Latest AI and machine learning research in transplantation for healthcare professionals.
Immunotherapy has long played a pivotal role in cancer treatment, and antigen-presenting cell (APC)-based immunotherapy represents a promising strategy, though its full potential remains to be realized. This therapy stimulates T cell activation and proliferation through APCs, producing therapeutic effects. However, the use of natural APCs in immunotherapy faces several limitations, including ineff...
Sequence-controlled polymers, such as polypeptides, offer a versatile platform for tuning the microenvironment of catalytic centers, drawing inspiration from enzymes while enabling a larger design space, structural flexibility, automated synthesis, and compatibility with closed-loop optimization. Here, we designed an artificial oxidase system by immobilizing Fe(III)-protoporphyrin IX onto a lysine...
BACKGROUND: Cadavers play an irreplaceable role in anatomy education, offering unique opportunities for hands-on learning and the internalization of e...
Osteosarcoma typically arises during adolescence, posing a significant challenge. Despite comprehensive treatment strategies encompassing surgery, rad...
BACKGROUND: Cardiac allograft rejection (CAR) remains the leading cause of early graft failure after heart transplantation (HT). Current diagnostics, ...
Immunotherapy has transformed cancer treatment but remains ineffective in many solid tumors, largely due to the immunosuppressive tumor microenvironme...
Chinese herbal medicine recommendations are a core part of personalized traditional Chinese medicine (TCM) diagnosis and treatment. However, the compl...
Strong non-invasive tests (NITs) are needed to predict decompensation in patients with compensated advanced chronic liver disease (cACLD) and improve ...
The application of artificial intelligence in computational pathology depends on both robust algorithms and high-quality, clinically reliable data. Pr...
BACKGROUND: Large language models (LLMs) are increasingly used for clinical information retrieval and decision support, yet comparative performance on...
Wide-bandgap (WBG) lead halide perovskite materials are indispensable top-cell materials for tandem solar cells (TSCs), whose high power-conversion po...
The structural diversity and complex transport behavior of per- and polyfluoroalkyl substances (PFAS) complicate a universal characterization of their...
The present manuscript provides a comprehensive overview of neural stem cell (NSC)-derived extracellular vesicles (NSC-EVs( as a cell-free approach to...
Accurate identification of human leukocyte antigen (HLA) class I-presented epitopes is essential for developing personalized vaccines and immunotherap...
Type 1 diabetes (T1D) has a large genetic component, and expanded genetic studies of T1D can enhance biological and therapeutic discovery and improve ...
Long-term transplant success is limited by allograft rejection, a complex process traditionally studied on an organ-specific basis. To establish a uni...
Sickle cell disease (SCD) is a single-gene illness which causes painful vaso-occlusion, debilitating organ damage, and early mortality. Its clinical c...
Fecal microbiota transplantation (FMT) has emerged as a promising therapy for gastrointestinal diseases, yet its clinical efficacy remains individuall...
Calcineurin represents a prominent target for immunosuppressive drugs, where conventional macrocyclic inhibitors utilize an immunophilin-dependent mec...