Transplantation

Prognostic prediction models for psoriatic arthritis in psoriasis: A systematic review.

BACKGROUND: Psoriatic arthritis is a chronic inflammatory arthropathy that affects up to 22% of individuals with psoriasis. Identifying patients at higher risk of developing this disease presents a window of opportunity for dermatologists to consider treatments that can limit its progression. OBJECTIVES: This study aims to systematically identify and evaluate the predictive performance, risk of bi...

Engineered small extracellular vesicles in hematologic malignancies: mechanisms, therapeutic strategies, and translational challenges.

Hematologic malignancies remain among the most challenging cancers to treat due to genetic heterogeneity, clonal evolution, and therapy resistance. Extracellular vesicles (EVs), particularly small EV (sEV)-enriched populations, have emerged as active mediators of disease biology, contributing to tumor progression, immune evasion, and chemoresistance through intercellular transfer of bioactive carg...

Stem Cell Therapy for Traumatic Brain Injury: Translational Mechanisms, Biomarkers, and Clinical Trials.

Traumatic brain injury (TBI) is a leading cause of persistent cognitive, motor, and neuropsychiatric impairment, arising from both the initial mechani...

Preclinical Models of Rare Corneal and Ocular Surface Diseases: a Comprehensive Narrative Review.

Rare eye diseases of the cornea and ocular surface (REDs) remain a clinical challenge owing to their low prevalence, heterogeneous presentation, and l...

Multi-Omics Analysis Identifies Paxillin as a Biomarker of Doxorubicin Resistance via Cytoskeletal Remodeling and Immune Exhaustion.

Chemotherapy resistance remains a primary cause of treatment failure in breast cancer, yet the global proteomic landscape driving this phenotype has n...

Assistive communication technologies for individuals with multiple disabilities: an evidence mapping review informing future AI-enabled AAC.

OBJECTIVE: Assistive communication technologies are central to participation for individuals with multiple disabilities. Although artificial intellige...

[Reirradiation: A new therapeutic paradigm in oncology].

Reirradiation (reRT) has become an essential therapeutic option for selected patients with locoregional recurrences, when surgery or systemic therapie...

Effect of chemical treatment on the mechanical and thermal performance of flax fiber reinforced aluminium 6082 laminate: a machine learning-enhanced investigation.

This work examined the role of alkaline and epoxy-based surface chemical treatments on the mechanical and thermal properties of flax fiber reinforced ...

Continuous predictive mortality risk monitoring after allogeneic hematopoietic stem cell transplantation.

Allogeneic hematopoietic stem cell transplantation remains critical for treating high-risk hematological malignancies like leukemia. Despite advances ...

Multifaceted role of histopathology in liver transplantation for hepatocellular carcinoma: A narrative review towards precision prognosis.

Hepatocellular carcinoma is a leading cause of cancer mortality globally. Liver transplantation is considered the best curative treatment for selected...

Immunologic clustering of donor-specific antibodies and clinical outcomes in kidney transplant recipients.

BACKGROUND: Donor-specific antibodies (DSA) against human leukocyte antigens (HLA) are associated with increased immunologic risk in kidney transplant...

Mechanism-Based Multitarget Modeling for Pathway-Level Prediction of PI3K/Akt Signaling Perturbation Induced by Liquid Crystal Monomers.

Liquid crystal monomers (LCMs) are emerging contaminants whose system-level toxicity mechanisms remain poorly understood. Here, we developed a pathway...

From donor to recipient: Interpretable machine learning refocuses the prediction of post-transplant MASLD.

Advances in Biomaterial-Based Cardiac Organoids Engineering for Modeling Development and Congenital Heart Defects.

Human cardiac organoids have emerged as transformative platforms that bridge the gap between reductionist 2D cultures and poorly predictive animal mod...

Embryo transfer in dairy herds: a comprehensive review of factors affecting pregnancy success from donor to embryo and recipient.

Embryo transfer (ET) is a fundamental biotechnology in modern dairy production, utilized to maximize the propagation of superior genetics and circumve...

Machine learning model based on clinical and imaging features for predicting fungal infections in children with leukemia.

BACKGROUND: Due to immunosuppression, mucosal barrier injury, and prolonged neutropenia resulting from both the disease and chemotherapy, along with t...

Medical students' attitudes toward socioscientific issues in female reproductive anatomy teaching: a cross-sectional study.

OBJECTIVES: This study aimed to assess medical students' attitudes toward integrating socioscientific issues (SSI) into female reproductive anatomy te...

Proteomic and machine learning analysis predicts treatment response signatures in Myasthenia Gravis.

BACKGROUND: Myasthenia gravis (MG) is a prototypical antibody-mediated autoimmune disease with variable treatment responses with a need for biomarkers...

Ultra-Broadband Microwave Absorption and Programmable Multispectral Camouflage Enabled by Neural-Network-Driven Impedance-Gradient Metadevices.

Achieving omnidirectional multispectral compatible camouflage remains a significant challenge due to the pronounced disparities in electromagnetic wav...

Explainable machine learning on resting-state magnetoencephalography power spectra reveals neural alterations in knee osteoarthritis.

This study aimed to investigate abnormal patterns of resting-state magnetoencephalography (MEG) power spectra in patients with knee osteoarthritis (KO...