Transplantation

Prostate Targeting: Compact Robot With Harmonic Stepper Motors for MRI-Guided Needle Therapy.

The superior image quality and excellent contrast offered by Magnetic Resonance Imaging (MRI) make it an ideal tool for guiding interventional procedures, particularly in targeting tumors within soft tissues. This paper presents an innovative robotic system, tailored for Magnetic Resonance (MR) environments, leveraging the benefits of MRI's high-resolution imaging capabilities for precise tumor ta...

Limitations of the refolding pipeline for de novo protein design.

With the emergence of powerful deep learning-based tools, computational protein design has become a widely accessible technique. Nowadays, it is possible to perform both sequence and structure design in a matter of minutes, making the technology attractive to the broader scientific community. In protein design campaigns, one of the most common in silico strategies to evaluate how well a sequence e...

Combining bioinformatics and machine learning to analyze and validate sepsis-related cell senescence genes and potential drugs.

Sepsis is a life-threatening organ malfunction induced by the host's abnormal reaction to infection. Sepsis can induce cellular senescence, thereby ex...

σ-p Hyperconjugation-Enabled Covalent Organic Frameworks for Programmable Cascaded Optical Modulation.

σ-p hyperconjugation is identified as an effective molecular lever for regulating the excited-state behavior and donor characteristics of covalent org...

Molecular Engineering of the Nano-Bio Interface for Programmable and Precision Protein Delivery.

Protein therapeutics offer unparalleled specificity and immediate bioactivity for addressing complex pathologies; however, their vast therapeutic pote...

Avoiding Monsters: Weighing Recipient Risk and Donor Quality in Lung Transplantation.

Beyond Reactive Surveillance: Can Machine Learning Finally Personalize Heart Transplant Care?

Spatially resolved single cell analysis suggests an APOE NCF1 associated immunosuppressive niche and its prognostic signature in thyroid cancer.

BACKGROUND: Thyroid carcinoma (TC) presents a rising global incidence, with a subset of cases progressing aggressively despite standard therapies. The...

AI-driven text mining of the female reproductive system: enabling multiscale biomedical modeling and personalized medicine.

The female reproductive system, including the endometrium, placenta, ovary, cervix, and fallopian tube, plays a critical role in conception, implantat...

Probiotics and Postbiotics in Life-Style Disease Management: A Comprehensive Review on the Technologies in the Era of Omics and Artificial Intelligence.

Both conventional and next-generation probiotics play a crucial role in maintaining host homeostasis. They modulate insulin sensitivity, immune-regula...

PromptSE: drug side effect prediction with LLM-derived pharmacological representations.

Predicting drug-side effect associations is vital for drug discovery and patient safety. Accurate prediction requires high-quality representations of ...

Organoids as next-generation models for investigating intracranial tumours.

Tumour organoids have emerged as important tools in brain tumour research, addressing long-standing limitations of conventional two-dimensional cultur...

Exosomes in bone health and disease: cellular crosstalk, systemic signaling, and AI-driven advances in regenerative therapy.

Exosomes have emerged as critical mediators of intercellular and inter-organ communication in bone biology. Secreted by bone-resident cells such as os...

Pediatric post-acute sequelae of SARS-CoV-2 infection in Taiwan: Insights from the DISCOVER cohort.

The post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID, represent a multifaceted challenge in pediatric populations, characterized by s...

Bioinformatics analysis identifies biomarkers associated with T-cell depletion in systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems. In SLE, T-cell subsets are closely associated ...

A voltage-controlled reconfigurable memristor with dual-mode synaptic plasticity for adaptive neuromorphic computing and mechanism analysis.

In this study, we propose and experimentally validate a simple planar-integrated dual-device memristor structure based on HfO2/Al2O3heterostructure, w...

TiON/NiOx Heterojunction Neuron for CMOS-Compatible Hardware Implementation of Activation Function in Neural Network.

This study presents a compact neuron device based on a PN heterojunction neuron to enable hardware-level deep neural networks (HDNNs) with improved in...

Validation of an automated AI-based micro-CT organ segmentation workflow against expert annotations and its impact on fluorescence quantification.

OBJECTIVE: Automated, artificial intelligence (AI)-based, organ segmentation has the potential to streamline preclinical imaging workflows, but its su...

From donor lungs to digital twins.

Cyclosporine in hematological disorders: mechanisms, clinical practice and emerging advances.

Cyclosporine A (CsA) functions as a calcineurin inhibitor that perturbs T cell activation via calcineurin-nuclear factor of activated T cells (CaN-NFA...