Transplantation

Latest AI and machine learning research in transplantation for healthcare professionals.

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Recent Advances in Organic Donor-Acceptor Two-Photon Absorption Materials: Mechanisms, Molecular Design, and Applications.

Organic materials have been widely recognized as highly promising candidates for two-photon absorption (TPA) applications owing to their strong optical absorption, readily tunable molecular structures, and excellent processability. By introducing electron donors (D) and acceptors (A) either within molecules or through intermolecular interactions, D-A-type organic TPA materials have been successful...

Jul 5 2026 42402814

Vascular reprogramming in cancer: engineering the tumor microenvironment.

Tumor vasculature has traditionally been viewed as structurally and functionally abnormal and, therefore, is primarily targeted for inhibition. However, emerging evidence from vascular biology, regenerative medicine, and bioengineering challenges this paradigm, demonstrating that blood vessels actively instruct and shape the tumor microenvironment. Here, we propose that tumor vasculature functions...

Jul 5 2026 42402079
Organoid-AI platforms need integrated governance in drug discovery.

Organoid-AI platforms are becoming decision systems in drug discovery, not just combined tools. They shape compound prioritisation, toxicity assessmen...

Jul 4 2026 42401253
Deep Learning-Based Standard Section Recognition and Multi-Organ Segmentation in Upper Abdominal Ultrasound.

OBJECTIVE: To develop and evaluate deep learning models for upper abdominal ultrasound standard section recognition and downstream multi-organ segment...

Jul 4 2026 42399171
Tissue identity is the dominant determinant of cross-species transferability of a porcine developmental programme.

BACKGROUND: Reproducibility and cross-species translation using the domestic pig (Sus scrofa) are limited by the lack of a standardised molecular fram...

Jul 4 2026 42399791
TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review).

The poor prognosis of high‑grade gliomas, such as glioblastoma, is largely driven by a notably immunosuppressive tumor microenvironment (TME), wherein...

Jul 3 2026 42396649
A dynamic machine learning model for predicting organ transplant success to optimize donor organ utilization and reduce costs.

BACKGROUND: Organ recovery for transplantation costs approximately $40,000 per donor, yet nearly 20% of recovered kidneys ultimately go unused. Static...

Jul 3 2026 42394433
QSAR in the Browser: An Interactive Cheminformatics Web Application.

Cheminformatic analysis has been an active field for almost half a century, with considerable innovation accelerating drug discovery. However, the req...

Jul 3 2026 42397292
Exploring Informal Caregivers' Perception of the Olera Digital Caregiving Assistance Platform for Dementia Care: Mixed Methods Evaluation Study.

BACKGROUND: Informal caregivers of people living with dementia often experience high rates of caregiver burnout while providing care. Although there a...

Jul 3 2026 42398038
Multi-omics and metabolic flux modeling reveal that macrophage CYP27A1-derived 26-hydroxycholesterol drives immunosuppression and cancer malignancy.

Emerging evidence indicates that aberrant cholesterol metabolism in macrophages plays a role in tumorigenesis, however, how specific metabolites relea...

Jul 3 2026 42399552
Beyond native sequence recovery: Improved modeling of the sequence-energy landscape of protein structures.

Computational protein design using machine learning models has advanced rapidly since the introduction of AlphaFold2. There is now a suite of tools th...

Jul 2 2026 42391398
Leveraging multimodal cancer immunotherapy to amplify the efficacy of oncolytic viruses.

Oncolytic viruses (OVs) represent a versatile platform for cancer immunotherapy, capable of selectively infecting and lysing tumor cells while trigger...

Jul 2 2026 42393779
An EEG-based hybrid machine learning approach for CT scan triage in mild traumatic brain injury.

Mild traumatic brain injury (mTBI) frequently prompts computed tomography (CT) imaging in emergency departments, despite a high proportion of negative...

Jul 2 2026 42393204
Dual-mode analysis of ischemic stroke based on urine SERS spectra and carotid B-ultrasound.

Achieving noninvasive high-frequency monitoring of ischemic stroke (IS) remains a major clinical challenge for timely intervention and precise seconda...

Jul 1 2026 42384817
Integrative multi-omics and machine learning reveal PLAUR as a Pan-Cancer prognostic biomarker and potential therapeutic target.

Tumor heterogeneity remains a major barrier to effective cancer therapy, driving the need for novel biomarkers and targeted strategies. A bibliometric...

Jul 1 2026 42391812
Biobanking for intelligent medicine: assessment and evaluation with the SHARE principle.

BACKGROUND: Biobanks are essential for intelligent medicine but face fragmentation and heterogeneity. No standardized framework exists for assessing b...

Jul 1 2026 42043949
Improving mortality prediction in critically ill cancer patients with a multidimensional machine learning model.

BACKGROUND: Prognostic assessment in critically ill cancer patients is challenging due to the suboptimal performance of traditional severity scores. W...

Jul 1 2026 42384111
Real-World Analysis of Organ Transplantation-Specific Agent Based on Large Language Model in Post-Transplant Self-Management During Off-Hours: A Mixed-Methods Study.

OBJECTIVE: A significant gap exists in medical support for organ transplant patients during out-of-hours (OOH). General large language models (LLMs), ...

Jul 1 2026 42384291
A Self-Powered Sensing Platform Based on the Janus Heterostructure for Machine Learning-Assisted Dual-Mode Detection of 17β-Estradiol.

Interfacial energy level mismatch and inefficient charge extraction at bioelectrochemical interfaces have remained major bottlenecks for enzymatic bio...

Jul 1 2026 42384906
A salivary protein panel for detecting malignant transformation of oral leukoplakia.

Oral leukoplakia (OLK) is the most common oral potentially malignant disorder and carries a lifetime risk of transformation to oral squamous cell carc...

Jul 1 2026 42385552
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