Stem Cell Research

Multimetallic nanostructures: innovations and applications in environmental remediation, biosensing, and medical technologies.

Multimetallic nanostructures (MNs) have emerged as versatile materials with significant potential in various applications, including environmental remediation, biosensing, and medical technologies. Their unique electronic, catalytic, and optical properties make them effective for pollutant removal, sensitive detection of biomarkers, and targeted drug delivery. This article reviews the diverse appl...

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno-Associated Viral Vectors.

Adeno-associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients. Traditional methods for improving viral vector purity are res...

Fuzzy classification of sepsis subtypes and implications for trajectory and treatment.

BACKGROUND: Sepsis is common and deadly, and subtypes are proposed to guide precision treatment. However, little is known about the uncertainty in sub...

Quantum-enhanced throughput pathways: Integrating Rodgers' TPM with quantum ethical frameworks for AI-driven cybersecurity.

This integrative conceptual review synthesizes psychological, ethical, and quantum-information perspectives to advance Quantum-Enhanced Throughput Mod...

Development and validation of an interpretable machine learning model for non-invasive screening of precancerous gastric lesions using symptom and lifestyle data: a multicentre cohort study.

BACKGROUND: Precancerous gastric lesions (PLGC) are a critical stage in gastric cancer progression, where timely intervention can substantially reduce...

Smart Designer Nanozymes for Precision Cancer Therapy: Recent Advances and Prospects.

Nanozymes are enzyme-mimicking nanomaterials that are promising for diverse biomedical applications; they enable stable, tunable, and multifunctional ...

Boosting angiogenesis experimentally in ovo by biofunctionalizing collagen membranes with platelet-rich fibrin and hyaluronic acid: implications for regenerative oral surgery?

PURPOSE: Biocompatible collagen membranes (CM) are widely used in regenerative dentistry, particularly in guided tissue regeneration (GTR) and guided ...

Charting exposomethics: a roadmap for the ethical foundations of the human exposome project.

BACKGROUND: The Human Exposome Project (HEP) aims to chart lifelong environmental exposures and their biological consequences, furnishing the environm...

Single-cell profiling of immunogenic cell death in melanoma reveals prognostic signatures and therapeutic targets.

BACKGROUND: Cutaneous melanoma is one of the most aggressive forms of skin cancer, marked by rapid progression, early metastasis, and high resistance ...

Order-Aware Deep Learning for Drug Combination Benefit Prediction in Cancer Cell Lines.

Drug combination therapy has exhibited favorable effects in treating cancer patients, with less toxicity and adverse reactions compared to monotherapy...

Using Latent Dirichlet Allocation Topic Modeling to Uncover Latent Research Topics and Trends in Renal Cell Carcinoma: Bibliometric Review.

BACKGROUND: Renal cell carcinoma (RCC) is a common, often lethal kidney cancer that originates in the renal cortex. Its incidence is rising, and major...

Core Elements of Goals of Care Initiatives Across Eight Health Systems.

For patients with serious illnesses, goals of care conversations improve quality of life and patient and family satisfaction and may reduce healthcare...

Integrating Artificial Intelligence Into Exposure Therapy: A One Year Follow-Up Case Report of Emetophobia With Comorbid Panic Disorder.

Emetophobia is a specific phobia characterized by an intense fear of vomiting, often accompanied by panic attacks, hypervigilance to bodily sensations...

Preserving scientific integrity in academic publishing: Navigating artificial intelligence, journal policies and the impact factor as a quality indicator.

The integration of artificial intelligence (AI), the rise of mega-journals, and the manipulation of impact factors present challenges to scientific in...

[Responsible use of AI and robotics in medicine : Opportunities, challenges and perspectives for otorhinolaryngology].

Artificial intelligence (AI) and robotics are transforming the foundations of medical practice. Their integration creates new opportunities for precis...

[Surgery in the hospital and the practice : Chances, challenges and perspectives in otorhinolaryngology].

Operative ear, nose and throat (ENT) medicine in Germany is facing a profound structural change, which is significantly influenced by the ongoing hosp...

Reconstruction of Facial Bony Defects Using 3D Printed Polylactic Acid/β-Tricalcium Phosphate Bioimplant.

Reconstruction of facial defects requires highly accurate techniques that utilize modern effective technologies. 3D printing has revolutionized the fi...

Limitations in the Design of Critical Care Studies and Suggestions for Future Research Directions.

Glucocorticoid (GC) therapy has been a cornerstone of critical care; however, its full potential has been constrained by fixed-dose regimens and trial...

[Emphasizing evolution of key technological elements in reconstructive surgery].

Reconstructive surgery is fundamentally dedicated to restoring tissues and organs damaged by trauma, disease, or congenital anomalies, with the goal o...

[Extracellular matrix materials and tissue regeneration and repair].

The extracellular matrix (ECM) plays a pivotal role in regulating cellular behavior and driving tissue regeneration. Its unique structural characteris...