Latest AI and machine learning research in transplantation for healthcare professionals.
Sepsis remains a leading cause of mortality in intensive care units worldwide, a challenge exacerbated by pathophysiological and clinical heterogeneity that limits the effectiveness of uniform management strategies, motivating the development of phenotype-guided approaches to diagnosis and treatment. Artificial intelligence (AI)-assisted phenotyping can stratify patients with sepsis into distinct ...
Passive membrane permeability of N-methylated macrocyclic peptides remains poorly understood because high-energy conformational intermediates are rarely sampled by conventional methods. Using the deep learning-driven rare-event sampling framework ES-CRUMPLE, we show that cyclosporine A accesses transient amphiphilic states via a localized conformational hinge at Ala7/D-Ala8, revealing a kinetic de...
BACKGROUND: Cardiac transthyretin amyloidosis (ATTR-CA) is frequently underdiagnosed and commonly presents as heart failure with preserved ejection fr...
Tactile perception is essential for human interaction with the external world and holds significant potential in robotics, wearable devices, prostheti...
INTRODUCTION: Delayed graft function (DGF) is a frequent early complication after kidney transplantation. We systematically reviewed artificial intell...
CLDN18.2 is a promising tumor-specific antigen; however, the development of therapeutic antibodies against it is challenged by the need for simultaneo...
BACKGROUND: Sunitinib resistance remains a major clinical challenge in renal cell carcinoma, and the underlying molecular mechanisms are incompletely ...
RATIONALE AND OBJECTIVES: To evaluate the application value of intelligent organ recognition technology combined with the artificial intelligence iter...
Accurate determination of human epidermal growth factor receptor 2 (HER2) gene amplification is a cornerstone of precision oncology in breast cancer a...
The FDA Modernization Act has accelerated the transition from animal-based testing toward human-relevant new approach methodologies in drug developmen...
BACKGROUND: Suspected invasive pulmonary aspergillosis (IPA) is increasingly treated in intensive care, including in patients without classical immuno...
Endoscopic diagnostics and treatment of early esophageal neoplasia have achieved considerable progress in recent years. For Barrett's esophagus-associ...
The Cardiovascular-Kidney-Metabolic (CKM) syndrome reframes cardiovascular, kidney, and metabolic disease as an integrated continuum, yet its manageme...
Diabetic encephalopathy (DE) is a serious complication of diabetes mellitus characterized by progressive cognitive dysfunction; but its underlying mec...
Proton exchange membrane water electrolysis (PEMWE) has emerged as a core technology for green hydrogen production owing to its fast dynamic response ...
Brain cancer is one of the most challenging malignancies and a major contributor to worldwide morbidity and mortality. Glioblastoma, the most aggressi...
Rechargeable metal-sulfur batteries (MSBs) are promising next‑generation energy storage systems because of their high theoretical energy density and t...
Microalgae offer a promising platform for carotenoid manufacturing due to their productivity, tunable selectivity, and compatibility with large-scale ...
BACKGROUND: Chronic kidney disease (CKD) is projected to become one of the leading causes of premature mortality worldwide by 2050. Simultaneously, ad...
Red blood cell (RBC) transfusion is a core clinical intervention. However, hypothermic storage induces progressive biochemical, structural, and functi...