Transplantation

OracleScreen-LILRB4: machine learning-guided discovery of myeloid immune checkpoint binders validated in patient-derived cells.

The identification of small molecule modulators of immune checkpoint proteins remains a significant challenge in drug discovery due to the flat, featureless nature of protein-protein interaction interfaces and the characteristically low hit rates observed in conventional high-throughput screening campaigns. Here we report OracleScreen-LILRB4, an ensemble machine learning framework trained on quant...

Explainable machine learning identifies small high-performance gene signatures from full transcriptomes in human liver preservation cohorts.

Transcriptomic studies of liver preservation and ischemia-reperfusion injury (IRI) often report large gene lists that are difficult to translate into deployable diagnostic tools. Genome-wide profiling remains impractical within organ procurement timelines, where decisions must be made rapidly and assay infrastructure is limited. A compact, interpretable gene panel deployable via targeted platforms...

Mapping the intellectual landscape of malaria drug repurposing: a systematic analysis of the 51 most cited studies.

BACKGROUND: The escalating threat of Plasmodium falciparum resistance to artemisinin-based therapies necessitates accelerated drug development. Drug r...

Identification of distinct subgroups in Chinese patients with Behçet's syndrome via cluster analysis of immune cells and clinical features.

OBJECTIVES: This study aimed to use machine learning to explore Behçet's syndrome (BS) heterogeneity by integrating immunocyte subpopulations and clin...

Echocardiographic assessment in arterial hypertension: a contemporary narrative review.

Arterial hypertension remains the leading modifiable cause of cardiovascular morbidity and mortality resulting in characteristic changes in cardiac st...

A personalized view on how artificial intelligence will change the future of multidirectional cell therapy: From design and engineering foundation to some healthcare applications.

Artificial intelligence (AI) is becoming a central enabling technology for multidirectional cell therapy, regenerative medicine, and transplantation s...

What's happening? Editorial comment: Insights on artificial intelligence, cell therapy and stem cell transplantation safety.

The functional relevance of human leukocyte antigens in the development of cord blood derived advanced cellular therapies: A new direction of public cord blood banks.

CBUs have been applied as alternative source of HSCs transplantation. The increasing preference for haploidentical HSC transplantation has resulted in...

Development and external validation of an interpretable machine learning model for predicting prolonged postoperative ICU length of stay in coronary artery bypass grafting patients using MIMIC-IV 3.1 and eICU-CRD 2.0.

BACKGROUND: Prolonged postoperative intensive care unit (ICU) length of stay (LOS) after coronary artery bypass grafting (CABG) drives resource use ye...

A dual-contrast deep learning model for automated assessment of sarcopenia using MRI.

PURPOSE: To develop a dual-contrast deep-learning model for automated muscle segmentation on spin-echo and Dixon magnetic resonance imaging (MRI) for ...

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review).

Skeletal muscle functions as an endocrine organ, secreting myokines that mediate interorgan communication with bone. Exercise‑induced myokines regulat...

Genomic scale analysis of assembly-line polyketide synthase diversity and evolution.

Covering: up to 2026Assembly-line polyketide synthases (PKSs) are among the most sophisticated catalysts in nature, responsible for the biosynthesis o...

Multidrug resistance in cancer: current understandings and future perspective.

Multidrug resistance (MDR) remains the core clinical barrier limiting the achievement of durable and effective treatment for various tumors. With the ...

Disulfidptosis-related signatures identify SPARC+/CYR61+ stromal cells mediating immunosuppression in gastric cancer.

BACKGROUND: Disulfidptosis is a novel form of glucose starvation-induced cell death, yet its prognostic implications in gastric cancer (GC) remain lar...

[Point-of-care biomarkers of ocular surface disease: Current approaches and future perspectives].

Dry eye disease is a common multifactorial condition that significantly impairs patients' quality of life. In clinical practice, conventional diagnost...

Ensemble machine learning for predicting flexural capacity of FRCM-strengthened RC beams.

Fabric reinforced cementitious matrix (FRCM) composites are progressively applied to strengthen reinforced concrete (RC) members because they offer im...

Decoding splicing variants in high-throughput sequencing: a functional validation approach integrating deep learning tools.

High-throughput genome and exome sequencing have uncovered numerous intronic variants in disease genes, yet predicting their impact on pre-mRNA splici...

Immunosuppressive regimens and long-term kidney transplant outcomes: A dual survival modeling framework.

Optimizing immunosuppressive therapy remains central to improving long-term outcomes after kidney transplantation. Both induction and maintenance ther...

Integrated single-cell RNA sequencing and Bulk-RNA technologies reveal the immunological characteristics of lactylation related-genes in glioblastoma.

OBJECTIVE: Glioblastoma (GBM) is the most aggressive type of intracranial malignant tumor, known for its extremely poor prognosis. Lactylation, a newl...

Data-driven design of hybrid graphene oxide-MXene polymeric membranes for water purification.

Two-dimensional (2D) materials offer promising platforms for water purification, particularly for challenging oil-in-water emulsions. Here, a hybrid m...