND: Oropharyngeal squamous cell carcinoma (OPSCC) accounts for a substantial proportion of head and neck cancers, with a rising incidence larg...

Machine Learning-Enabled Multidimensional Ratiometric Sensor Array for Accurate Discrimination and Quantification of Tetracyclines.

Extensive use of tetracycline antibiotics (TCs) threatens ecosystems and human health, necessitating sensitive and selective analytical monitoring app...

Referenceless Proton Resonance Frequency Thermometry Using Deep Learning with Self-Attention.

Proton resonance frequency (PRF) MR thermometry provides temperature feedback for MR-guided focused ultrasound (FUS), but conventional baseline-refere...

A cross-sectional protocol for experimental tongue high-density surface electromyography to detect and classify radiation-associated hypoglossal neuropathy.

BACKGROUND: Hypoglossal neuropathy is the most common lower cranial neuropathy detected as a delayed sequelae of Human Papillomavirus (HPV) -driven or...

Non-invasive CT-based Deep Learning for Human Papillomavirus Status Prediction in Oropharyngeal Cancer.

RATIONALE AND OBJECTIVES: Human papillomavirus (HPV) status is a critical biomarker for treatment planning and patient management in oropharyngeal can...

Sidelobe suppression of Barker codes via MRH method.

The Barker code is widely used in ultrasonic testing to enhance transmitted energy and achieve high-resolution pulse compression through a matched fil...

Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies.

BACKGROUND: The infection of high-risk human papillomavirus (hr-HPV) and related cervical cancer have greatly threatened women's health. However, the ...

A Multicenter Prospective Study to Develop a Prediction Model for Postherpetic Neuralgia Using Clinical and Laboratory Indicators.

INTRODUCTION: Postherpetic neuralgia (PHN) is the most common and difficult-to-treat complication of herpes zoster (HZ). This complication not only ca...

FDA-authorized oncology artificial intelligence and machine learning devices and their clinical evidence: A cross-sectional analysis.

BACKGROUND: Artificial intelligence (AI) and machine learning (ML) tools are increasingly embedded in cancer care, yet the scope of U.S. Food and Drug...

Prevalence of Lipoprotein(a) Testing in Patients With Atherosclerotic Cardiovascular Disease Within a Large Australian Cardiology Network.

BACKGROUND: Increased lipoprotein(a) (Lp[a]) is a genetically determined causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Histor...

Isolated Nausea and Pretibial Rash in a Returning Traveler: Forme Fruste of Leptospirosis.

Leptospirosis is difficult to diagnose because of protean nonspecific clinical manifestations and the lack of rapid, actionable laboratory testing. A ...

Predicting unconfined compressive strength of geopolymer-stabilized clays using a sector fruit fly-based extreme learning machine.

UNLABELLED: Accurate prediction of the unconfined compressive strength (UCS) of geopolymer-stabilized clayey soil is critical for geotechnical enginee...

The long and winding road: the resilience of cervical cytology as a long-standing laboratory tool to aid the diagnosis of HPV-induced lesions.

BACKGROUND: Despite molecular advancements, cervical cytology remains a resilient and fundamental laboratory tool in the prevention of cervical cancer...

Integrated computational screening of FDA-approved anticancer drugs as novel HPV-16 E6 inhibitors in cervical cancer.