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Stem Cell Research

Latest AI and machine learning research in stem cell research for healthcare professionals.

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Platelets as immune sensors: monitoring immune dynamics and diagnosing disease states across multiple disorders.

BACKGROUND: Beyond their classical roles in haemostasis and thrombosis, platelets have been recognised as active regulators of immune responses. However, whether platelets can function as immune sensors capable of monitoring immune status remains largely unexplored. METHODS: We first analysed platelet transcriptomes from patients at different stages following haematopoietic stem cell transplantati...

Feb 19 2026 41719795

Dual-Parallel Artificial Intelligence Framework for Breast Cancer Grading via High-Intensity Ultrasound and Biomarkers.

BACKGROUND: Accurate and noninvasive breast cancer grading and therapy monitoring remain critical challenges in oncology. Traditional methods often rely on invasive histopathological assessments or imaging-only techniques, which may not fully capture the molecular and morphological intricacies of tumor response. METHOD: This article presents a novel, noninvasive framework for breast cancer analysi...

Feb 19 2026 41027412
Artificial intelligence-driven nano-enhanced stem cell therapy for neurodegenerative diseases: from rational design to clinical translation.

Neurodegenerative diseases (NDs) are progressive and incurable central nervous system disorders characterized by the accumulation of pathological prot...

Feb 19 2026 41709202
Strategies of AI-Driven CAR-T Cell Therapy Towards Solid Tumours.

Chimeric antigen receptor (CAR)-T cell immunotherapy shows significant success in hematologic malignancies. However, it faces critical challenges in s...

Feb 19 2026 41709747
The future of periodontology: Emerging technologies and conceptual shifts.

Periodontology is entering a transformative era driven by advances in diagnostics, therapeutics, and digital integration. Emerging technologies and co...

Feb 19 2026 41711187
CSF proteomics identifies ADGRG1 as a predictive biomarker of intrathecal immune checkpoint inhibitor response in leptomeningeal metastasis.

BACKGROUND: Leptomeningeal metastasis (LM) is a fatal complication of advanced cancer with limited therapeutic options and poor prognosis. Immune chec...

Feb 19 2026 41714114
The value of artificial intelligence combined with multimodal data analysis in tumor immunotherapy and targeted therapy.

The advent of immunotherapy and targeted therapy has revolutionized oncology treatment in recent years, marking a transformative shift toward precisio...

Feb 18 2026 41720277
Artificial Intelligence in African Cardiovascular Care: Opportunities, Challenges, and Pathways to Improved Outcomes.

Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality in Africa, accounting for over 1 million deaths annually. As CVD preva...

Feb 18 2026 41716639
ChatGPT in undergraduate speech and language therapy education: students' perspectives and experiences.

PURPOSE: This study aimed to investigate the perceptions, experiences, and ethical awareness of undergraduate Speech and Language Therapy (SLT) studen...

Feb 18 2026 41709271
Lesion-level dual-tracer PET biomarkers predict prognosis in multiple myeloma treated with CXCR4-directed radiopharmaceutical therapy.

BACKGROUND: C-X-C motif chemokine receptor 4 (CXCR4)-directed radiopharmaceutical therapy (RPT) represents a promising option for hematologic malignan...

Feb 18 2026 41706122
An odyssey of monoclonal gammopathies: focusing on precursors and the progression from MGUS and SMM to multiple Myeloma, with a brief overview of novel therapeutic strategies.

Monoclonal gammopathies span a continuum from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) to overt...

Feb 18 2026 41706224
Pondering the Future of Chemical Research amid the Wider Adoption of Artificial Intelligence Technologies.

The rapid adoption of artificial intelligence (AI) and machine learning (ML) in chemistry coincides with increasing structural pressures on academic r...

Feb 18 2026 41706745
Efficacy and neural mechanisms of a vibrotactile-enhanced, brain-controlled soft robotic glove for upper limb rehabilitation after stroke: a multicentre randomised controlled trial protocol.

INTRODUCTION: Soft robotic gloves (SRGs) integrated with brain-computer interfaces (BCIs) have demonstrated potential in facilitating motor recovery a...

Feb 18 2026 41708167
ESMO adaptation of Lines of Systemic Therapy (EnLiST): a consensus framework for standardising the designation of lines of therapy in solid tumours.

Enumeration of lines of therapy (LoT) is critical across oncology for ensuring optimal patient care, establishing uniform eligibility for clinical tri...

Feb 17 2026 41713786
Single-cell systems network and machine learning dissection of ferroptosis in recurrent glioblastoma highlights astrocytic ZFP36 as a therapeutic hub for network medicine repurposing.

BACKGROUND: Recurrent glioblastoma multiforme (rGBM) arises after conventional treatment strategies for primary GBM (pGBM) fail, leading to a more agg...

Feb 17 2026 41713080
ERBB2 as a Prognostic Biomarker in Prostate Cancer: Integration of Single-Cell Transcriptomics, Deep Learning, and Immunohistochemical Validation.

Biochemical recurrence (BCR) is a critical factor affecting the prognosis of prostate cancer (PCa) patients, while T cell exhaustion and metastatic pr...

Feb 17 2026 41701406
STRATUM-OS: first step in the development and validation of the STRATUM tool based on multimodal data processing to assist surgery in patients affected by intra-axial brain tumours - observational study protocol.

INTRODUCTION: Integrated digital diagnostics can support complex surgeries in many anatomic sites, and brain tumour surgery represents one of the most...

Feb 17 2026 41702662
A machine learning model for optimizing treatment of patients with poorly controlled type 2 diabetes.

BACKGROUND: Cardiorenal-protective sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) lack se...

Feb 17 2026 41703087
The 487-gene expression profile test guides systemic therapy selection to improve outcomes for patients with atopic dermatitis: Results from a prospective trial.

BACKGROUND: Current atopic dermatitis (AD) therapy selection does not account for molecular drivers of disease, contributing to inadequate disease con...

Feb 16 2026 41707702
Advancements and challenges in CAR-NK cell therapy for cancer treatment.

Chimeric antigen receptor natural killer (CAR-NK) cell therapy is an emerging cancer treatment offering advantages over CAR-T therapy, including reduc...

Feb 16 2026 41702798
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