Steroids

Effects of Progesterone and 17β-Estradiol under Presence or Absence of FBS on Plasminogen Activators Activity in Porcine Uterine Epithelial Cells.

The present study was conducted to investigate the regulatory mechanism of plasminogen activators (PAs) activation by 17β-estradiol (E) and progesterone (P) in porcine uterine epithelial cells (pUECs). pUECs were collected from porcine uterine horn and cultured at 80% confluence. Then, 0.1% (v/v) DMSO, 20 ng/mL E, and P with or without fetal bovine serum (FBS) treated to cultured cells for 24 hour...

Adult Idiopathic Renal Fanconi Syndrome: A Case Report.

Renal Fanconi syndrome (RFS) is caused by generalized proximal tubular dysfunction and can be divided into hereditary and acquired form. Adult-onset RFS is usually associated with drug toxicity or systemic disorders, and modern molecular genetics may explain the etiology of previous idiopathic cases of RFS. Here, we report the case of a 52-year-old woman with RFS whose etiology could not be identi...

Development of competitive lateral flow immunoassay coupled with silver enhancement for simple and sensitive salivary cortisol detection.

Cortisol is known as a stress biomarker. The measurement of cortisol levels is an early warning indicator for health conditions and diagnosis of stres...

Retrospective Data Analysis of the Influence of Age and Sex on TPMT Activity and Its Phenotype-Genotype Correlation.

BACKGROUND: Therapeutic efficacy and toxicity of thiopurine drugs (used as anticancer and immunosuppressant agents) are affected by thiopurine S-methy...

Acute Retroviral Syndrome Presenting as Acute Hepatitis.

Acute retroviral syndrome (ARS) can present as a wide array of clinical manifestations. Establishing a diagnosis early in the disease course can provi...

Transcription factor binding site clusters identify target genes with similar tissue-wide expression and buffer against mutations.

The distribution and composition of -regulatory modules composed of transcription factor (TF) binding site (TFBS) clusters in promoters substantially...

Isolated Pulmonary Cryptococcosis Confused with Lung Tumor 5 Years After Kidney Transplantation: A Case Report.

BACKGROUND: In transplant recipients, due to the use of immunosuppressive therapy, it is occasionally difficult to distinguish between an infection an...

Endophthalmitis following cataract surgery and intracameral antibiotic: Moxifloxacin resistant .

PURPOSE: To describe an immunosuppressed patient who developed acute-onset postoperative endophthalmitis caused by a moxifloxacin-resistant strain of ...

A 6 Second Analytical Method for Quantitation of Tacrolimus in Whole Blood by Use of Laser Diode Thermal Desorption Tandem Mass Spectrometry.

BACKGROUND: Therapeutic drug monitoring of immunosuppressive drugs is imperative for organ transplant recipients. High-performance LC-MS/MS is conside...

Insulin resistance and adrenal incidentalomas: A bidirectional relationship.

An adrenal incidentaloma (AI) is an adrenal mass incidentally found via a radiological modality, independent of an endocrinological investigation. In ...

Can low-frequency guided waves at the tibia paired with machine learning differentiate between healthy and osteopenic/osteoporotic subjects? A pilot study.

PURPOSE: Axial transmission quantitative acoustics (ax-QA) has shown to be a promising tool for assessing bone health and properties in a safe, inexpe...

Morphological profiling using machine learning reveals emergent subpopulations of interferon-γ-stimulated mesenchymal stromal cells that predict immunosuppression.

BACKGROUND: Although a preponderance of pre-clinical data demonstrates the immunosuppressive potential of mesenchymal stromal cells (MSCs), significan...

Level of circulating steroid hormones in malaria and cutaneous leishmaniasis: a case control study.

Epidemiological and clinical studies have shown a great difference in the severity and prevalence of infectious diseases in men and women and various ...

Segmentation of the Proximal Femur from MR Images using Deep Convolutional Neural Networks.

Magnetic resonance imaging (MRI) has been proposed as a complimentary method to measure bone quality and assess fracture risk. However, manual segment...

Usefulness of Delayed Introduction of Tacrolimus in Kidney Transplants Using Type-III Donors After Circulatory Death.

INTRODUCTION: Our study compares 2 immunosuppressive strategies to reduce tacrolimus nephrotoxicity and its risk of acute tubular necrosis: delayed in...

Vitamin D status in relation to age, bone mineral density of the spine and femur in obese Saudi females - A hospital-based study.

The aim of the present study was to evaluate the association between Bone mineral density in lumber spine and femoral neck with serum total levels of ...

Artificial Intelligence Applied to Osteoporosis: A Performance Comparison of Machine Learning Algorithms in Predicting Fragility Fractures From MRI Data.

BACKGROUND: A current challenge in osteoporosis is identifying patients at risk of bone fracture.

Effectiveness of bisphosphonate combined with activated vitamin D in patients with aromatase inhibitor-induced osteoporosis after breast cancer operation.

OBJECTIVES: We compared the effectiveness of bisphosphonates combined with activated vitamin D administered for therapy of aromatase inhibitor-induced...

Using Machine Learning to Aid the Interpretation of Urine Steroid Profiles.

BACKGROUND: Urine steroid profiles are used in clinical practice for the diagnosis and monitoring of disorders of steroidogenesis and adrenal patholog...

Estimating risk of severe neonatal morbidity in preterm births under 32 weeks of gestation.

A large recent study analyzed the relationship between multiple factors and neonatal outcome and in preterm births. Study variables included the reas...